Inhibition of HIV-1 replication by balsamin, a ribosome inactivating protein of Momordica balsamina. [PDF]
PLoS ONE, 2013 Ribosome-inactivating proteins (RIPs) are endowed with several medicinal properties, including antiviral activity. We demonstrate here that the recently identified type I RIP from Momordica balsamina also possesses antiviral activity, as determined by ...
Inderdeep Kaur +5 more
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A Sixty-Year Research and Development of Trichosanthin, a Ribosome-Inactivating Protein [PDF]
Toxins, 2022 Tian Hua Fen, a herbal powder extract that contains trichosanthin (TCS), was used as an abortifacient in traditional Chinese medicine. In 1972, TCS was purified to alleviate the side effects.
Jia-Qi Lu, Kam-Bo Wong, Pang-Chui Shaw
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Recombinant anti-HIV MAP30, a ribosome inactivating protein: against plant virus and bacteriophage [PDF]
Scientific Reports, 2023 The ribosome inactivating proteins (RIPs) efficiently decrease the microbial infections in plants. Momordica charantia MAP30 is a type I RIP that has not been investigated against plant viruses or bacteriophages.
Nafiseh Amirzadeh +3 more
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Structure and Activity of a Cytosolic Ribosome-Inactivating Protein from Rice [PDF]
Toxins, 2019 Ribosome-inactivating proteins (RIPs) are cytotoxic enzymes that inhibit protein translation by depurinating ribosomal RNA. Although most plant RIPs are synthesized with leader sequences that sequester them away from the host ribosomes, several RIPs from
Jeroen De Zaeytijd +3 more
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Pokeweed Antiviral Protein, a Ribosome Inactivating Protein: Activity, Inhibition and Prospects [PDF]
Toxins, 2015 Viruses employ an array of elaborate strategies to overcome plant defense mechanisms and must adapt to the requirements of the host translational systems. Pokeweed antiviral protein (PAP) from Phytolacca americana is a ribosome inactivating protein (RIP)
Artem V. Domashevskiy, Dixie J. Goss
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In-silico analysis of ribosome inactivating protein (RIP) of the Cucurbitaceae family [PDF]
AMB ExpressRibosome-inactivating proteins (RIPs) are highly active N-glycosidases that depurinate both bacterial and eukaryotic rRNAs, halting protein synthesis during translation.
Quratulain Maqsood +5 more
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Crystal Structure of Ribosome-Inactivating Protein Ricin A Chain in Complex with the C-Terminal Peptide of the Ribosomal Stalk Protein P2 [PDF]
Toxins, 2016 Ricin is a type 2 ribosome-inactivating protein (RIP), containing a catalytic A chain and a lectin-like B chain. It inhibits protein synthesis by depurinating the N-glycosidic bond at α-sarcin/ricin loop (SRL) of the 28S rRNA, which thereby prevents the ...
Wei-Wei Shi +5 more
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The Recombinant Maize Ribosome-Inactivating Protein Transiently Reduces Viral Load in SHIV89.6 Infected Chinese Rhesus Macaques [PDF]
Toxins, 2015 Ribosome inactivating proteins (RIPs) inhibit protein synthesis by depurinating the large ribosomal RNA and some are found to possess anti-human immunodeficiency virus (HIV) activity. Maize ribosome inactivating protein (RIP) has an internal inactivation
Rui-Rui Wang +13 more
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Metazoan Ribosome Inactivating Protein encoding genes acquired by Horizontal Gene Transfer [PDF]
Scientific Reports, 2017 Ribosome inactivating proteins (RIPs) are RNA N-glycosidases that depurinate a specific adenine residue in the conserved sarcin/ricin loop of 28S rRNA.
Walter J. Lapadula +4 more
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Cytotoxicity Effect of Quinoin, Type 1 Ribosome-Inactivating Protein from Quinoa Seeds, on Glioblastoma Cells [PDF]
Toxins, 2021 Ribosome-inactivating proteins (RIPs) are found in several edible plants and are well characterized. Many studies highlight their use in cancer therapy, alone or as immunoconjugates, linked to monoclonal antibodies directed against target cancer cells ...
Rossella Rotondo +7 more
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