Results 51 to 60 of about 25,572 (194)
Improvement of the Pharmacological Properties of Maize RIP by Cysteine-Specific PEGylation
Toxins, 2016 To improve the pharmacological properties of maize ribosome-inactivating protein (maize RIP) for targeting HIV-infected cells, the previously engineered TAT-fused active form of maize RIP (MOD) was further engineered for cysteine-directed PEGylation.
Ka-Yee Au +4 more
doaj +1 more source
Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1 [PDF]
, 2012 We previously developed an antibody-avidin fusion protein (ch128.1Av) that targets the human transferrin receptor 1 (TfR1) and exhibits direct cytotoxicity against malignant B cells in an iron-dependent manner. ch128.1Av is also a delivery system and its
Casero, David +9 more
core +2 more sources
Avoiding chromosome pathology when replication forks collide [PDF]
, 2013 This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2013 Macmillan Publishers Limited.Chromosome duplication normally initiates through the assembly of replication fork complexes at defined ...
Lloyd, RG +3 more
core +1 more source
Ribosome inactivation by Escherichia coli GTPase RsgA inhibits T4 phage
Frontiers in Microbiology, 2023 IntroductionBacteria must combat phages, and myriad bacterial anti-phage systems have been discovered that reduce host metabolism, for example, by depleting energetic compounds like ATP and NAD+. Hence, these systems indirectly inhibit protein production.
Laura Fernández-García +3 more
doaj +1 more source
, 2008 We studied the in vitro and in planta antiviral activity of the PhRIP I, a type 1 Ribosome-Inactivating Protein originally purified from leaves of the Phytolacca heterotepala.
ANTIMO DI MARO +6 more
core +1 more source
Involvement of loops 2 and 3 of alpha-sarcin on its ribotoxic activity [PDF]
, 2015 Ribotoxins are a family of fungal ribosome-inactivating proteins displaying highly specific ribonucleolytic activity against the sarcin/ricin loop (SRL) of the larger rRNA, with a-sarcin as its best-characterized member.
Castaño Rodríguez, Carlos +7 more
core +1 more source
Lectin domains at the frontiers of plant defense [PDF]
, 2014 Plants are under constant attack from pathogens and herbivorous insects. To protect and defend themselves, plants evolved a multi-layered surveillance system, known as the innate immune system.
Lannoo, Nausicaä, Van Damme, Els
core +2 more sources
PlantsThe apoplast is often the first point of contact between plant cells and invading pathogens, serving as an important site for defense signaling. Pokeweed antiviral protein (PAP), a ribosome-inactivating protein from Phytolacca americana (pokeweed), is ...
Annabelle Audet +2 more
doaj +1 more source
A Monoclonal–Monoclonal Antibody Based Capture ELISA for Abrin
Toxins, 2017 Abrin, one of the most highly potent toxins in the world, is derived from the plant, Abrus precatorius. Because of its high toxicity, it poses potential bioterror risks.
Christina C. Tam +5 more
doaj +1 more source
Characterization of a new toxin from the entomopathogenic fungus Metarhizium anisopliae: the ribotoxin anisoplin [PDF]
, 2016 Metarhizium anisopliae is an entomopathogenic fungus relevant in biotechnology with applications like malaria vector control. Studies of its virulence factors are therefore of great interest.
Budia, Flor +5 more
core +2 more sources