Results 41 to 50 of about 3,398,083 (202)

Ribosome-inactivating lectins with polynucleotide:adenosine glycosidase activity [PDF]

, 1997
Lectins from Aegopodium podagraria (APA), Bryonin dioica (BDA), Galanthus nivalis (GNA), Iris hybrid (IRA) and Sambucus nigra (SNAl), and a new lectin-related protein from Sambucus nigra (SNLRP) were studied to ascertain whether they had the properties ...
Valbonesi P., Polito L., Barbieri L., Buonamici L., Bolognesi A., Van Damme E. J. M., Stirpe F., Battelli M. G., Peumans W. J.   +8 more
core   +2 more sources

Constitutive and inducible type 1 ribosome‐inactivating proteins (RIPs) in elderberry (Sambucus nigra L.)

FEBS Letters, 1998
Two novel highly basic type 1 (single chain) ribosome‐inactivating proteins (RIPs) with N‐glycosidase activity have been found in elderberries (the fruits of Sambucus nigra L.). Mass spectrometry of these RIPs, which we named nigritins f1 and f2, gave M r values of 24 095 and 23 565, respectively.
de Benito, Fernando M, Iglesias, Rosario, Ferreras, José Miguel, Citores, Lucı́a, Camafeita, Emilio, Méndez, Enrique, Girbés, Tomás   +6 more
openaire   +2 more sources

Supervised Protein Structure Classification Using Topological Persistence With DeltaFold

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Recent advances in protein structure prediction have considerably increased the number of available structures, underscoring the need for scalable and accurate methods to compare and classify this huge amount of data. Current approaches based on sequence alignment or structural superposition often lack sensitivity and/or are computationally ...
Joseph Nardin‐Gennequin, Gabriela Ciuperca, Céline Brochier‐Armanet, Philippe Malbos   +3 more
wiley   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, Volume 13, Issue 53, 24 September 2026.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Ribosome-inactivating Proteins from Phytolaccaceae

, 2014
The plant family Phytolaccaceae is a rich source of ribosome-inactivating proteins (RIPs), including the first characterized non-toxic type 1 RIP, pokeweed antiviral protein from the plant Phytolacca americana. The antiviral property is important because
DI MARO, Antimo, Angela Chambery, Parente A, Rosita Russo, Augusto Parente, Severino V., Valeria Severino, Antimo Di Maro, CHAMBERY, Angela, Russo R   +9 more
core   +1 more source

Pokeweed Antiviral Protein: Its Cytotoxicity Mechanism and Applications in Plant Disease Resistance

Toxins, 2015
Pokeweed antiviral protein (PAP) is a 29 kDa type I ribosome inactivating protein (RIP) found in pokeweed plants. Pokeweed produces different forms of PAP. This review focuses on the spring form of PAP isolated from Phytolacca americana leaves.
Rong Di, Nilgun E. Tumer
doaj   +1 more source

Targeting eIF5A combats breast cancer progression by ClpP‐dependent mitochondrial oxidative stress

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
This study identified the eIF5A‐ClpP axis as a key driver of breast cancer progression. Targeting eIF5A suppresses tumor growth by inducing ClpP‐dependent mitochondrial oxidative stress, revealing a novel therapeutic vulnerability. Abstract Breast cancer (BC) poses a persistent global health challenge, necessitating new therapeutic targets.
Jinmei Zhu, Baoyuan Tang, Bei Xie, Haohua Deng, Haitang Yang, Lei Ma, Ziqing Zhang, Yicheng Ma, Xingyuan Ma, Shuaiyang Wang, Jing Li, Lei Zhao, Wengui Shi, Linjing Li   +13 more
wiley   +1 more source

Structural and Functional Investigation and Pharmacological Mechanism of Trichosanthin, a Type 1 Ribosome-Inactivating Protein

Toxins, 2018
Trichosanthin (TCS) is an RNA N-glycosidase that depurinates adenine-4324 in the conserved α-sarcin/ricin loop (α-SRL) of rat 28 S ribosomal RNA (rRNA).
Wei-Wei Shi, Kam-Bo Wong, Pang-Chui Shaw
doaj   +1 more source

Pharmacological investigation of ribosome inactivating protein (RIP) – like protein extracted from Annona squamosa L. seeds

Journal of King Saud University - Science, 2020
Abstract Ribosome Inactivating Proteins (RIPs), are plant proteins with N Glycosidase activity. Annona squamosa is traditionally used in medicine but RIP presence is less explored. The present study aimed to isolate and structurally analyse RIP- like protein from the seeds of Annona squamosa (ARIP) and investigate its in vitro pharmacological ...
Sobiya Raj Dhanraj, J. Jannet Vennila, Muthu Dhanraj   +2 more
openaire   +1 more source

Squash silverleaf disorder and whitefly (Bemisia tabaci MEAM1) infestation: Implications for plant disease management in a changing climate

Annals of Applied Biology, Volume 189, Issue 2, September 2026.
Squash Silverleaf Disorder (SLD) is growing in its economic impact due to the invasive behaviour of the silverleaf whitefly (Bemisia tabaci MEAM1). In this review we summarize what is currently known about the whitefly‐squash interaction, how both the disease and the whitefly are being affected by climate change, and discuss current and novel ...
Nihal Oztolan‐Erol, Yusuf Sen, Melike Cokol‐Cakmak, Guler Demirbas‐Uzel, Stuart J. Lucas   +4 more
wiley   +1 more source