Results 51 to 60 of about 3,398,083 (202)
Cell Targeted Ribosome Inactivating Proteins Derived from Protein Combinatorial Libraries [PDF]
, 2008 Combinatorial protein libraries based on a protein template offer a vast potential for deriving protein variants harboring new receptor specificity while retaining other tem-plate functions to serve as library search-engines, cell-routing sequences and ...
Perampalam, Subodini
core +2 more sources
Toxins, 2017 Plant ribosome-inactivating protein (RIP) toxins are EC3.2.2.22 N-glycosidases, found among most plant species encoded as small gene families, distributed in several tissues being endowed with defensive functions against fungal or viral infections.
Maria Serena Fabbrini +3 more
doaj +1 more source
Toxins, 2023 Cetuximab is a monoclonal antibody blocking the epidermal growth factor receptor (EGFR) in metastatic colorectal cancer (mCRC). However, cetuximab treatment has no clinical benefits in patients affected by mCRC with KRAS mutation or in the presence of ...
Nicola Landi +7 more
doaj +1 more source
Molecular characterization and systemic induction of single-chain ribosome-inactivating proteins (RIPs) in sugar beet (Beta vulgaris) leaves [PDF]
Journal of Experimental Botany, 2005 Sugar beet (Beta vulgaris L.) leaves contain virus-inducible type 1 (single chain) ribosome-inactivating proteins that have been named beetins. The structural and functional characterization, the cellular location, and the potential role of beetins as antiviral agents are reported here.
Iglesias Álvarez, María del Rosario +8 more
openaire +2 more sources
Ribosome-inactivating proteins [PDF]
, 2013 Ribosome-inactivating proteins (RIPs) were first isolated over a century ago and have been shown to be catalytic toxins that irreversibly inactivate protein synthesis.
Dodd, J.E. +2 more
core +1 more source
, 2010 Ribosome-inactivating proteins (RIP) inhibit protein synthesis in eukaryotic cells by catalytically damaging ribosomes. They are most abundant in a few plant families which include the Euphorbiaceae family.
MARICEL, CORPUZ
core +1 more source
Neutralization and binding activity of a human single-chain antibody to ricin toxin
Food and Agricultural Immunology, 2020 Ricin toxin (RT), extracted from castor bean, is a type II ribosome-inactivating protein (RIP). As a biothreat agent, there is no effective antidote for RT to date, but recent advances in antibody research may have meet this need.
Haotian Yu +8 more
doaj +1 more source
Oligopeptides/DNA Coacervate Droplets as Macromolecular Delivery Microcarriers
Advanced Science, Volume 13, Issue 44, 7 August 2026.Oligopeptide–DNA coacervates formed via liquid–liquid phase separation serve as programmable carriers for macromolecular cargos, entering cells through lipid raft–associated pathways and subsequently undergoing enzyme triggered intracellular disassembly driven by DNA degradation processes, thereby enabling efficient, controlled, and spatially defined ...
Linyi Zhang +5 more
wiley +1 more source
Designing a Humanized Immunotoxin Based on Gelonin Against HER2+ Breast Cancer: An In-Silico Study [PDF]
Brazilian Journal of Pharmaceutical SciencesRecombinant immunotoxins (RITs) are considered tumor-specific therapeutics because their variable antibody fragment can specifically bind to target cells, and their engineered toxin fragment specifically kills cancerous cells upon internalization.
Mahsa Daneshmand +2 more
doaj +1 more source
Identification of the tRNAs which up‐regulate agrostin, barley RIP and PAP‐S, three ribosome‐inactivating proteins of plant origin [PDF]
FEBS Letters, 1998 Ribosome‐inactivating proteins (RIP) are RNA‐N‐glycosidases widely diffused in plants which depurinate ribosomal RNA at a specific universally conserved position, A4324 in rat ribosomes. A small group of RIPs (cofactor‐dependent RIPs) require ATP and tRNA to reach maximal activity on isolated ribosomes.
Brigotti, Maurizio +7 more
openaire +3 more sources