Results 61 to 70 of about 1,934 (175)
Toxins, 2023 Cetuximab is a monoclonal antibody blocking the epidermal growth factor receptor (EGFR) in metastatic colorectal cancer (mCRC). However, cetuximab treatment has no clinical benefits in patients affected by mCRC with KRAS mutation or in the presence of ...
Nicola Landi +7 more
doaj +1 more source
Identification of the tRNAs which up‐regulate agrostin, barley RIP and PAP‐S, three ribosome‐inactivating proteins of plant origin [PDF]
FEBS Letters, 1998 Ribosome‐inactivating proteins (RIP) are RNA‐N‐glycosidases widely diffused in plants which depurinate ribosomal RNA at a specific universally conserved position, A4324 in rat ribosomes. A small group of RIPs (cofactor‐dependent RIPs) require ATP and tRNA to reach maximal activity on isolated ribosomes.
Brigotti, Maurizio +7 more
openaire +2 more sources
Programmable RNA N6,2´‐O‐Dimethyladenosine Editing
Advanced Science, Volume 13, Issue 29, 22 May 2026.ABSTRACT N6,2’‐O‐dimethyladenosine (m6Am) is a prevalent RNA modification located at the first transcribed nucleotide adjacent to the 5′ cap of mRNAs, where it has been implicated in gene regulation. However, the lack of methods for precise, transcript‐specific manipulation of m6Am has limited its functional dissection.
Yang Li +9 more
wiley +1 more source
Neutralization and binding activity of a human single-chain antibody to ricin toxin
Food and Agricultural Immunology, 2020 Ricin toxin (RT), extracted from castor bean, is a type II ribosome-inactivating protein (RIP). As a biothreat agent, there is no effective antidote for RT to date, but recent advances in antibody research may have meet this need.
Haotian Yu +8 more
doaj +1 more source
Lectinas vegetales: utilización en histoquímica y terapia antitumoral [PDF]
, 2016 Numerosas plantas expresan en su composición una o más lectinas o bien proteínas con un dominio lectina, permitiendo a éstas seleccionar y unirse a determinadas estructuras.
Velasco Martín, Felipe
core
Molecular Ecology, Volume 35, Issue 7, April 2026.ABSTRACT Many bacterial taxa evolved facultative symbiotic associations with insects and spread through host populations by horizontal and maternal transmission. Co‐infection at the individual host level may facilitate or constrain the spread of facultative symbionts.
Diego Castillo Franco +6 more
wiley +1 more source
Designing a Humanized Immunotoxin Based on Gelonin Against HER2+ Breast Cancer: An In-Silico Study [PDF]
Brazilian Journal of Pharmaceutical SciencesRecombinant immunotoxins (RITs) are considered tumor-specific therapeutics because their variable antibody fragment can specifically bind to target cells, and their engineered toxin fragment specifically kills cancerous cells upon internalization.
Mahsa Daneshmand +2 more
doaj +1 more source
From Immunotoxins to Suicide Toxin Delivery Approaches: Is There a Clinical Opportunity?
Toxins, 2022 Suicide gene therapy is a relatively novel form of cancer therapy in which a gene coding for enzymes or protein toxins is delivered through targeting systems such as vesicles, nanoparticles, peptide or lipidic co-adjuvants.
Matteo Ardini +3 more
doaj +1 more source
TaRIP2 Positively Regulates Wheat Pollen Wall Formation Through MYB80‐Controlled Lipid Metabolism
Plant Biotechnology Journal, Volume 24, Issue 4, Page 2595-2606, April 2026.ABSTRACT Male‐sterile genes and mutants are critical for hybrid seed production in monocotyledonous crops. Lipids are essential structural components of male reproductive organs, such as the anther and pollen. Here, we show that the pollen‐preferential gene TaRIP2 is essential for wheat anther development and pollen formation. RT‐qPCR analysis revealed
Ran Han +14 more
wiley +1 more source
ToxinsMalanin is a new type II ribosome-inactivating protein (RIP) purified from Malania oleifera, a rare, endangered tree is only found in the southwest of Guangxi Province and the southeast of Yunnan Province, China.
Yan Yuan, Shuxiao Wu, Philip J. R. Day
doaj +1 more source