Results 61 to 70 of about 3,398,083 (202)

Tumour‐Derived Extracellular Vesicles Containing dsRNA Induce Degradation of Ribosomal Protein mRNA in Platelets

Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.
ABSTRACT Extracellular vesicles (EVs) mediate intercellular communication within the tumour microenvironment by carrying cargoes from paracrine parent cells. EVs have attracted great research interest for their ability to carry nucleic acids into recipient cells and modulate cellular functions.
Gaoge Sun, Yuhuan Tao, Zihan Liu, Kaixiang Zhang, Shuai Zuo, Shanwen Chen, Shufang Ning, Tianyi Zhang, Pengyuan Wang, Ying Zhang, Zhi John Lu, Hang Hubert Yin   +11 more
wiley   +1 more source

Ribosomal RNA N-glycosylase Activity Assay of Ribosome-inactivating Proteins

Bio-Protocol, 2017
Ribosome-inactivating proteins (RIPs) are enzymes that irreversibly inactivate ribosomes as a consequence of their N-glycosylase (EC 3.2.2.22) activity. The enzyme cleaves the N-glycosidic bond between the adenine No.
José Ferreras, Lucía Citores, José Ferreras   +2 more
doaj   +1 more source

From Immunotoxins to Suicide Toxin Delivery Approaches: Is There a Clinical Opportunity?

Toxins, 2022
Suicide gene therapy is a relatively novel form of cancer therapy in which a gene coding for enzymes or protein toxins is delivered through targeting systems such as vesicles, nanoparticles, peptide or lipidic co-adjuvants.
Matteo Ardini, Riccardo Vago, Maria Serena Fabbrini, Rodolfo Ippoliti   +3 more
doaj   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, Volume 13, Issue 39, 13 July 2026.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Pemurnian Ribosome Inactivating Protein (RIP) Bui Annona squamosa L. Dengan KOLOM CM-SEPHAROSE CL-6B

, 2004
INTISARI Sudjadi. 2004. Pemurnian Ribosome Inactivating Protein (RIP) Biji Annona squamosa L. Dengan Kolom CM-Sepharose CL-6B. Biologi 3 (3): 181 -190. Hasil penelitian terdahulu menunjukkan bahwa ekstrak gubal biji Annona squamosa L. mempunyai aktivitas
Sudjadi
core   +2 more sources

High‐Throughput Isolation of Nanomouse‐Derived VHH Domains: A Practical Guide from Immunization to Nanobody Expression

Current Protocols, Volume 6, Issue 7, July 2026.
Abstract Nanobodies are small but specific heavy chain–only antibody fragments. Their small size, relative stability, and ability to access difficult to reach deep‐tissue antigens makes them valuable research, diagnostic, and therapeutic tools. Nanobodies are derived from the variable heavy (VH) domain of heavy chain–only antibodies that are unique to ...
Tessa J. Casselman, Asa W. Huffaker, Kristie C. Mitchell, Jamie E. Schnarrs, Sylvia Ni, Mary E. Skinner, Matthias C. Truttmann   +6 more
wiley   +1 more source

m6A‐modified DRAM1 recognized by YTHDF1 regulates autophagy during dexamethasone‐induced osteogenic inhibition

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
DRAM1 plays a critical role in the modulation of autophagy. The m6A methylation level of DRAM1 mRNA is suppressed by dexamethasone. Dexamethasone impairs autophagy‐associated osteogenic differentiation by inhibiting YTHDF1‐mediated translation of m6A‐modified DRAM1.
Ze‐Yu Lu, Peng‐Bo Chen, Qing‐Yin Xu, Muradil Mardan, Yue‐Hua Yang, Tao Liu, Wen‐Ning Xu, Huo‐Liang Zheng, Hao Cai, Hui Deng, Xing‐Xu Huang, Bo Li, Sheng‐Dan Jiang, Lei‐Sheng Jiang, Xin‐Feng Zheng   +14 more
wiley   +1 more source

CYTOTOXICITY AGAINST TUMOR CELL LINES OF A RIBOSOME-INACTIVATING PROTEIN (RIP)-LIKE PROTEIN ISOLATED FROM LEAVES OF MIRABILIS JALAPA L. [PDF]

Malaysian Journal of Pharmaceutical Sciences, 2006
The 30 kD protein fraction with properties like ribosome-inactivating protein (RIP) was isolated from the leaves of Mirabilis jalapa L. and named MJ-30. This study investigated the cytotoxic effect of MJ-30 on normal and malignant cells.
ZULLIES IKAWATI, SUDJADI, SISMINDARI
doaj  

Cellular signaling within aged skeletal muscle reveals a dysregulated stress‐induced remodeling response following volumetric muscle loss in female mice

Physiological Reports, Volume 14, Issue 14, July 2026.
Muscle from aged mice exhibits dysregulated inflammatory and kinase‐signaling responses and altered functional dynamics following volumetric muscle loss, despite structural pathology similar to that in young mice. Abstract Severe muscle trauma disrupts endogenous repair mechanisms and produces chronic functional deficits that are poorly defined in ...
Krista M. Habing, Tyler J. Sagendorf, Cynthia A. Alcazar‐Daleo, James A. Sanford, Damon Leach, Joshua C. Vanderpool, Chelsea M. Hutchinson‐Bunch, Marina Gritsenko, Gina M. Many, Karina H. Nakayama   +9 more
wiley   +1 more source

Uji Aktivitas Ribosome Inactivating Protein (Rip) Pada Tiga -Spesies Familia Cucurbitaceae Trichosanthes Anguina L., Cucurbita Moschata Duch. DAN Citrullus Vulgaris Schrad [PDF]

, 2002
ANBTRACT Ribosome Inactivating Protein (RIP) is a protein enzime which is produced by plants and act in ribosome there by inhibiting protein synthesis. This effect is caused by the RNA Nglycosidase activity that cleaves the glycosidic adenin4324 chain on
Juziyat Rozanati, Hari Hartiko, Rarastoeti Pratiwi
core   +2 more sources