Results 71 to 80 of about 3,398,083 (202)

Ribosome-Inactivating Proteins: From Plant Defense to Tumor Attack

open access: yesToxins, 2010
Ribosome-inactivating proteins (RIPs) are EC3.2.32.22 N-glycosidases that recognize a universally conserved stem-loop structure in 23S/25S/28S rRNA, depurinating a single adenine (A4324 in rat) and irreversibly blocking protein translation, leading ...
Maria Serena Fabbrini   +3 more
doaj   +1 more source

Unexpected Toxicity of Green Tea Polyphenols in Combination with the Sambucus RIL Ebulin

open access: yesToxins, 2020
The safety of concentrated food complements intake is a major health concern. It has been well established that green tea polyphenols (GTPs) consumption promotes healthy effects.
M. Ángeles Rojo   +6 more
doaj   +1 more source

Structural Basis for Nucleobase Activation by the Adenine DNA Glycosylase MutY

open access: yesChemBioChem, Volume 27, Issue 11, 15 June 2026.
DNA glycosylase MutY engages its adenine nucleobase substrate in a syn orientation with a catalytic Glu. X‐ray crystal structures of MutY with Glu replaced suggest that a disengaged “on hold” state with anti nucleobase orientation may explain how MutY avoids catastrophic activity at inappropriate adenines.
L. Peyton Russelburg   +4 more
wiley   +1 more source

Studies on ribosome-inactivating proteins from momordica charantia. [PDF]

open access: yes, 1997
by Tse Man Fai.Thesis (M.Phil.)--Chinese University of Hong Kong, 1997.Includes bibliographical references (leaves 74-81).ACKNOWLEDGMENTS --- p.IABSTRACT --- p.IILIST OF ABBREVIATIONS --- p.IIITABLE OF CONTENTS --- p.1Chapter CHAPTER 1 ...

core  

Ribosome-inactivating protein-containing conjugates for therapeutic use

open access: yes, 2010
A number of plant proteins inhibit protein synthesis by irreversibly inactivating the 60S ribosomal subunit in a catalytical, that is, enzymatic, manner. For this property, they are called ribosome-inactivating proteins (RIPs).
COLOMBATTI, Marco   +2 more
core   +1 more source

Extensive Evolution of Cereal Ribosome-Inactivating Proteins Translates into Unique Structural Features, Activation Mechanisms, and Physiological Roles

open access: yesToxins, 2017
Ribosome-inactivating proteins (RIPs) are a class of cytotoxic enzymes that can depurinate rRNAs thereby inhibiting protein translation. Although these proteins have also been detected in bacteria, fungi, and even some insects, they are especially ...
Jeroen De Zaeytijd, Els J. M. Van Damme
doaj   +1 more source

Visualization of Endosomal Escape of Intracellularly Delivered Protein With Unexpected Photochemical Internalization of Trypan Blue

open access: yesAdvanced Science, Volume 13, Issue 32, 9 June 2026.
TB, a conventional cell viability dye, acts as both a fluorescence modulator (quenching GFP fluorescence upon protein binding and recovering it upon release) and a photosensitizer that triggers endosomal escape via photochemical internalization (PCI) under 590 nm light.
Zhongqi Yao   +4 more
wiley   +1 more source

DIANTHIN, a negative selection marker in tobacco, is non-toxic in transgenic rice and confers sheath blight resistance

open access: yesBiologia Plantarum, 2010
The DIANTHIN gene encoding a ribosome-inactivating protein (RIP) from Dianthus caryophyllus L. was tested for negative selection in tobacco and rice. Tobacco leaf discs and scutellum-derived callus of rice were transformed with Agrobacterium tumefaciens ...
J. M. Shah, K. Veluthambi
doaj   +1 more source

Cloning and Bacterial Expression of Karasurins, Ribosome-Inactivating Proteins (RIPs) from Trichosanthes Kirilowii var. Japonica

open access: yesPlant Biotechnology, 2001
A genomic clone encoding a karasurin precursor was isolated from root tubers of Trichosanthes kirilowii var. japonica. The sequence analysis indicates that karasurin-A and karasurin-C exhibiting abortifacient and ribosome-inhibiting activities are produced from a common karasurin precursor by proteolitically cleaving at a different site.
MIZUKAMI, Hajime   +4 more
openaire   +2 more sources

The pokeweed leaf mRNA transcriptome and its regulation by jasmonic acid.

open access: yesFrontiers in Plant Science, 2016
The American pokeweed plant, Phytolacca americana, is recognized for synthesizing pokeweed antiviral protein (PAP), a ribosome inactivating protein (RIP) that inhibits the replication of several plant and animal viruses.
Kira C.M. Neller   +2 more
doaj   +1 more source

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