Results 71 to 80 of about 1,934 (175)

Ribosomal RNA N-glycosylase Activity Assay of Ribosome-inactivating Proteins

Bio-Protocol, 2017
Ribosome-inactivating proteins (RIPs) are enzymes that irreversibly inactivate ribosomes as a consequence of their N-glycosylase (EC 3.2.2.22) activity. The enzyme cleaves the N-glycosidic bond between the adenine No.
José Ferreras, Lucía Citores, José Ferreras   +2 more
doaj   +1 more source

Efficacy of photochemical internalisation using disulfonated chlorin and porphyrin photosensitisers: An in vitro study in 2D and 3D prostate cancer models [PDF]

, 2017
This study shows the therapeutic outcome of Photochemical Internalisation (PCI) in prostate cancer in vitro surpasses that of Photodynamic Therapy (PDT) and could improve prostate PDT in the clinic, whilst avoiding chemotherapeutics side effects.
Hamoudi, RA, MacRobert, AJ, Martinez de Pinillos Bayona, A, Moore, CM, Pye, H, Woodhams, JH   +5 more
core   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

Membrane fusion mediated by ricin and viscumin [PDF]

, 1998
The ribosome inactivating plant proteins (RIPs) ricin and viscumin but not Ricinus communis agglutinin are able induce vesicle–vesicle fusion. A model is suggested in which the toxicity of the RIPs is partially determined by their fusogenicity.
Peter Pohl, Yura N Antonenko, Veronika Y Evtodienko, Elena E Pohl, Sapar M Saparov, Igor I Agapov, Alexander G Tonevitsky, Lord, Brinkmann, Sandvig, Beaumelle, Bilge, Sandvig, O'Hare, Citores, Saltvedt, Barbieri, Bendas, Köhler, Tonevitsky, Woodbury, Mueller, MacDonald, Utsumi, Chernomordik, Simon, Hoekstra, Yoshida, Yoshida, Simpson, Rapak, Bau, Okimoto, Hudson, Siegel, Tonevitsky, Agapov, Goldmacher, Gottstein, Raso   +39 more
core   +1 more source

Genome‐wide association study identifies consistent genomic loci for yield and nutritional quality in Ethiopian sorghum landraces

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Identifying genomic regions linked to yield and quality is crucial for sorghum (Sorghum bicolor L.) improvement, but limited studies on its genome and diversity hinder breeding efforts. This study aimed to identify phenotypic variance and common quantitative trait nucleotides (QTNs) associated with genomic regions linked with grain yield and ...
Chalachew Endalamaw, Temesgen M. Menamo, Firezer G. Kebede, Zeleke Wondimu, Hailekiros Tadesse Tekle, Kwame Shamuyarira, Angeline Jacoby, Maryke Tine Labuschagne   +7 more
wiley   +1 more source

Alteraciones histológicas causadas por la administración intraperitoneal de ebulina en ratones [PDF]

, 2017
La ebulina es una proteína inhibidora de ribosomas tipo 2 con actividad lectina (RIL) aislada del saúco enano. Los frutos del saúco se han consumido desde la antigüedad por sus atribuidos efectos medicinales.
Vicente Pardo, Andrea
core  

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, Volume 13, Issue 12, 27 February 2026.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Comparative Efficacy of Ribosome-Inactivating Protein-Containing Immunotoxins in 2D and 3D Models of Sarcoma

Toxins
Sarcomas are very complex and clinically challenging mesenchymal tumors. Although the standard therapeutic approach has improved the 5-year survival rate, many patients experience local relapses and/or distant metastases.
Giulia Calafato, Massimo Bortolotti, Letizia Polito, Andrea Bolognesi   +3 more
doaj   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, Volume 13, Issue 10, 18 February 2026.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

Structure of Ribosome-Inactivating Protein from Mirabilis jalapa and Its L12-Stalk-Dependent Inhibition of Escherichia coli Ribosome

Toxins
Mirabilis antiviral protein (MAP) is the type I ribosome-inactivating protein (RIP), which consists of an RNA N-glycosylase domain with no carbohydrate-binding domain.
Nanami Nishida, Yuki Ninomiya, Toru Yoshida, Takehito Tanzawa, Yasushi Maki, Hideji Yoshida, Hideaki Tsuge, Noriyuki Habuka   +7 more
doaj   +1 more source