Biological Activities of Ribosome-Inactivating Proteins [PDF]
Toxins, 2023 After more than 50 years of research, studies on the structure and biological activities of ribosome-inactivating proteins (RIPs) continue to provide a field of great interest within the scientific community, both for the health risks they pose and their
Lucía Citores, José M. Ferreras
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Antiviral Activity of Ribosome-Inactivating Proteins [PDF]
Toxins, 2021 Ribosome-inactivating proteins (RIPs) are rRNA N-glycosylases from plants (EC 3.2.2.22) that inactivate ribosomes thus inhibiting protein synthesis. The antiviral properties of RIPs have been investigated for more than four decades.
Lucía Citores +2 more
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Ribosome Inactivating Proteins from Rosaceae [PDF]
Molecules, 2016 Ribosome-inactivating proteins (RIPs) are widespread among higher plants of different taxonomic orders. In this study, we report on the RIP sequences found in the genome/transcriptome of several important Rosaceae species, including many economically ...
Chenjing Shang +2 more
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Antifungal Activity of Ribosome-Inactivating Proteins [PDF]
ToxinsThe control of crop diseases caused by fungi remains a major problem and there is a need to find effective fungicides that are environmentally friendly.
Rosario Iglesias +3 more
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Special Issue: Ribosome-Inactivating Proteins—Commemorative Issue in Honor of Professor Fiorenzo Stirpe [PDF]
Molecules, 2017 The family of ribosome-inactivating proteins (RIPs) groups all enzymes (EC.3.2.2.22) with a so-called RIP domain which comprises N-glycosidase activity and enables these proteins to catalytically inactivate ribosomes.[...]
Els J.M. Van Damme
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Extensive Evolution of Cereal Ribosome-Inactivating Proteins Translates into Unique Structural Features, Activation Mechanisms, and Physiological Roles [PDF]
Toxins, 2017 Ribosome-inactivating proteins (RIPs) are a class of cytotoxic enzymes that can depurinate rRNAs thereby inhibiting protein translation. Although these proteins have also been detected in bacteria, fungi, and even some insects, they are especially ...
Jeroen De Zaeytijd, Els J. M. Van Damme
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Ribosome-Inactivating Proteins from Plants: A Historical Overview [PDF]
Molecules, 2016 This review provides a historical overview of the research on plant ribosome-inactivating proteins (RIPs), starting from the first studies at the end of eighteenth century involving the purification of abrin and ricin, as well as the immunological ...
Andrea Bolognesi +4 more
doaj +5 more sources
The ribosome-inactivating proteins MAP30 and Momordin inhibit SARS-CoV-2 [PDF]
PLoS ONE, 2023 The continuing emergence of SARS-CoV-2 variants has highlighted the need to identify additional points for viral inhibition. Ribosome inactivating proteins (RIPs), such as MAP30 and Momordin which are derived from bitter melon (Momordica charantia), have
Norman R. Watts +7 more
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Engineering of Ribosome-inactivating Proteins for Improving Pharmacological Properties [PDF]
Toxins, 2020 Ribosome-inactivating proteins (RIPs) are N-glycosidases, which depurinate a specific adenine residue in the conserved α-sarcin/ricin loop (α-SRL) of rRNA.
Jia-Qi Lu +3 more
doaj +2 more sources
Structures and Ribosomal Interaction of Ribosome-Inactivating Proteins [PDF]
Molecules, 2016 Ribosome-inactivating proteins (RIPs) including ricin, Shiga toxin, and trichosanthin, are RNA N-glycosidases that depurinate a specific adenine residue (A-4324 in rat 28S ribosomal RNA, rRNA) in the conserved α-sarcin/ricin loop (α-SRL) of rRNA.
Wei-Wei Shi +3 more
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