Results 1 to 10 of about 13,819 (234)

Ribosome inactivation by Escherichia coli GTPase RsgA inhibits T4 phage

Frontiers in Microbiology, 2023
IntroductionBacteria must combat phages, and myriad bacterial anti-phage systems have been discovered that reduce host metabolism, for example, by depleting energetic compounds like ATP and NAD+. Hence, these systems indirectly inhibit protein production.
Laura Fernández-García, Laura Fernández-García, María Tomás, Thomas K. Wood   +3 more
doaj   +1 more source

The Recombinant Maize Ribosome-Inactivating Protein Transiently Reduces Viral Load in SHIV89.6 Infected Chinese Rhesus Macaques

Toxins, 2015
Ribosome inactivating proteins (RIPs) inhibit protein synthesis by depurinating the large ribosomal RNA and some are found to possess anti-human immunodeficiency virus (HIV) activity. Maize ribosome inactivating protein (RIP) has an internal inactivation
Rui-Rui Wang, Ka-Yee Au, Hong-Yi Zheng, Liang-Min Gao, Xuan Zhang, Rong-Hua Luo, Sue Ka-Yee Law, Amanda Nga-Sze Mak, Kam-Bo Wong, Ming-Xu Zhang, Wei Pang, Gao-Hong Zhang, Pang-Chui Shaw, Yong-Tang Zheng   +13 more
doaj   +1 more source

Antifungal Activity of Ageritin, a Ribotoxin-like Protein from Cyclocybe aegerita Edible Mushroom, against Phytopathogenic Fungi

Toxins, 2023
Ageritin from poplar mushrooms is a specific endonuclease that hydrolyzes a single phosphodiester bond located in the sarcin-ricin loop (SRL) of the large rRNA, thereby blocking protein synthesis.
Sara Ragucci, Stefany Castaldi, Nicola Landi, Rachele Isticato, Antimo Di Maro   +4 more
doaj   +1 more source

Use of Ribosome-Inactivating Proteins from Sambucus for the Construction of Immunotoxins and Conjugates for Cancer Therapy

Toxins, 2011
The type 2 ribosome-inactivating proteins (RIPs) isolated from some species belonging to the Sambucus genus, have the characteristic that although being even more active than ricin inhibiting protein synthesis in cell-free extracts, they lack the high ...
Pilar Jiménez, Tomás Girbés, Rosario Iglesias, Lucía Citores, José M. Ferreras   +4 more
doaj   +1 more source

Phytochemistry and Biological Activities of Agrostemma Genus—A Review

Plants
The family Caryophyllaceae comprises more than 2600 species spread widely across all the continents. Their economic importance is mainly as ornamentals (carnation) and as weeds in agriculture. Some species have been used traditionally (and some are still)
Aleksander Smakosz, Adam Matkowski, Izabela Nawrot-Hadzik   +2 more
doaj   +1 more source

Small-molecule inhibitor leads of ribosome-inactivating proteins developed using the doorstop approach. [PDF]

PLoS ONE, 2011
Ribosome-inactivating proteins (RIPs) are toxic because they bind to 28S rRNA and depurinate a specific adenine residue from the α-sarcin/ricin loop (SRL), thereby inhibiting protein synthesis.
Yuan-Ping Pang, Jewn Giew Park, Shaohua Wang, Anuradha Vummenthala, Rajesh K Mishra, John E McLaughlin, Rong Di, Jennifer Nielsen Kahn, Nilgun E Tumer, Laszlo Janosi, Jon Davis, Charles B Millard   +11 more
doaj   +1 more source

LRP1-Mediated Endocytosis May Be the Main Reason for the Difference in Cytotoxicity of Curcin and Curcin C on U2OS Osteosarcoma Cells

Toxins, 2022
Curcin and Curcin C, both of the ribosome-inactivating proteins of Jatropha curcas, have apparent inhibitory effects on the proliferation of osteosarcoma cell line U20S.
Siying Qin, Xueying Wang, Pan Han, Zhiping Lai, Yingying Ren, Rui Ma, Cheng Cheng, Ting Wang, Ying Xu   +8 more
doaj   +1 more source

In-silico analysis of ribosome inactivating protein (RIP) of the Cucurbitaceae family

AMB Express
Ribosome-inactivating proteins (RIPs) are highly active N-glycosidases that depurinate both bacterial and eukaryotic rRNAs, halting protein synthesis during translation.
Quratulain Maqsood, Aleena Sumrin, Qurban Ali, Nazim Hussain, Saif Ul Malook, Daoud Ali   +5 more
doaj   +1 more source

Kirkiin: A New Toxic Type 2 Ribosome-Inactivating Protein from the Caudex of Adenia kirkii

Toxins, 2021
Ribosome-inactivating proteins (RIPs) are plant toxins that irreversibly damage ribosomes and other substrates, thus causing cell death. RIPs are classified in type 1 RIPs, single-chain enzymatic proteins, and type 2 RIPs, consisting of active A chains ...
Massimo Bortolotti, Stefania Maiello, José M. Ferreras, Rosario Iglesias, Letizia Polito, Andrea Bolognesi   +5 more
doaj   +1 more source

Arabidopsis Bax Inhibitor-1 inhibits cell death induced by pokeweed antiviral protein in Saccharomyces cerevisae

Microbial Cell, 2015
Apoptosis is an active form of programmed cell death (PCD) that plays critical roles in the development, differentiation and resistance to pathogens in multicellular organisms. Ribosome inactivating proteins (RIPs) are able to induce apoptotic cell death
Birsen Çakır, Nilgun E. Tumer
doaj   +1 more source