The Plant Ribosome-Inactivating Proteins Play Important Roles in Defense against Pathogens and Insect Pest Attacks [PDF]
Frontiers in Plant Science, 2018 Ribosome-inactivating proteins (RIPs) are toxic N-glycosidases that depurinate eukaryotic and prokaryotic rRNAs, thereby arresting protein synthesis during translation. RIPs are widely found in various plant species and within different tissues.
Feng Zhu +3 more
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Extensive Evolution of Cereal Ribosome-Inactivating Proteins Translates into Unique Structural Features, Activation Mechanisms, and Physiological Roles [PDF]
Toxins, 2017 Ribosome-inactivating proteins (RIPs) are a class of cytotoxic enzymes that can depurinate rRNAs thereby inhibiting protein translation. Although these proteins have also been detected in bacteria, fungi, and even some insects, they are especially ...
Jeroen De Zaeytijd, Els J. M. Van Damme
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Ribosome-Inactivating Proteins: From Plant Defense to Tumor Attack [PDF]
Toxins, 2010 Ribosome-inactivating proteins (RIPs) are EC3.2.32.22 N-glycosidases that recognize a universally conserved stem-loop structure in 23S/25S/28S rRNA, depurinating a single adenine (A4324 in rat) and irreversibly blocking protein translation, leading ...
Maria Serena Fabbrini +3 more
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Plant Ribosome-Inactivating Proteins: Progesses, Challenges and Biotechnological Applications (and a Few Digressions) [PDF]
Toxins, 2017 Plant ribosome-inactivating protein (RIP) toxins are EC3.2.2.22 N-glycosidases, found among most plant species encoded as small gene families, distributed in several tissues being endowed with defensive functions against fungal or viral infections.
Maria Serena Fabbrini +3 more
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Structure and Biological Properties of Ribosome-Inactivating Proteins and Lectins from Elder (Sambucus nigra L.) Leaves. [PDF]
Toxins (Basel), 2022 Iglesias R +8 more
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Ribosome inactivating proteins from plants inhibiting viruses. [PDF]
Virol Sin, 2011 Many plants contain ribosome inactivating proteins (RIPs) with N-glycosidase activity, which depurinate large ribosomal RNA and arrest protein synthesis. RIPs so far tested inhibit replication of mRNA as well as DNA viruses and these proteins, isolated from plants, are found to be effective against a broad range of viruses such as human ...
Kaur I, Gupta RC, Puri M.
europepmc +4 more sources
Hyperuricaemia, Xanthine Oxidoreductase and Ribosome‐Inactivating Proteins from Plants: The Contributions of Fiorenzo Stirpe to Frontline Research [PDF]
Molecules, 2017 The enzymes called ribosome‐inactivating proteins (RIPs) that are able to depurinate nucleic acids and arrest vital cellular functions, including protein synthesis, are still a frontline research field, mostly because of their promising medical ...
Andrea Bolognesi +3 more
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Analysis of castor bean ribosome-inactivating proteins and their gene expression during seed development [PDF]
Genetics and Molecular Biology, 2013 Ribosome-inactivating proteins (RIPs) are enzymes that inhibit protein synthesis after depurination of a specific adenine in rRNA. The RIP family members are classified as type I RIPs that contain an RNA-N-glycosidase domain and type II RIPs that contain
Guilherme Loss-Morais +7 more
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Chemical structure of Retro-2, a compound that protects cells against ribosome-inactivating proteins. [PDF]
Sci Rep, 2012 Park JG, Kahn JN, Tumer NE, Pang YP.
europepmc +3 more sources
Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins. [PDF]
Chin J Cancer, 2015 Zeng M +5 more
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