Results 41 to 50 of about 13,819 (234)
Toxins, 2022 Targeted toxins (TT) for cancer treatment are a class of hybrid biologic comprised of a targeting domain coupled chemically or genetically to a proteinaceous toxin payload.
David J. Flavell, Sopsamorn U. Flavell
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Suicide nanoplasmids coding for ribosome-inactivating proteins [PDF]
European Journal of Pharmaceutical Sciences, 2022 Conventional eukaryotic expression plasmids contain a DNA backbone that is dispensable for the cellular expression of the transgene. In order to reduce the vector size, minicircle DNA technology was introduced. A drawback of the minicircle technology are considerable production costs.
Mitdank, Hardy +8 more
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Maize ribosome-inactivating protein uses Lys158-lys161 to interact with ribosomal protein P2 and the strength of interaction is correlated to the biological activities. [PDF]
PLoS ONE, 2012 Ribosome-inactivating proteins (RIPs) inactivate prokaryotic or eukaryotic ribosomes by removing a single adenine in the large ribosomal RNA. Here we show maize RIP (MOD), an atypical RIP with an internal inactivation loop, interacts with the ribosomal ...
Yuen-Ting Wong +5 more
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Ribosome inactivating proteins and apoptosis
FEBS Letters, 2005 Ribosome inactivating proteins (RIPs) are protein toxins that are of plant or microbial origin that inhibit protein synthesis by inactivating ribosomes. Recent studies suggest that RIPs are also capable of inducing cell death by apoptosis. Though many reports are available on cell death induced by RIPs, the mechanism involved is not well studied ...
Narayanan, Sriram +4 more
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Toxins, 2022 Ricin is a toxin which enters cells and depurinates an adenine base in the sarcin-ricin loop in the large ribosomal subunit, leading to the inhibition of protein translation and cell death.
Yan Ryan +6 more
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Toxins, 2016 Endoglin (CD105) is an accessory component of the TGF-β receptor complex, which is expressed in a number of tissues and over-expressed in the endothelial cells of tumor neovasculature.
Begoña Barriuso +7 more
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Combination of Balsamin and Flavonoids Induce Apoptotic Effects in Liver and Breast Cancer Cells
Frontiers in Pharmacology, 2020 Flavonoids such as naringenin, quercetin, and naringin are known to exhibit anticancer properties. In this study, we examined the effects of these flavonoids on cell viability and apoptotic pathways of cancer cells, either singly or in combination with ...
Parminder K. Ajji +3 more
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Plant Toxins as Potential Alternatives to Botulinum Toxin for Eye-Movement Disorder Therapy
Stresses, 2023 The most successful alternative to traditional surgery for ocular muscle spasm treatment is the intramuscular injection of botulinum toxin (BTX), which allows the maintenance of the muscle dynamics and the absence of scars.
Massimo Bortolotti +5 more
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Ribosome‐inactivating proteins up to date
FEBS Letters, 1986 Ribosome‐inactivating proteins (RIPs) from plants inactivate eukaryotic ribosomes, as far as studied by rendering their 60 S subunit unable to bind elongation factor 2. These proteins seem widely distributed and possibly ubiquitous in plants. They are either type 1, those consisting of a single polypeptide chain, or type 2 (ricin and related toxins ...
Stirpe, Fiorenzo, Barbieri, Luigi
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Effect of transgenic tobacco plant, Nicotiana tabacum expressing ribosome inactivating gene isolated from the bulbs of Dutch iris, Iris hollandica on biological parameters of Myzus nicotianae (Hem.: Aphididea) and Spodoptera exigua (Lep.: Noctuidae) [PDF]
نامه انجمن حشرهشناسی ایران, 2015 The use of modified crop plants through gene transfer between different plant species plays an important role in pest control programs. We have investigated the insecticidal properties of two lines of tobacco transgenic plant consisting of IRIP ...
Sh. Shahidi-Noghabi
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