Results 11 to 20 of about 406,930 (327)
Impact of Ribosome Activity on SARS-CoV-2 LNP – Based mRNA Vaccines
Frontiers in Molecular Biosciences, 2021 Coronavirus-related Severe Acute Respiratory Syndrome-2 (SARS-CoV-2) initially was detected in Wuhan, Hubei, China. Since early 2021, World Health Organization (WHO) has declared Coronavirus Disease 2019 (COVID-19) a pandemic due to rapidly transformed ...
Evangelos Tsiambas +11 more
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Separation and Paired Proteome Profiling of Plant Chloroplast and Cytoplasmic Ribosomes
Plants, 2020 Conventional preparation methods of plant ribosomes fail to resolve non-translating chloroplast or cytoplasmic ribosome subunits from translating fractions.
Alexandre Augusto Pereira Firmino +7 more
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RNA Biology, 2022 Cells of metazoans respond to internal and external stressors by activating stress response pathways that aim for re-establishing cellular homoeostasis or, if this cannot be achieved, triggering programmed cell death. Problems during translation, arising
Soumasree De, Oliver Mühlemann
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Ribosome heterogeneity and specialization in development
Wiley Interdisciplinary Reviews - RNA, 2021 Regulation of protein synthesis is a vital step in controlling gene expression, especially during development. Over the last 10 years, it has become clear that rather than being homogeneous machines responsible for mRNA translation, ribosomes are highly ...
K. Norris, T. Hopes, J. Aspden
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Characterization of HicAB toxin-antitoxin module of Sinorhizobium meliloti
BMC Microbiology, 2019 Background Toxin-antitoxin (TA) systems are little genetic units generally composed of two genes encoding antitoxin and toxin. These systems are known to be involved in many functions that can lead to growth arrest and cell death.
Manon Thomet +3 more
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Homeostatic Roles of the Proteostasis Network in Dendrites
Frontiers in Cellular Neuroscience, 2020 Cellular protein homeostasis, or proteostasis, is indispensable to the survival and function of all cells. Distinct from other cell types, neurons are long-lived, exhibiting architecturally complex and diverse multipolar projection morphologies that can ...
Erin N. Lottes, Daniel N. Cox
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The dark side of the ribosome life cycle
RNA Biology, 2022 Thanks to genetics, biochemistry, and structural biology many features of the ribosome´s life cycles in models of bacteria, eukaryotes, and some organelles have been revealed to near-atomic details.
Sébastien Ferreira-Cerca
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Molecules, 2013 Introduction of reporter groups at designed RNA sites is a widely accepted approach to gain information about the molecular environment of RNAs in their complexes with other biopolymers formed during various cellular processes.
Dmitri Graifer, Galina Karpova
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Genome-wide Survey of Ribosome Collision
Cell Reports, 2020 Summary: Ribosome movement is not always smooth and is rather often impeded. For ribosome pauses, fundamental issues remain to be addressed, including where ribosomes pause on mRNAs, what kind of RNA/amino acid sequence causes this pause, and the ...
Peixun Han +10 more
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RNA Biology, 2023 Lamotrigine (Ltg), an anticonvulsant drug, targets initiation factor 2 (IF2), compromises ribosome biogenesis and causes toxicity to Escherichia coli. However, our understanding of Ltg toxicity in E. coli remains unclear. While our in vitro assays reveal
Sudhir Singh +6 more
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