Results 11 to 20 of about 254,623 (219)
Ribosome-omics of the human ribosome [PDF]
RNA, 2014 The torrent of RNA-seq data becoming available not only furnishes an overview of the entire transcriptome but also provides tools to focus on specific areas of interest. Our focus on the synthesis of ribosomes asked whether the abundance of mRNAs encoding ribosomal proteins (RPs) matched the equimolar need for the RPs in the assembly of ribosomes.
Jonathan R. Warner, Varun Gupta
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Novel mRNA-specific effects of ribosome drop-off on translation rate and polysome profile. [PDF]
PLoS Computational Biology, 2017 The well established phenomenon of ribosome drop-off plays crucial roles in translational accuracy and nutrient starvation responses during protein translation.
Pierre Bonnin +4 more
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Bacterial Ribosome Rescue Systems
Microorganisms, 2022 To maintain proteostasis, the cell employs multiple ribosome rescue systems to relieve the stalled ribosome on problematic mRNA. One example of problematic mRNA is non-stop mRNA that lacks an in-frame stop codon produced by endonucleolytic cleavage or ...
Daisuke Kurita, Hyouta Himeno
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Ribosome biogenesis in disease: new players and therapeutic targets
Signal Transduction and Targeted Therapy, 2023 The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome biogenesis is the process that generates ribosomes and plays an essential role in cell proliferation, differentiation, apoptosis, development, and transformation. The mTORC1,
Lijuan Jiao +7 more
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Mechanisms of ribosome recycling in bacteria and mitochondria: a structural perspective
RNA Biology, 2022 In all living cells, the ribosome translates the genetic information carried by messenger RNAs (mRNAs) into proteins. The process of ribosome recycling, a key step during protein synthesis that ensures ribosomal subunits remain available for new rounds ...
Savannah M. Seely, Matthieu G. Gagnon
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The channel capacity of the ribosome [PDF]
Phys. Rev. E 108, 044404 (2023), 2023 Translation is one of the most fundamental processes in the biological cell. Because of the central role that translation plays across all domains of life, the enzyme that carries out this process, the ribosome, is required to process information with high accuracy. This accuracy often approaches values near unity experimentally.
arxiv +1 more source
mTORC1 Enhances Early Phase Ribosome Processivity
Frontiers in Molecular Biosciences, 2020 During translation elongation, the ribosome serially adds amino acids to a growing polypeptide over many rounds of catalysis. The ribosome remains bound to mRNAs over these multiple catalytic cycles, requiring high processivity. Despite its importance to
Erin An, Kyle Friend
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Impact of Ribosome Activity on SARS-CoV-2 LNP – Based mRNA Vaccines
Frontiers in Molecular Biosciences, 2021 Coronavirus-related Severe Acute Respiratory Syndrome-2 (SARS-CoV-2) initially was detected in Wuhan, Hubei, China. Since early 2021, World Health Organization (WHO) has declared Coronavirus Disease 2019 (COVID-19) a pandemic due to rapidly transformed ...
Evangelos Tsiambas +11 more
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Extraribosomal Functions of Cytosolic Ribosomal Proteins in Plants
Frontiers in Plant Science, 2021 Ribosomes are basic translational machines in all living cells. The plant cytosolic ribosome is composed of four rRNAs and approximately 81 ribosomal proteins (RPs). In addition to the fundamental functions of RPs in the messenger RNA decoding process as
Wei Xiong +4 more
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The mitochondrial ribosome and ribosomal RNA of the chick [PDF]
FEBS Letters, 1971 Reports have appeared on large molecular weight RNAs associated with the mitochondria of higher organisms. These include HeLa cells [ 1 ] , BHK-2 1 cells [2] , mouse L-cells [3,4] , rat liver [4, S] and Xenopus ovary [6] . This RNA consists of two predominant species found to be 17 S and 13 S by sedimentation [2, 31 .
Terence H. Rabbitts, T.S. Work
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