HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation. [PDF]
, 2013 The internal ribosome entry site (IRES) of the hepatitis C virus (HCV) drives noncanonical initiation of protein synthesis necessary for viral replication.
A Ben-Shem +68 more
core +1 more source
Hepatitis C virus 3'UTR regulates viral translation through direct interactions with the host translation machinery. [PDF]
, 2013 The 3' untranslated region (3'UTR) of hepatitis C virus (HCV) messenger RNA stimulates viral translation by an undetermined mechanism. We identified a high affinity interaction, conserved among different HCV genotypes, between the HCV 3'UTR and the host ...
Bai, Yun +2 more
core +2 more sources
Identifying ribosome heterogeneity using ribosome profiling
Nucleic Acids Research, 2022 Abstract Recent studies have revealed multiple mechanisms that can lead to heterogeneity in ribosomal composition. This heterogeneity can lead to preferential translation of specific panels of mRNAs, and is defined in large part by the ribosomal protein (RP) content, amongst other things.
Ferhat Alkan +6 more
openaire +6 more sources
Cotranslational folding of proteins on the ribosome.
, 2020 Many proteins in the cell fold cotranslationally within the restricted space of the polypeptide exit tunnel or at the surface of the ribosome. A growing body of evidence suggests that the ribosome can alter the folding trajectory in many different ways ...
Liutkute, M., Rodnina, M., Samatova, E.
core +1 more source
The inhibition of ribosomal ribonuclease by bacterial ribosomes [PDF]
Biochemical Journal, 1965 1. A comparison has been made between the ribonuclease activities of untreated ribosomes from Escherichia coli B and Pseudomonas fluorescens and the activities of ribosomes on to which ribosomal ribonuclease from E. coli B has been adsorbed. 2. The normal ribosomes from both species were stable in 5-10mm-Mg(2+) (I0.16) at pH6. The RNA in ribosomes from
HE Wade, HK Robinson
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The 73 S ribosome of Neurospora crassa is the native mitochondrial ribosome [PDF]
, 1977 The effect of the inclusion of EDTA and of heparin, in media used in the isolation of mitochondria, on the mitochindrial previous termribosomenext term has been investigated. 1. 1.
Adelmann +24 more
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Multiple prebiotic metals mediate translation. [PDF]
, 2018 Today, Mg2+ is an essential cofactor with diverse structural and functional roles in life's oldest macromolecular machine, the translation system. We tested whether ancient Earth conditions (low O2, high Fe2+, and high Mn2+) can revert the ribosome to a ...
Bowman, Jessica C +8 more
core +1 more source
, 2011 Ribosome is a molecular machine that polymerizes a protein where the sequence of the amino acid residues, the monomers of the protein, is dictated by the sequence of codons (triplets of nucleotides) on a messenger RNA (mRNA) that serves as the template ...
Ajeet K Sharma +10 more
core +1 more source
Extensive evolution of cereal ribosome-inactivating proteins translates into unique structural features, activation mechanisms, and physiological roles [PDF]
, 2017 Ribosome-inactivating proteins (RIPs) are a class of cytotoxic enzymes that can depurinate rRNAs thereby inhibiting protein translation. Although these proteins have also been detected in bacteria, fungi, and even some insects, they are especially ...
De Zaeytijd, Jeroen, Van Damme, Els
core +2 more sources
Global analysis of gene expression reveals mRNA superinduction is required for the inducible immune response to a bacterial pathogen. [PDF]
, 2017 The inducible innate immune response to infection requires a concerted process of gene expression that is regulated at multiple levels. Most global analyses of the innate immune response have focused on transcription induced by defined immunostimulatory ...
Barry, Kevin C +2 more
core +3 more sources