Results 41 to 50 of about 244,255 (294)

A binding site for the antibiotic GE81112 in the ribosomal mRNA channel

mBio
The initiation phase is the rate-limiting step of protein synthesis (translation) and is finely regulated, making it an important drug target. In bacteria, initiation is guided by three initiation factors and involves positioning the start site on the ...
Andreas Schedlbauer, Xu Han, Wouter van Bakel, Tatsuya Kaminishi, Borja Ochoa-Lizarralde, Idoia Iturrioz, Retina Çapuni, Ransford Parry, Ronny Zegarra, David Gil-Carton, Jorge P. López-Alonso, Kristina Barragan Sanz, Letizia Brandi, Claudio O. Gualerzi, Paola Fucini, Sean R. Connell   +15 more
doaj   +1 more source

Ribosomal Proteins in Ribosome Assembly

Biomolecules
Ribosomes are the cellular machinery responsible for translating mRNA into proteins, a process fundamental to all domains of life from bacteria to eukaryotes [...]
Brigitte Pertschy, Ingrid Zierler
openaire   +3 more sources

A Complementary Mechanism of Bacterial mRNA Translation Inhibition by Tetracyclines

Frontiers in Microbiology, 2021
Tetracycline has positively impacted human health as well as the farming and animal industries. Its extensive usage and versatility led to the spread of resistance mechanisms followed by the development of new variants of the antibiotic.
Victor Barrenechea, Victor Barrenechea, Maryhory Vargas-Reyes, Miguel Quiliano, Pohl Milón   +4 more
doaj   +1 more source

Ribosome Builder: A software project to simulate the ribosome

Computational Biology and Chemistry, 2005
The Ribosome Builder is a software project that provides tools and techniques to create dynamic models of macromolecular systems from the rapidly growing numbers of atomic structural models. It includes a computer program that allows the user to assemble the multiple molecular components within a 3D space and to define the hypothetical interactions of ...
William Knight, Walter Hill, J. Stephen Lodmell   +2 more
openaire   +3 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

The Bowen–Conradi syndrome protein Nep1 (Emg1) has a dual role in eukaryotic ribosome biogenesis, as an essential assembly factor and in the methylation of Psi1191 in yeast 18S rRNA [PDF]

, 2010
The Nep1 (Emg1) SPOUT-class methyltransferase is an essential ribosome assembly factor and the human Bowen–Conradi syndrome (BCS) is caused by a specific Nep1D86G mutation. We recently showed in vitro that Methanocaldococcus jannaschii Nep1 is a sequence-
Valeska Schilling, Jan Philip Wurm, Britta Meyer, Michael Karas, Kötter, Peter, Bahr, Ute, Schilling, Valeska, Buchhaupt, Markus, Wöhnert, Jens, Ute Bahr, Karl-Dieter Entian, Matthias S. Leisegang, Karas, Michael (Prof. Dr.), Martin Held, Heckel, Alexander, Leisegang, Matthias S., Peter Kötter, Markus T. Bohnsack, Entian, Karl-Dieter, Markus Buchhaupt, Bohnsack, Markus, Held, Martin, Alexander Heckel, Meyer, Britta, Leisegang, Matthias, Jens Wöhnert, Karas, Michael, Wurm, Jan Philip   +27 more
core   +1 more source

Direct measurement of the mechanical work during translocation by the ribosome

eLife, 2014
A detailed understanding of tRNA/mRNA translocation requires measurement of the forces generated by the ribosome during this movement. Such measurements have so far remained elusive and, thus, little is known about the relation between force and ...
Tingting Liu, Ariel Kaplan, Lisa Alexander, Shannon Yan, Jin-Der Wen, Laura Lancaster, Charles E Wickersham, Kurt Fredrick, Harry Noller, Ignacio Tinoco Jr, Carlos J Bustamante   +10 more
doaj   +1 more source

The coordinated management of ribosome and translation during injury and regeneration

Frontiers in Cell and Developmental Biology, 2023
Diverse acute and chronic injuries induce damage responses in the gastrointestinal (GI) system, and numerous cell types in the gastrointestinal tract demonstrate remarkable resilience, adaptability, and regenerative capacity in response to stress ...
Thanh Nguyen, Jason C. Mills, Jason C. Mills, Jason C. Mills, Charles J. Cho   +4 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Identification of the prebiotic translation apparatus within the contemporary ribosome [PDF]

, 2009
A structural element that could have existed independently in the prebiotic era was identified at the active site of the contemporary ribosome. It is suggested to have functioned as a proto-ribosome catalyzing peptide bond formation and non-coded ...
Chen Davidovich, Ada Yonath, Ilana Agmon, Anat Bashan   +3 more
core