Results 21 to 30 of about 244,255 (294)
The dark side of the ribosome life cycle
RNA Biology, 2022 Thanks to genetics, biochemistry, and structural biology many features of the ribosome´s life cycles in models of bacteria, eukaryotes, and some organelles have been revealed to near-atomic details.
Sébastien Ferreira-Cerca
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Genome-wide Survey of Ribosome Collision
Cell Reports, 2020 Summary: Ribosome movement is not always smooth and is rather often impeded. For ribosome pauses, fundamental issues remain to be addressed, including where ribosomes pause on mRNAs, what kind of RNA/amino acid sequence causes this pause, and the ...
Peixun Han +10 more
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RNA Biology, 2023 Lamotrigine (Ltg), an anticonvulsant drug, targets initiation factor 2 (IF2), compromises ribosome biogenesis and causes toxicity to Escherichia coli. However, our understanding of Ltg toxicity in E. coli remains unclear. While our in vitro assays reveal
Sudhir Singh +6 more
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Translation inhibitory elements from Hoxa3 and Hoxa11 mRNAs use uORFs for translation inhibition
eLife, 2021 During embryogenesis, Hox mRNA translation is tightly regulated by a sophisticated molecular mechanism that combines two RNA regulons located in their 5’UTR. First, an internal ribosome entry site (IRES) enables cap-independent translation.
Fatima Alghoul +3 more
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Mass spectrometry of ribosomes and ribosomal subunits [PDF]
Proceedings of the National Academy of Sciences, 1998 Nanoflow electrospray ionization has been used to introduce intact Escherichia coli ribosomes into the ion source of a mass spectrometer. Mass spectra of remarkable quality result from a partial, but selective, dissociation of the particles within the mass spectrometer.
Benjamin, DR +4 more
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Protein folding on the ribosome studied using NMR spectroscopy [PDF]
, 2013 NMR spectroscopy is a powerful tool for the investigation of protein folding and misfolding, providing a characterization of molecular structure, dynamics and exchange processes, across a very wide range of timescales and with near atomic resolution.
Christodoulou, J +9 more
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eLife, 2021 The ability to regulate DNA replication initiation in response to changing nutrient conditions is an important feature of most cell types. In bacteria, DNA replication is triggered by the initiator protein DnaA, which has long been suggested to respond ...
Michele Felletti +3 more
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40S ribosome biogenesis co-factors are essential for gametophyte and embryo development [PDF]
, 2013 Ribosome biogenesis is well described in Saccharomyces cerevisiae. In contrast only very little information is available on this pathway in plants. This study presents the characterization of five putative protein co-factors of ribosome biogenesis in ...
Roman Martin +22 more
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eLife, 2022 Rapid and accurate mRNA translation requires efficient codon-dependent delivery of the correct aminoacyl-tRNA (aa-tRNA) to the ribosomal A site. In mammals, this fidelity-determining reaction is facilitated by the GTPase elongation factor-1 alpha (eEF1A),
Manuel F Juette +9 more
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The small-subunit processome is a ribosome assembly intermediate [PDF]
, 2004 The small-subunit (SSU) processome is a large ribonucleoprotein required for the biogenesis of the 18S rRNA and likely corresponds to the terminal knobs visualized by electron microscopy on the 5' end of nascent rRNAs.
Granneman, Sander; id_orcid +4 more
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