Results 11 to 20 of about 247,874 (255)

MiR-662 impairs C/D box snoRNA expression and rRNA 2′-O-ribose methylation marks [PDF]

BJC Reports
Background MiR-662 overexpression has been reported to promote breast cancer metastatic progression and to impair the expression of genes encoding for proteins involved in translation, ribosome biogenesis and ribosome processing (Puppo et al., 2023 ...
Charlotte Filossi, Caroline Isaac, Mariam Jaafar, Philippe Clézardin, Caroline Moyret-Lalle, Virginie Marcel, Margherita Puppo   +6 more
doaj   +2 more sources

Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design

, 2018
Genetic information is translated into proteins by the ribosome. Structural studies of the ribosome and of its complexes with factors and inhibitors have provided invaluable information on the mechanism of protein synthesis.
Thomas A. Steitz, Yury S. Polikanov (6453461), Lin, Jinzhong, Dejian Zhou (1287837), Jinzhong Lin, Steitz, Thomas A., Jinzhong Lin (189430), Dejian Zhou, Polikanov, Yury S., Matthieu G. Gagnon, Thomas A. Steitz (1275207), Zhou, Dejian, Gagnon, Matthieu G., Matthieu G. Gagnon (7935944), Yury S. Polikanov   +14 more
core   +5 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer. [PDF]

Mol Oncol
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Kim A, Aslam M, Torruella E, Sony A, Rahman A, Smith S, de la Parra C, Sauane M.   +7 more
europepmc   +2 more sources

Novel mRNA-specific effects of ribosome drop-off on translation rate and polysome profile. [PDF]

PLoS Computational Biology, 2017
The well established phenomenon of ribosome drop-off plays crucial roles in translational accuracy and nutrient starvation responses during protein translation.
Pierre Bonnin, Norbert Kern, Neil T Young, Ian Stansfield, M Carmen Romano   +4 more
doaj   +1 more source

Mechanisms of ribosome recycling in bacteria and mitochondria: a structural perspective

RNA Biology, 2022
In all living cells, the ribosome translates the genetic information carried by messenger RNAs (mRNAs) into proteins. The process of ribosome recycling, a key step during protein synthesis that ensures ribosomal subunits remain available for new rounds ...
Savannah M. Seely, Matthieu G. Gagnon
doaj   +1 more source

Ribosome biogenesis in disease: new players and therapeutic targets

Signal Transduction and Targeted Therapy, 2023
The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome biogenesis is the process that generates ribosomes and plays an essential role in cell proliferation, differentiation, apoptosis, development, and transformation. The mTORC1,
Lijuan Jiao, Yuzhe Liu, Xi-Yong Yu, Xiangbin Pan, Yu Zhang, Junchu Tu, Yao-Hua Song, Yangxin Li   +7 more
doaj   +1 more source

mTORC1 Enhances Early Phase Ribosome Processivity

Frontiers in Molecular Biosciences, 2020
During translation elongation, the ribosome serially adds amino acids to a growing polypeptide over many rounds of catalysis. The ribosome remains bound to mRNAs over these multiple catalytic cycles, requiring high processivity. Despite its importance to
Erin An, Kyle Friend
doaj   +1 more source

Impact of Ribosome Activity on SARS-CoV-2 LNP – Based mRNA Vaccines

Frontiers in Molecular Biosciences, 2021
Coronavirus-related Severe Acute Respiratory Syndrome-2 (SARS-CoV-2) initially was detected in Wuhan, Hubei, China. Since early 2021, World Health Organization (WHO) has declared Coronavirus Disease 2019 (COVID-19) a pandemic due to rapidly transformed ...
Evangelos Tsiambas, Evangelos Tsiambas, Evangelos Tsiambas, Aristeidis Chrysovergis, Vasileios Papanikolaou, Nicholas Mastronikolis, Vasileios Ragos, Anna Batistatou, Dimitrios Peschos, Nikolaos Kavantzas, Andreas C. Lazaris, Efthimios Kyrodimos   +11 more
doaj   +1 more source

Characterization of HicAB toxin-antitoxin module of Sinorhizobium meliloti

BMC Microbiology, 2019
Background Toxin-antitoxin (TA) systems are little genetic units generally composed of two genes encoding antitoxin and toxin. These systems are known to be involved in many functions that can lead to growth arrest and cell death.
Manon Thomet, Annie Trautwetter, Gwennola Ermel, Carlos Blanco   +3 more
doaj   +1 more source

Separation and Paired Proteome Profiling of Plant Chloroplast and Cytoplasmic Ribosomes

Plants, 2020
Conventional preparation methods of plant ribosomes fail to resolve non-translating chloroplast or cytoplasmic ribosome subunits from translating fractions.
Alexandre Augusto Pereira Firmino, Michal Gorka, Alexander Graf, Aleksandra Skirycz, Federico Martinez-Seidel, Kerstin Zander, Joachim Kopka, Olga Beine-Golovchuk   +7 more
doaj   +1 more source