Results 11 to 20 of about 244,255 (294)

Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design

, 2018
Genetic information is translated into proteins by the ribosome. Structural studies of the ribosome and of its complexes with factors and inhibitors have provided invaluable information on the mechanism of protein synthesis.
Thomas A. Steitz, Yury S. Polikanov (6453461), Lin, Jinzhong, Dejian Zhou (1287837), Jinzhong Lin, Steitz, Thomas A., Jinzhong Lin (189430), Dejian Zhou, Polikanov, Yury S., Matthieu G. Gagnon, Thomas A. Steitz (1275207), Zhou, Dejian, Gagnon, Matthieu G., Matthieu G. Gagnon (7935944), Yury S. Polikanov   +14 more
core   +15 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer. [PDF]

Mol Oncol
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Kim A, Aslam M, Torruella E, Sony A, Rahman A, Smith S, de la Parra C, Sauane M.   +7 more
europepmc   +2 more sources

Ribosome Biogenesis and Cancer: Overview on Ribosomal Proteins [PDF]

International Journal of Molecular Sciences, 2021
Cytosolic ribosomes (cytoribosomes) are macromolecular ribonucleoprotein complexes that are assembled from ribosomal RNA and ribosomal proteins, which are essential for protein biosynthesis. Mitochondrial ribosomes (mitoribosomes) perform translation of the proteins essential for the oxidative phosphorylation system. The biogenesis of cytoribosomes and
Pecoraro Annalisa, Pagano Martina, Russo Giulia, Russo Annapina   +3 more
openaire   +3 more sources

Ribosome-omics of the human ribosome [PDF]

RNA, 2014
The torrent of RNA-seq data becoming available not only furnishes an overview of the entire transcriptome but also provides tools to focus on specific areas of interest. Our focus on the synthesis of ribosomes asked whether the abundance of mRNAs encoding ribosomal proteins (RPs) matched the equimolar need for the RPs in the assembly of ribosomes.
Gupta, Varun, Warner, Jonathan R.
openaire   +2 more sources

Ribosomal proteins: functions beyond the ribosome [PDF]

Journal of Molecular Cell Biology, 2015
Although ribosomal proteins are known for playing an essential role in ribosome assembly and protein translation, their ribosome-independent functions have also been greatly appreciated. Over the past decade, more than a dozen of ribosomal proteins have been found to activate the tumor suppressor p53 pathway in response to ribosomal stress. In addition,
Xiang, Zhou, Wen-Juan, Liao, Jun-Ming, Liao, Peng, Liao, Hua, Lu   +4 more
openaire   +2 more sources

The mitochondrial ribosome and ribosomal RNA of the chick [PDF]

FEBS Letters, 1971
Reports have appeared on large molecular weight RNAs associated with the mitochondria of higher organisms. These include HeLa cells [ 1 ] , BHK-2 1 cells [2] , mouse L-cells [3,4] , rat liver [4, S] and Xenopus ovary [6] . This RNA consists of two predominant species found to be 17 S and 13 S by sedimentation [2, 31 .
Rabbitts, Terence H., Work, T.S.
openaire   +2 more sources

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation. [PDF]

FEBS Open Bio
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Nakata E, Li Y, Endo K, Ito K.
europepmc   +2 more sources

The inhibition of ribosomal ribonuclease by bacterial ribosomes [PDF]

Biochemical Journal, 1965
1. A comparison has been made between the ribonuclease activities of untreated ribosomes from Escherichia coli B and Pseudomonas fluorescens and the activities of ribosomes on to which ribosomal ribonuclease from E. coli B has been adsorbed. 2. The normal ribosomes from both species were stable in 5-10mm-Mg(2+) (I0.16) at pH6. The RNA in ribosomes from
H E, Wade, H K, Robinson
openaire   +2 more sources

2A-induced ribosome stalling [PDF]

, 2014
Originally 2A was characterised in foot-and-mouth disease virus. Site directed mutagenesis identified a C-terminus consensus motif [D(V/I)ExNPGP] and it is proposed that 2A interacts with the exit tunnel of the ribosome in a way that a specific peptide ...
Odon, Valèrie
core   +1 more source

Homeostatic Roles of the Proteostasis Network in Dendrites

Frontiers in Cellular Neuroscience, 2020
Cellular protein homeostasis, or proteostasis, is indispensable to the survival and function of all cells. Distinct from other cell types, neurons are long-lived, exhibiting architecturally complex and diverse multipolar projection morphologies that can ...
Erin N. Lottes, Daniel N. Cox
doaj   +1 more source