FredHutch/DUX4-IFNg-ribosome-footprints_Zenodo: Zenodo Release
, 2023 Ribosome footprint profiling and translation efficiency analysis for the manuscript titled "DUX4 orchestrates translational reprogramming by broadly suppressing translation ...
Chao-Jen Wong
core +1 more source
NMR snapshots of nascent chains emerging from the ribosome during biosynthesis [PDF]
, 2022 NMR spectroscopy is a powerful tool to study the dynamic process of how proteins acquire their biological fold at near-atomic resolution. Advances in spectroscopic and biochemical approaches have now expanded the ability of NMR methods to probe ...
Sammy HS, Chan +2 more
core +1 more source
Exploring Wells-Dawson Clusters Associated With the Small Ribosomal Subunit
Frontiers in Chemistry, 2019 The polyoxometalate P2W18O626-, the Wells-Dawson cluster, stabilized the ribosome sufficiently for the crystallographers to solve the phase problem and improve the structural resolution.
Debbie C. Crans +3 more
doaj +1 more source
eLife, 2021 Human mitochondria express a genome that encodes thirteen core subunits of the oxidative phosphorylation system (OXPHOS). These proteins insert into the inner membrane co-translationally. Therefore, mitochondrial ribosomes engage with the OXA1L-insertase
Sven Dennerlein +12 more
doaj +1 more source
Expansion of a novel population of NK cells with low ribosome expression in juvenile dermatomyositis
Frontiers in Immunology, 2022 Juvenile dermatomyositis (JDM) is a pediatric autoimmune disease associated with characteristic rash and proximal muscle weakness. To gain insight into differential lymphocyte gene expression in JDM, peripheral blood mononuclear cells from 4 new-onset ...
Kinsey A. Hilliard +7 more
doaj +1 more source
Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation [PDF]
, 2007 A family of HEAT-repeat containing ribosome synthesis factors was previously identified in Saccharomyces cerevisiae. We report the detailed characterization of two of these factors, Utp10 and Utp20, which were initially identified as components of the ...
Tollervey, David +2 more
core +1 more source
A binding site for the antibiotic GE81112 in the ribosomal mRNA channel
mBioThe initiation phase is the rate-limiting step of protein synthesis (translation) and is finely regulated, making it an important drug target. In bacteria, initiation is guided by three initiation factors and involves positioning the start site on the ...
Andreas Schedlbauer +15 more
doaj +1 more source
The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site [PDF]
, 2008 Ribosome biogenesis in eukaryotes requires the participation of a large number of ribosome assembly factors. The highly conserved eukaryotic nucleolar protein Nep1 has an essential but unknown function in 18S rRNA processing and ribosome biogenesis.
Wöhnert, Jens +8 more
core +1 more source
A Complementary Mechanism of Bacterial mRNA Translation Inhibition by Tetracyclines
Frontiers in Microbiology, 2021 Tetracycline has positively impacted human health as well as the farming and animal industries. Its extensive usage and versatility led to the spread of resistance mechanisms followed by the development of new variants of the antibiotic.
Victor Barrenechea +4 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source