Results 61 to 70 of about 244,255 (294)

Ribosome-binding antibiotics increase bacterial longevity and growth efficiency [PDF]

, 2023
Antibiotics, by definition, reduce bacterial growth rates in optimal culture conditions; however, the real-world environments bacteria inhabit see rapid growth punctuated by periods of low nutrient availability. How antibiotics mediate population decline
P Rosenstiel (10993101), T Bergmiller (21894461), R Beardmore (21859385), I Gudelj (21821996), H Schulenburg (21821984), D Ankrett (21953012), E Wood (13486879)   +6 more
core   +3 more sources

Mutational analysis of ribosomal proteins in a cohort of pediatric patients with T-cell acute lymphoblastic leukemia reveals Q123R, a novel mutation in RPL10

Frontiers in Genetics, 2022
T-cell acute lymphoblastic leukemia (T-ALL) is a subtype of ALL involving the malignant expansion of T-cell progenitors. It is driven by a number of different possible genetic lesions, including mutations in genes encoding for ribosomal proteins (RPs ...
Lorenza Bacci, Lorenza Bacci, Valentina Indio, Guglielmo Rambaldelli, Cristina Bugarin, Franco Magliocchetti, Franco Magliocchetti, Alberto Del Rio, Alberto Del Rio, Daniela Pollutri, Daniela Pollutri, Fraia Melchionda, Andrea Pession, Marina Lanciotti, Carlo Dufour, Giuseppe Gaipa, Lorenzo Montanaro, Lorenzo Montanaro, Marianna Penzo, Marianna Penzo   +19 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The origin and evolution of the ribosome [PDF]

, 2010
THE ORIGIN AND EVOLUTION OF THE RIBOSOME Ajith Harish, Ph.D. Program in Physiological and Molecular Plant Biology University of Illinois at Urbana-Champaign, 2010 Prof.
Harish, Ajith
core  

Ribosome-S-D cryo-EM data collection and refinement statistics.

, 2023
Ribosome-S-D cryo-EM data collection and refinement statistics.
Christopher E. Morgan (11269227), Alex B. Green (15503096), Yoon-Suk Kang (10220723), Matthew G. Dowgiallo (5367773), Katherine A. Truelson (15503099), Edward W. Yu (9745721), James E. Kirby (12345360), Lucius Chiaraviglio (44954), Shade Rodriguez (15503102), Katelyn E. Zulauf (5155004), Brandon C. Miller (10170821), Roman Manetsch (691440), Kenneth P. Smith (6914963), Anthony D. Kang (386819)   +13 more
core   +1 more source

The mechanism of error induction by the antibiotic viomycin provides insight into the fidelity mechanism of translation

eLife, 2019
Applying pre-steady state kinetics to an Escherichia-coli-based reconstituted translation system, we have studied how the antibiotic viomycin affects the accuracy of genetic code reading.
Mikael Holm, Chandra Sekhar Mandava, Måns Ehrenberg, Suparna Sanyal   +3 more
doaj   +1 more source

Finding sense in the context

eLife, 2020
Ribosomal profiling has shed new light on how ribosomes can ignore stop codons in messenger RNA.
Kim M Keeling, David M Bedwell
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

The ABCs of the ribosome [PDF]

Nature Structural & Molecular Biology, 2014
An ABC protein that binds the ribosomal exit site suggests a new mechanism for direct regulation of translation in response to changing ATP levels in the cell.
Fredrick, Kurt, Ibba, Michael
openaire   +3 more sources

Antibiotics and the ribosome [PDF]

Molecular Microbiology, 2006
SummaryThe ribosome is one of the main antibiotic targets in the cell. Recent years brought important insights into the mode of interaction of antibiotics with the ribosome and mechanisms of antibiotic action. Ribosome crystallography provided a detailed view of the interactions between antibiotics and rRNA.
Tanel, Tenson, Alexander, Mankin
openaire   +2 more sources