Results 61 to 70 of about 358,575 (311)

Tuning the ribosome: The influence of rRNA modification on eukaryotic ribosome biogenesis and function

RNA Biology, 2016
rRNAs are extensively modified during their transcription and subsequent maturation in the nucleolus, nucleus and cytoplasm. RNA modifications, which are installed either by snoRNA-guided or by stand-alone enzymes, generally stabilize the structure of ...
K. Sloan, Ahmed S. Warda, Sunny Sharma, K. Entian, D. Lafontaine, M. Bohnsack   +5 more
semanticscholar   +1 more source

Traffic of interacting ribosomes: effects of single-machine mechano-chemistry on protein synthesis [PDF]

Physical Review E 75, 021902 (2007), 2006
Many ribosomes simultaneously move on the same messenger RNA (mRNA), each separately synthesizing the protein coded by the mRNA. Earlier models of ribosome traffic represent each ribosome by a ``self-propelled particle'' and capture the dynamics by an extension of the totally asymmetric simple exclusion process (TASEP).
arxiv   +2 more sources

The Ccr4-Not complex monitors the translating ribosome for codon optimality

Science, 2019
Coupling translation and mRNA decay Gene expression requires messenger RNAs (mRNAs)—DNA-derived blueprints of genes—to be translated by protein-producing ribosomes. The levels of mRNAs are tightly regulated, in part by controlling their half-lives.
R. Buschauer, Y. Matsuo, Takato Sugiyama, Ying-Hsin Chen, Najwa Alhusaini, Thomas J. Sweet, Ken Ikeuchi, Jingdong Cheng, Yasuko Matsuki, R. Nobuta, Andrea Gilmozzi, O. Berninghausen, P. Tesina, T. Becker, Jeff Coller, T. Inada, R. Beckmann   +16 more
semanticscholar   +1 more source

Homeostatic Roles of the Proteostasis Network in Dendrites

Frontiers in Cellular Neuroscience, 2020
Cellular protein homeostasis, or proteostasis, is indispensable to the survival and function of all cells. Distinct from other cell types, neurons are long-lived, exhibiting architecturally complex and diverse multipolar projection morphologies that can ...
Erin N. Lottes, Daniel N. Cox
doaj   +1 more source

Protein folding on the ribosome studied using NMR spectroscopy [PDF]

, 2013
NMR spectroscopy is a powerful tool for the investigation of protein folding and misfolding, providing a characterization of molecular structure, dynamics and exchange processes, across a very wide range of timescales and with near atomic resolution.
Agrawal, Agrawal, Amero, Anfinsen, Augustyniak, Augustyniak, Balbach, Ban, Baram, Bhushan, Bhushan, Bhushan, Blanco, Bocharov, Bouvignies, Buevich, Bushuev, Cabrita, Cabrita, Cai, Callaghan, Cavagnero, Cavalli, Chiti, Chow, Christodoulou, Christopher A. Waudby, Clark, Clark, Corazza, Cowgill, Crooke, De Prat Gay, De Prat Gay, de Swiet, Dempsey, Deuerling, Diaconu, Didenko, Dinner, Dobson, Dobson, Dror, Eichmann, Elcock, Eletsky, Ellis, Englander, Ernst, Evans, Farjon, Favier, Fedorov, Fedorov, Fedyukina, Fedyunin, Ferbitz, Ferrage, Fersht, Fersht, Fersht, Fucini, Fucini, Gabashvili, Genevaux, Gershenson, Gilbert, Go, Gudkov, Guo, Han, Hautbergue, Helgstrand, Hiller, Hoch, Hoffmann, Hoffmann, Hoffmann, Hsu, Hsu, Hsu, Hsu, Hyberts, Hyberts, Hyberts, Hyeon, Hélène Launay, Ito, Jansens, John Christodoulou, Kaiser, Kaiser, Katranidis, Kelkar, Kelly, Khushoo, Kimchi-Sarfaty, Kleizen, Klepeis, Komar, Koppel, Korzhnev, Kovacs, Kramer, Kumar, Lakshmipathy, Lavalette, Lescop, Lescop, Levinthal, Li, Li, Lill, Lindorff-Larsen, Lisa D. Cabrita, Loksztejn, Lu, Lucas, Ludlam, Maier, Maldonado, Mallam, Mallam, Martinez-Hackert, Martínez, Matsuura, McCoy, Montesano-Roditis, Mulder, Nakatogawa, Neira, Neira, Neudecker, Neudecker, Nicola, Nissen, Ollerenshaw, Olson, O’Brien, O’Brien, O’Brien, Patzelt, Pervushin, Pervushin, Pervushin, Piana, Potestio, Prentiss, Price, Price, Rajagopalan, Rajagopalan, Raman, Rennella, Riek, Riek, Riek, Robosky, Robustelli, Rovnyak, Rovnyak, Ruschak, Rutkowska, Rutkowska, Salvatella, Schaffitzel, Schanda, Schanda, Schanda, Schmeing, Scholz, Schuwirth, Seidelt, Selenko, Selmer, Serber, Shaw, Shen, Shen, Shimizu, Sprangers, Stejskal, Sułkowska, Tenson, Teter, Theillet, Tritton, Tsalkova, Tugarinov, Ulrich, Vallurupalli, Vendruscolo, Verdier, Virnau, Voehler, Vogtherr, Voss, Waudby, Waudby, Whitford, Wilkins, Wilson, Woolhead, Yao, Zhang, Zhang   +205 more
core   +1 more source

Nascent Ribosomes [PDF]

Cell, 2001
The conversion of a ribosomal RNA transcript to a cytoplasmic ribosome requires hundreds of accessory RNA and protein factors. Two papers published recently in Molecular Cell provide first looks at the association of these processing factors with the intermediates in ribosome synthesis (Harnpicharnchai et al., 2001; Bassler et al., 2001).
openaire   +2 more sources

How Ricin Damages the Ribosome

Toxins, 2019
Ricin belongs to the group of ribosome-inactivating proteins (RIPs), i.e., toxins that have evolved to provide particular species with an advantage over other competitors in nature.
Przemysław Grela, Monika Szajwaj, Patrycja Horbowicz-Drożdżal, Marek Tchórzewski   +3 more
doaj   +1 more source

The Organizing Principles of Eukaryotic Ribosome Recruitment.

Annual Review of Biochemistry, 2019
The stage at which ribosomes are recruited to messenger RNAs (mRNAs) is an elaborate and highly regulated phase of protein synthesis. Upon completion of this step, a ribosome is positioned at an appropriate initiation codon and primed to synthesize the ...
J. Pelletier, N. Sonenberg
semanticscholar   +1 more source

Microtubule-dependent ribosome localization in C. elegans neurons. [PDF]

, 2017
Subcellular localization of ribosomes defines the location and capacity for protein synthesis. Methods for in vivo visualizing ribosomes in multicellular organisms are desirable in mechanistic investigations of the cell biology of ribosome dynamics. Here,
Ellisman, Mark H, Goncharov, Alexandr, Jin, Yishi, Noma, Kentaro   +3 more
core   +1 more source

Viral and cellular translation during SARS‐CoV‐2 infection

FEBS Open Bio, 2022
SARS‐CoV‐2 is a betacoronavirus that emerged in China in December 2019 and which is the causative agent of the Covid‐19 pandemic. This enveloped virus contains a large positive‐sense single‐stranded RNA genome.
Gilbert Eriani, Franck Martin
doaj   +1 more source