Results 71 to 80 of about 237,830 (385)
Viral and cellular translation during SARS‐CoV‐2 infection
FEBS Open Bio, 2022 SARS‐CoV‐2 is a betacoronavirus that emerged in China in December 2019 and which is the causative agent of the Covid‐19 pandemic. This enveloped virus contains a large positive‐sense single‐stranded RNA genome.
Gilbert Eriani, Franck Martin
doaj +1 more source
NUFIP1 is a ribosome receptor for starvation-induced ribophagy
Science, 2018 A selective autophagy receptor identified Autophagosomes engulf and degrade cellular components in lysosomes. Degradation of ribosomes is called ribophagy and is an important source of nutrients.
Gregory A. Wyant +9 more
semanticscholar +1 more source
snoRNPs: Functions in Ribosome Biogenesis
Biomolecules, 2020 Ribosomes are perhaps the most critical macromolecular machine as they are tasked with carrying out protein synthesis in cells. They are incredibly complex structures composed of protein components and heavily chemically modified RNAs.
Sandeep Ojha +2 more
semanticscholar +1 more source
eLife, 2021 Human mitochondria express a genome that encodes thirteen core subunits of the oxidative phosphorylation system (OXPHOS). These proteins insert into the inner membrane co-translationally. Therefore, mitochondrial ribosomes engage with the OXA1L-insertase
Sven Dennerlein +12 more
doaj +1 more source
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, EarlyView.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
eLife, 2019 In eukaryotes, ribosome profiling provides insight into the mechanism of protein synthesis at the codon level. In bacteria, however, the method has been more problematic and no consensus has emerged for how to best prepare profiling samples.
Fuad Mohammad +2 more
semanticscholar +1 more source
On the Ribosomal Density that Maximizes Protein Translation Rate [PDF]
, 2016 During mRNA translation, several ribosomes attach to the same mRNA molecule simultaneously translating it into a protein. This pipelining increases the protein production rate. A natural and important question is what ribosomal density maximizes the protein production rate.
arxiv +1 more source
Ribosome recycling, diffusion, and mRNA loop formation in translational regulation [PDF]
Biophysical Journal, 85, 755-773, (2003), 2003 We explore and quantify the physical and biochemical mechanisms that may be relevant in the regulation of translation. After elongation and detachment from the 3' termination site of mRNA, parts of the ribosome machinery can diffuse back to the initiation site, especially if it is held nearby, enhancing overall translation rates.
arxiv +1 more source
FEBS Letters, EarlyView.LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra +7 more
wiley +1 more source
Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease
Nature Communications, 2019 Ribosome biogenesis is a canonical hallmark of cell growth and proliferation. Here we show that execution of Epithelial-to-Mesenchymal Transition (EMT), a migratory cellular program associated with development and tumor metastasis, is fueled by ...
V. Prakash +27 more
semanticscholar +1 more source