Results 71 to 80 of about 406,930 (327)

The mechanism of error induction by the antibiotic viomycin provides insight into the fidelity mechanism of translation

eLife, 2019
Applying pre-steady state kinetics to an Escherichia-coli-based reconstituted translation system, we have studied how the antibiotic viomycin affects the accuracy of genetic code reading.
Mikael Holm, Chandra Sekhar Mandava, Måns Ehrenberg, Suparna Sanyal   +3 more
doaj   +1 more source

Finding sense in the context

eLife, 2020
Ribosomal profiling has shed new light on how ribosomes can ignore stop codons in messenger RNA.
Kim M Keeling, David M Bedwell
doaj   +1 more source

Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance.

Nature Chemical Biology, 2020
Many antibiotics inhibit bacterial growth by binding to the ribosome and interfering with protein biosynthesis. Macrolides represent one of the most successful classes of ribosome-targeting antibiotics.
M. Svetlov, E. A. Syroegin, E. Aleksandrova, G. Atkinson, S. T. Gregory, A. Mankin, Y. Polikanov   +6 more
semanticscholar   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Mutational analysis of ribosomal proteins in a cohort of pediatric patients with T-cell acute lymphoblastic leukemia reveals Q123R, a novel mutation in RPL10

Frontiers in Genetics, 2022
T-cell acute lymphoblastic leukemia (T-ALL) is a subtype of ALL involving the malignant expansion of T-cell progenitors. It is driven by a number of different possible genetic lesions, including mutations in genes encoding for ribosomal proteins (RPs ...
Lorenza Bacci, Lorenza Bacci, Valentina Indio, Guglielmo Rambaldelli, Cristina Bugarin, Franco Magliocchetti, Franco Magliocchetti, Alberto Del Rio, Alberto Del Rio, Daniela Pollutri, Daniela Pollutri, Fraia Melchionda, Andrea Pession, Marina Lanciotti, Carlo Dufour, Giuseppe Gaipa, Lorenzo Montanaro, Lorenzo Montanaro, Marianna Penzo, Marianna Penzo   +19 more
doaj   +1 more source

Thermodynamic and kinetic insights into stop codon recognition by release factor 1. [PDF]

, 2014
Stop codon recognition is a crucial event during translation termination and is performed by class I release factors (RF1 and RF2 in bacterial cells). Recent crystal structures showed that stop codon recognition is achieved mainly through a network of ...
Joseph, Simpson, Mathew, Merrill A, Trappl, Krista   +2 more
core  

Molecular Simulations of the Ribosome and Associated Translation Factors

, 2014
The ribosome is a macromolecular complex which is responsible for protein synthesis in all living cells according to their transcribed genetic information.
Hamed H. Alsulami (532535), Muhammad Bilal Ashraf (532534), Muhammad Shahab Alhuthali (532536), Tasawar Hayat (433317)   +3 more
core   +6 more sources

Global analysis of gene expression reveals mRNA superinduction is required for the inducible immune response to a bacterial pathogen. [PDF]

, 2017
The inducible innate immune response to infection requires a concerted process of gene expression that is regulated at multiple levels. Most global analyses of the innate immune response have focused on transcription induced by defined immunostimulatory ...
Barry, Kevin C, Ingolia, Nicholas T, Vance, Russell E   +2 more
core   +3 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Optimal localization patterns in bacterial protein synthesis

, 2018
In $\textit{Escherichia coli}$ bacterium, the molecular compounds involved in protein synthesis, messenger RNAs (mRNAs) and ribosomes, show marked intracellular localization patterns.
Castellana, Michele, Nguyen, Jacky
core   +1 more source