Special issue: Ribosome-inactivating proteins : commemorative issue in honor of Professor Fiorenzo Stirpe [PDF]
, 2017 The family of ribosome-inactivating proteins (RIPs) groups all enzymes (EC.3.2.2.22) with a so-called RIP domain which comprises N-glycosidase activity and enables these proteins to catalytically inactivate ribosomes.[...
Van Damme, Els
core +3 more sources
Clustered bottlenecks in mRNA translation and protein synthesis
, 2003 We construct an algorithm that generates large, band-diagonal transition matrices for a totally asymmetric exclusion process (TASEP) with local hopping rate inhomogeneities.
B. Alberts +12 more
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Discrete nascent chain lengths are required for the insertion of presecretory proteins into microsomal membranes. [PDF]
, 1993 Ribosomes synthesizing nascent secretory proteins are targeted to the membrane by the signal recognition particle (SRP), a small ribonucleoprotein that binds to the signal peptide as it emerges from the ribosome.
Walter, P, Wolin, SL
core
Toxins, 2011 Fungal toxins, such as those produced by members of the order Hypocreales, have widespread effects on cereal crops, resulting in yield losses and the potential for severe disease and mortality in humans and livestock.
Barbara A. Blackwell +4 more
doaj +1 more source
Molecular interactions between the constituents of small ribosomal subunit [PDF]
arXiv, 2012 Availability of high-resolution crystal structures of ribosomal subunits of different species opens a route to investigate about molecular interactions between its constituents and stabilization strategy. Structural analysis of the small ribosomal subunit shows that primary binder proteins are mainly employed in stabilizing the folded ribosomal RNA by ...
arxiv
Translatome and Transcriptome Profiling of Hypoxic-Induced Rat Cardiomyocytes
Molecular Therapy: Nucleic Acids, 2020 Adult cardiac hypoxia as a crucial pathogenesis factor can induce detrimental effects on cardiac injury and dysfunction. The global transcriptome and translatome reflecting the cellular response to hypoxia have not yet been extensively studied in ...
Zhijie Shen, Lixiong Zeng, Zhihui Zhang
doaj
Biotechnology Journal, 2012 AbstractSee accompanying article by Contreras‐Martin et al.
openaire +3 more sources
Extensive evolution of cereal ribosome-inactivating proteins translates into unique structural features, activation mechanisms, and physiological roles [PDF]
, 2017 Ribosome-inactivating proteins (RIPs) are a class of cytotoxic enzymes that can depurinate rRNAs thereby inhibiting protein translation. Although these proteins have also been detected in bacteria, fungi, and even some insects, they are especially ...
De Zaeytijd, Jeroen, Van Damme, Els
core +2 more sources
Alkylative damage of mRNA leads to ribosome stalling and rescue by trans translation in bacteria
eLife, 2020 Similar to DNA replication, translation of the genetic code by the ribosome is hypothesized to be exceptionally sensitive to small chemical changes to its template mRNA.
Erica N Thomas +4 more
doaj +1 more source
Transcription-translation coupling: direct interactions of RNA polymerase with ribosomes and ribosomal subunits. [PDF]
, 2017 In prokaryotes, RNA polymerase and ribosomes can bind concurrently to the same RNA transcript, leading to the functional coupling of transcription and translation.
Blaha, Gregor M +9 more
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