Results 81 to 90 of about 358,575 (311)

Aging in Rats Differentially Affects Markers of Transcriptional and Translational Capacity in Soleus and Plantaris Muscle

Frontiers in Physiology, 2017
Alterations in transcriptional and translational mechanisms occur during skeletal muscle aging and such changes may contribute to age-related atrophy. Herein, we examined markers related to global transcriptional output (i.e., myonuclear number, total ...
Christopher B. Mobley, Petey W. Mumford, Wesley C. Kephart, Cody T. Haun, Angelia M. Holland, Darren T. Beck, Darren T. Beck, Jeffrey S. Martin, Jeffrey S. Martin, Kaelin C. Young, Kaelin C. Young, Richard G. Anderson, Romil K. Patel, Gillis L. Langston, Ryan P. Lowery, Ryan P. Lowery, Jacob M. Wilson, Michael D. Roberts, Michael D. Roberts   +18 more
doaj   +1 more source

Translation inhibitory elements from Hoxa3 and Hoxa11 mRNAs use uORFs for translation inhibition

eLife, 2021
During embryogenesis, Hox mRNA translation is tightly regulated by a sophisticated molecular mechanism that combines two RNA regulons located in their 5’UTR. First, an internal ribosome entry site (IRES) enables cap-independent translation.
Fatima Alghoul, Schaeffer Laure, Gilbert Eriani, Franck Martin   +3 more
doaj   +1 more source

Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design.

Annual Review of Biochemistry, 2018
Genetic information is translated into proteins by the ribosome. Structural studies of the ribosome and of its complexes with factors and inhibitors have provided invaluable information on the mechanism of protein synthesis. Ribosome inhibitors are among
Jinzhong Lin, Dejian Zhou, T. Steitz, Y. Polikanov, M. Gagnon   +4 more
semanticscholar   +1 more source

The Prospects for Immigration Amendments [PDF]

, 1956
Obg proteins are a family of P-loop GTPases, conserved from bacteria to human. The Obg protein in Escherichia coli (ObgE) has been implicated in many diverse cellular functions, with proposed molecular roles in two global processes, ribosome assembly and
Cao, Wei, Feng, Boya, Gao, Ning, Guo, Qiang, Lei, Jianlin, Li, Ningning, Mandava, Chandra Sekhar, Sanyal, Suparna, Wang, Jie, Wang, Zhixin, Wu, Jiawei, Zhang, Yanqing, Zhang, Yixiao   +12 more
core   +4 more sources

Genome-wide Survey of Ribosome Collision

Cell Reports, 2020
Summary: Ribosome movement is not always smooth and is rather often impeded. For ribosome pauses, fundamental issues remain to be addressed, including where ribosomes pause on mRNAs, what kind of RNA/amino acid sequence causes this pause, and the ...
Peixun Han, Yuichi Shichino, Tilman Schneider-Poetsch, Mari Mito, Satoshi Hashimoto, Tsuyoshi Udagawa, Kenji Kohno, Minoru Yoshida, Yuichiro Mishima, Toshifumi Inada, Shintaro Iwasaki   +10 more
doaj  

Exploring Wells-Dawson Clusters Associated With the Small Ribosomal Subunit

Frontiers in Chemistry, 2019
The polyoxometalate P2W18O626-, the Wells-Dawson cluster, stabilized the ribosome sufficiently for the crystallographers to solve the phase problem and improve the structural resolution.
Debbie C. Crans, Irma Sánchez-Lombardo, Irma Sánchez-Lombardo, Craig C. McLauchlan   +3 more
doaj   +1 more source

Functional Analysis of PSRP1, the Chloroplast Homolog of a Cyanobacterial Ribosome Hibernation Factor

Plants, 2020
Bacterial ribosome hibernation factors sequester ribosomes in an inactive state during the stationary phase and in response to stress. The cyanobacterial ribosome hibernation factor LrtA has been suggested to inactivate ribosomes in the dark and to be ...
Kevin Swift, Prakitchai Chotewutmontri, Susan Belcher, Rosalind Williams-Carrier, Alice Barkan   +4 more
doaj   +1 more source

A systematically-revised ribosome profiling method for bacteria reveals pauses at single-codon resolution

eLife, 2019
In eukaryotes, ribosome profiling provides insight into the mechanism of protein synthesis at the codon level. In bacteria, however, the method has been more problematic and no consensus has emerged for how to best prepare profiling samples.
Fuad Mohammad, R. Green, Allen R. Buskirk   +2 more
semanticscholar   +1 more source

Knock-Down of a Novel snoRNA in Tetrahymena Reveals a Dual Role in 5.8S rRNA Processing and Generation of a 26S rRNA Fragment

Biomolecules, 2018
In eukaryotes, 18S, 5.8S, and 28S rRNAs are transcribed as precursor molecules that undergo extensive modification and nucleolytic processing to form the mature rRNA species. Central in the process are the small nucleolar RNAs (snoRNAs).
Kasper L. Andersen, Henrik Nielsen
doaj   +1 more source

A nascent polypeptide sequence modulates DnaA translation elongation in response to nutrient availability

eLife, 2021
The ability to regulate DNA replication initiation in response to changing nutrient conditions is an important feature of most cell types. In bacteria, DNA replication is triggered by the initiator protein DnaA, which has long been suggested to respond ...
Michele Felletti, Cédric Romilly, E Gerhart H Wagner, Kristina Jonas   +3 more
doaj   +1 more source