Results 1 to 10 of about 173,360 (283)

Autonomous ribosome biogenesis in vitro [PDF]

Nature Communications
Ribosome biogenesis is pivotal in the self-replication of life. In Escherichia coli, three ribosomal RNAs and 54 ribosomal proteins are synthesized and subjected to cooperative hierarchical assembly facilitated by numerous accessory factors.
Yuishin Kosaka, Yumi Miyawaki, Megumi Mori, Shunsuke Aburaya, Chisato Nishizawa, Takeshi Chujo, Tatsuya Niwa, Takumi Miyazaki, Takashi Sugita, Mao Fukuyama, Hideki Taguchi, Kazuhito Tomizawa, Kenji Sugase, Mitsuyoshi Ueda, Wataru Aoki   +14 more
doaj   +3 more sources

Ribosome biogenesis in disease: new players and therapeutic targets

Signal Transduction and Targeted Therapy, 2023
The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome biogenesis is the process that generates ribosomes and plays an essential role in cell proliferation, differentiation, apoptosis, development, and transformation. The mTORC1,
Lijuan Jiao, Yuzhe Liu, Xi-Yong Yu, Xiangbin Pan, Yu Zhang, Junchu Tu, Yao-Hua Song, Yangxin Li   +7 more
doaj   +2 more sources

Low level of Fibrillarin, a ribosome biogenesis factor, is a new independent marker of poor outcome in breast cancer

BMC Cancer, 2022
Background A current critical need remains in the identification of prognostic and predictive markers in early breast cancer. It appears that a distinctive trait of cancer cells is their addiction to hyperactivation of ribosome biogenesis. Thus, ribosome
Flora Nguyen Van Long, Audrey Lardy-Cleaud, Dimitri Carène, Caroline Rossoni, Frédéric Catez, Paul Rollet, Nathalie Pion, Déborah Monchiet, Agathe Dolbeau, Marjorie Martin, Valentin Simioni, Susan Bray, Doris Le Beherec, Fernanda Mosele, Ibrahim Bouakka, Amélie Colombe-Vermorel, Laetitia Odeyer, Alexandra Diot, Lee B. Jordan, Alastair M. Thompson, Françoise Jamen, Thierry Dubois, Sylvie Chabaud, Stefan Michiels, Isabelle Treilleux, Jean-Christophe Bourdon, David Pérol, Alain Puisieux, Fabrice André, Jean-Jacques Diaz, Virginie Marcel   +30 more
doaj   +2 more sources

Dyskerin: an essential pseudouridine synthase with multifaceted roles in ribosome biogenesis, splicing, and telomere maintenance [PDF]

RNA: A publication of the RNA Society, 2021
Dyskerin and its homologs are ancient and conserved enzymes that catalyze the most common post-transcriptional modification found in cells, pseudouridylation.
Alexandre Garus, Chantal Autexier
openalex   +2 more sources

Tracing Eukaryotic Ribosome Biogenesis Factors Into the Archaeal Domain Sheds Light on the Evolution of Functional Complexity

Frontiers in Microbiology, 2021
Ribosome assembly is an essential and carefully choreographed cellular process. In eukaryotes, several 100 proteins, distributed across the nucleolus, nucleus, and cytoplasm, co-ordinate the step-wise assembly of four ribosomal RNAs (rRNAs) and ...
Mehmet Birikmen, Katherine E. Bohnsack, Vinh Tran, Sharvari Somayaji, Markus T. Bohnsack, Markus T. Bohnsack, Ingo Ebersberger, Ingo Ebersberger, Ingo Ebersberger   +8 more
doaj   +2 more sources

Ribosome biogenesis: A central player in liver diseases [PDF]

Genes and Diseases
Ribosome biogenesis is a multi-step process that initiates within the nucleolus, terminates in the cytoplasm, and determines the rate of protein synthesis. Ribosome biogenesis is essential for maintaining liver function.
Wei Luo, Jing Zhou, Yongmin Yan, Xuezhong Xu   +3 more
doaj   +2 more sources

Ribosome Biogenesis Alterations in Colorectal Cancer

Cells, 2020
Many studies have focused on understanding the regulation and functions of aberrant protein synthesis in colorectal cancer (CRC), leaving the ribosome, its main effector, relatively underappreciated in CRC.
Sophie Nait Slimane, Virginie Marcel, Tanguy Fenouil, Frédéric Catez, Jean-Christophe Saurin, Philippe Bouvet, Jean-Jacques Diaz, Hichem C. Mertani   +7 more
doaj   +2 more sources

The Ribosome Biogenesis—Cancer Connection

Cells, 2019
Multifaceted relations link ribosome biogenesis to cancer. Ribosome biogenesis takes place in the nucleolus. Clarifying the mechanisms involved in this nucleolar function and its relationship with cell proliferation: 1) allowed the understanding of the ...
Marianna Penzo, Lorenzo Montanaro, Davide Treré, Massimo Derenzini   +3 more
doaj   +2 more sources

Targeting interferon-stimulated gene of 20 kDa protein (Isg20) inhibits ribosome biogenesis to ameliorate the progression of renal fibrosis. [PDF]

PLoS ONE
Chronic kidney disease (CKD) is a global health issue that significantly threatens human health, with its incidence increasing annually. Renal fibrosis is characterized by the progressive loss of kidney function, leading to significant morbidity and ...
Xiaoming Liu, Huijuan Wang, Kai Wang, Ying Liu   +3 more
doaj   +2 more sources

Ribosome Biogenesis in Archaea

Frontiers in Microbiology, 2021
Making ribosomes is a major cellular process essential for the maintenance of functional ribosome homeostasis and to ensure appropriate gene expression.
Paola Londei, Sébastien Ferreira-Cerca
doaj   +2 more sources