Results 1 to 10 of about 190,238 (358)

Low level of Fibrillarin, a ribosome biogenesis factor, is a new independent marker of poor outcome in breast cancer [PDF]

BMC Cancer, 2022
Background A current critical need remains in the identification of prognostic and predictive markers in early breast cancer. It appears that a distinctive trait of cancer cells is their addiction to hyperactivation of ribosome biogenesis. Thus, ribosome
Flora Nguyen Van Long, Audrey Lardy-Cleaud, Dimitri Carène, Caroline Rossoni, Frédéric Catez, Paul Rollet, Nathalie Pion, Déborah Monchiet, Agathe Dolbeau, Marjorie Martin, Valentin Simioni, Susan Bray, Doris Le Beherec, Fernanda Mosele, Ibrahim Bouakka, Amélie Colombe-Vermorel, Laetitia Odeyer, Alexandra Diot, Lee B. Jordan, Alastair M. Thompson, Françoise Jamen, Thierry Dubois, Sylvie Chabaud, Stefan Michiels, Isabelle Treilleux, Jean-Christophe Bourdon, David Pérol, Alain Puisieux, Fabrice André, Jean-Jacques Diaz, Virginie Marcel   +30 more
doaj   +4 more sources

The impact of ribosome biogenesis in cancer: from proliferation to metastasis. [PDF]

NAR Cancer
The dysregulation of ribosome biogenesis is a hallmark of cancer, facilitating the adaptation to altered translational demands essential for various aspects of tumor progression.
Hwang SP, Denicourt C.
europepmc   +4 more sources

Characterization of nucleolar SUMO isopeptidases unveils a general p53-independent checkpoint of impaired ribosome biogenesis [PDF]

Nature Communications, 2023
Ribosome biogenesis is a multi-step process, in which a network of trans-acting factors ensures the coordinated assembly of pre-ribosomal particles in order to generate functional ribosomes.
Judith Dönig, Hannah Mende, Jimena Davila Gallesio, Kristina Wagner, Paul Hotz, Kathrin Schunck, Tanja Piller, Soraya Hölper, Sara Uhan, Manuel Kaulich, Matthias Wirth, Ulrich Keller, Georg Tascher, Katherine E. Bohnsack, Stefan Müller   +14 more
doaj   +4 more sources

Autonomous ribosome biogenesis in vitro [PDF]

Nature Communications
Ribosome biogenesis is pivotal in the self-replication of life. In Escherichia coli, three ribosomal RNAs and 54 ribosomal proteins are synthesized and subjected to cooperative hierarchical assembly facilitated by numerous accessory factors.
Yuishin Kosaka, Yumi Miyawaki, Megumi Mori, Shunsuke Aburaya, Chisato Nishizawa, Takeshi Chujo, Tatsuya Niwa, Takumi Miyazaki, Takashi Sugita, Mao Fukuyama, Hideki Taguchi, Kazuhito Tomizawa, Kenji Sugase, Mitsuyoshi Ueda, Wataru Aoki   +14 more
doaj   +3 more sources

Ribosome biogenesis and ribosome therapy in cancer cells [PDF]

Research Results in Pharmacology, 2022
Introduction: The process of protein synthesis is a vital process for all kingdoms of life. The ribosome is a ribonucleoprotein complex that reads the genetic code, from messenger RNA (mRNA) to produce proteins and to tightly regulate and ensure cells ...
Gazmend Temaj, Rifat Hadziselimovic, Hilada Nefic, Nexhibe Nuhii   +3 more
doaj   +5 more sources

Identification of ribosome biogenesis genes and subgroups in ischaemic stroke [PDF]

Frontiers in Immunology
BackgroundIschaemic stroke is a leading cause of death and severe disability worldwide. Given the importance of protein synthesis in the inflammatory response and neuronal repair and regeneration after stroke, and that proteins are acquired by ribosomal ...
Xi Wang, Xiao-Yu Zhang, Nan-Qing Liao, Ze-Hua He, Qing-Feng Chen   +4 more
doaj   +2 more sources

The ribosome biogenesis factor Nol11 is required for optimal rDNA transcription and craniofacial development in Xenopus. [PDF]

PLoS Genetics, 2015
The production of ribosomes is ubiquitous and fundamental to life. As such, it is surprising that defects in ribosome biogenesis underlie a growing number of symptomatically distinct inherited disorders, collectively called ribosomopathies. We previously
John N Griffin, Samuel B Sondalle, Florencia Del Viso, Susan J Baserga, Mustafa K Khokha   +4 more
doaj   +6 more sources

WDR68 stimulates cellular proliferation via activating ribosome biogenesis in 293T cells [PDF]

Neoplasia: An International Journal for Oncology Research
WDR68, a conserved WD40 repeat-containing protein, interacts with E1A and is involved in the E1A-induced cell proliferation and oncogenic transformation, but the intrinsic molecular mechanisms of this process remain to be elucidated. Here, we demonstrate
Zhaoxia Wu, Lanfeng Xie, Ping Yuan, Yimin Chu, Haixia Peng   +4 more
doaj   +2 more sources

The cytidine deaminase APOBEC3A regulates nucleolar function to promote cell growth and ribosome biogenesis. [PDF]

PLoS Biology
Cancer initiates as a consequence of genomic mutations and its subsequent progression relies in part on increased production of ribosomes to maintain high levels of protein synthesis for unchecked cell growth.
Mason A McCool, Carson J Bryant, Laura Abriola, Yulia V Surovtseva, Susan J Baserga   +4 more
doaj   +2 more sources

circUBR5 promotes ribosome biogenesis and induces docetaxel resistance in triple-negative breast cancer cell lines via the miR-340-5p/CMTM6/c-MYC axis [PDF]

Neoplasia: An International Journal for Oncology Research
Objective: Docetaxel (DTX) represents an effective chemotherapeutic agent for treating triple-negative breast cancer (TNBC), but the efficacy is strongly limited by drug resistance.
Xuedong Wang, Xinping Wang, Juan Gu, Yilei Wei, Yueping Wang   +4 more
doaj   +2 more sources