Ribosome biogenesis: A central player in liver diseases [PDF]
Genes and DiseasesRibosome biogenesis is a multi-step process that initiates within the nucleolus, terminates in the cytoplasm, and determines the rate of protein synthesis. Ribosome biogenesis is essential for maintaining liver function.
Wei Luo +3 more
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Elucidating AML ribosome biogenesis reshaping prognostic assessment and immune microenvironment integrated single-cell and bulk RNA analysis [PDF]
Frontiers in ImmunologyBackgroundAcute Myeloid Leukemia (AML) is an aggressive hematologic malignancy with significant clinical challenges due to its heterogeneity and high relapse rate.
Xiaohe Chen +4 more
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Targeting interferon-stimulated gene of 20 kDa protein (Isg20) inhibits ribosome biogenesis to ameliorate the progression of renal fibrosis. [PDF]
PLoS ONEChronic kidney disease (CKD) is a global health issue that significantly threatens human health, with its incidence increasing annually. Renal fibrosis is characterized by the progressive loss of kidney function, leading to significant morbidity and ...
Xiaoming Liu +3 more
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Autonomous ribosome biogenesis in vitro [PDF]
Nature CommunicationsRibosome biogenesis is pivotal in the self-replication of life. In Escherichia coli, three ribosomal RNAs and 54 ribosomal proteins are synthesized and subjected to cooperative hierarchical assembly facilitated by numerous accessory factors.
Yuishin Kosaka +14 more
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Prognostic model identification of ribosome biogenesis-related genes in pancreatic cancer based on multiple machine learning analyses [PDF]
Discover OncologyBackground Pancreatic cancer is a highly aggressive cancer characterized by low survival rate. Enhanced ribosome biogenesis may be associated with tumor drug resistance and malignant phenotypes, representing a potential therapeutic target in pancreatic ...
Yuan Sun +4 more
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Identification of ribosome biogenesis genes and subgroups in ischaemic stroke [PDF]
Frontiers in ImmunologyBackgroundIschaemic stroke is a leading cause of death and severe disability worldwide. Given the importance of protein synthesis in the inflammatory response and neuronal repair and regeneration after stroke, and that proteins are acquired by ribosomal ...
Xi Wang +4 more
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Ribosome biogenesis and ribosome therapy in cancer cells [PDF]
Research Results in Pharmacology, 2022 Introduction: The process of protein synthesis is a vital process for all kingdoms of life. The ribosome is a ribonucleoprotein complex that reads the genetic code, from messenger RNA (mRNA) to produce proteins and to tightly regulate and ensure cells ...
Gazmend Temaj +3 more
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40S ribosome biogenesis co-factors are essential for gametophyte and embryo development [PDF]
, 2013 Ribosome biogenesis is well described in Saccharomyces cerevisiae. In contrast only very little information is available on this pathway in plants. This study presents the characterization of five putative protein co-factors of ribosome biogenesis in ...
Bohnsack, Markus T. +6 more
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PLoS Biology, 2023 Interorgan communication is crucial for multicellular organismal growth, development, and homeostasis. Cell nonautonomous inhibitory cues, which limit tissue-specific growth alterations, are not well characterized due to cell ablation approach ...
Qiuxia Zhao +4 more
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Nature Communications, 2023 Ribosome biogenesis is a multi-step process, in which a network of trans-acting factors ensures the coordinated assembly of pre-ribosomal particles in order to generate functional ribosomes.
Judith Dönig +14 more
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