Results 11 to 20 of about 173,360 (283)

Prognostic model identification of ribosome biogenesis-related genes in pancreatic cancer based on multiple machine learning analyses [PDF]

Discover Oncology
Background Pancreatic cancer is a highly aggressive cancer characterized by low survival rate. Enhanced ribosome biogenesis may be associated with tumor drug resistance and malignant phenotypes, representing a potential therapeutic target in pancreatic ...
Yuan Sun, Yan Li, Anlan Zhang, Tao Hu, Ming Li   +4 more
doaj   +2 more sources

Identification of ribosome biogenesis genes and subgroups in ischaemic stroke [PDF]

Frontiers in Immunology
BackgroundIschaemic stroke is a leading cause of death and severe disability worldwide. Given the importance of protein synthesis in the inflammatory response and neuronal repair and regeneration after stroke, and that proteins are acquired by ribosomal ...
Xi Wang, Xiao-Yu Zhang, Nan-Qing Liao, Ze-Hua He, Qing-Feng Chen   +4 more
doaj   +2 more sources

Ribosome biogenesis and ribosome therapy in cancer cells [PDF]

Research Results in Pharmacology, 2022
Introduction: The process of protein synthesis is a vital process for all kingdoms of life. The ribosome is a ribonucleoprotein complex that reads the genetic code, from messenger RNA (mRNA) to produce proteins and to tightly regulate and ensure cells ...
Gazmend Temaj, Rifat Hadziselimovic, Hilada Nefic, Nexhibe Nuhii   +3 more
doaj   +3 more sources

Ribosome biogenesis factors—from names to functions

EMBO Journal, 2023
The assembly of ribosomal subunits is a highly orchestrated process that involves a huge cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified by genetic screens and proteomic approaches of pre‐ribosomal particles
Kerstin Dörner, C. Ruggeri, I. Zemp, U. Kutay   +3 more
semanticscholar   +1 more source

Ribosome biogenesis and function in development and disease.

Development, 2023
Although differential transcription drives the development of multicellular organisms, the ultimate readout of a protein-coding gene is ribosome-dependent mRNA translation.
Chunyang Ni, M. Buszczak
semanticscholar   +1 more source

Inhibition of ribosome biogenesis in the epidermis is sufficient to trigger organism-wide growth quiescence independently of nutritional status in C. elegans.

PLoS Biology, 2023
Interorgan communication is crucial for multicellular organismal growth, development, and homeostasis. Cell nonautonomous inhibitory cues, which limit tissue-specific growth alterations, are not well characterized due to cell ablation approach ...
Qiuxia Zhao, Rekha Rangan, Shinuo Weng, Cem Özdemir, Elif Sarinay Cenik   +4 more
doaj   +1 more source

KMT2D Deficiency Promotes Myeloid Leukemias which Is Vulnerable to Ribosome Biogenesis Inhibition

Advancement of science, 2023
KMT2C and KMT2D are the most frequently mutated epigenetic genes in human cancers. While KMT2C is identified as a tumor suppressor in acute myeloid leukemia (AML), the role of KMT2D remains unclear in this disease, though its loss promotes B cell ...
Jing Xu, Ailing Zhong, S. Zhang, Mei Chen, Lanxin Zhang, X. Hang, Jianan Zheng, Baohong Wu, Xin-Jie Deng, Xiangyu Pan, Zhongwang Wang, Lu Qi, Kaidou Shi, Shujun Li, Yiyun Wang, Manli Wang, Xuelan Chen, Qi Zhang, Peng Liu, R. Gale, C. Chen, Yu Liu, T. Niu   +22 more
semanticscholar   +1 more source

USP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress

Nature Communications, 2023
Tumor growth requires elevated ribosome biogenesis. Targeting ribosomes is an important strategy for cancer therapy. The ribosome inhibitor, homoharringtonine (HHT), is used for the clinical treatment of leukemia, yet it is ineffective for the treatment ...
Kewei Qin, Shuhan Yu, Yang Liu, Rongtian Guo, Shiya Guo, Junjie Fei, Yuemeng Wang, Kaiyuan Jia, Zhiqiang Xu, Hu Chen, Fengtian Li, Mengmeng Niu, M. Dai, Lunzhi Dai, Yang Cao, Yujun Zhang, Zhixiong Xiao, Yong Yi   +17 more
semanticscholar   +1 more source

Characterization of nucleolar SUMO isopeptidases unveils a general p53-independent checkpoint of impaired ribosome biogenesis

Nature Communications, 2023
Ribosome biogenesis is a multi-step process, in which a network of trans-acting factors ensures the coordinated assembly of pre-ribosomal particles in order to generate functional ribosomes.
Judith Dönig, Hannah Mende, Jimena Davila Gallesio, Kristina Wagner, Paul Hotz, Kathrin Schunck, Tanja Piller, Soraya Hölper, Sara Uhan, Manuel Kaulich, Matthias Wirth, Ulrich Keller, Georg Tascher, Katherine E. Bohnsack, Stefan Müller   +14 more
doaj   +1 more source

Ribosome Biogenesis: A Central Player in Cancer Metastasis and Therapeutic Resistance

Cancer Research, 2022
Ribosomes are a complex ensemble of rRNA and ribosomal proteins that function as mRNA translation machines. Ribosome biogenesis is a multistep process that begins in the nucleolus and concludes in the cytoplasm.
Amr R. Elhamamsy, Brandon J. Metge, H. Alsheikh, L. Shevde, Rajeev S. Samant   +4 more
semanticscholar   +1 more source