Results 201 to 210 of about 173,360 (283)

Risk model of liquid–liquid phase separation‐related genes reveals the prognosis and tumor microenvironment characteristics of colorectal cancer

Journal of Cell Communication and Signaling, Volume 19, Issue 4, December 2025.
A prognostic framework for colorectal cancer based on liquid–liquid phase separation (LLPS) genes stratifies patients by survival and tumor microenvironment. The pivotal gene signature—encompassing ASXL1, DDX21, HNRNPA1L2, TACC3, and TRIM28—is functionally linked to epigenetic and splicing dysregulation, providing independent risk assessment and ...
Hui Liu, Ziwen Chen, Jie Hao, Ziyi Dong, Yaoyang Guo, Minghan Qiu, Xipeng Zhang, Ming Gao, Haiyang Zhang, Mingqing Zhang   +9 more
wiley   +1 more source

PCDHGB7 inhibits the progression of triple-negative breast cancer by suppressing XRCC5/MYC-mediated ribosome biogenesis. [PDF]

Clin Transl Med
Shan M, Bi H, Sun H, Li Y, Li Z, Wang Z, Dong J, Sang S, Ren L, Ye Y, Wang T, Volarević S, Su R, Zhang L, Zhang M, He Y, Zhang G, Li J, Li X.   +18 more
europepmc   +1 more source

Transcriptional Regulation of Microglial Metabolic and Activation States by P2RY12

Glia, Volume 73, Issue 12, Page 2464-2482, December 2025.
Main Points Transcriptionally, P2RY12‐deficient microglia show heightened metabolic activity, iron handling and oxidative stress at baseline. Upon LPS challenge, impaired glutathione antioxidant responses suggest increased vulnerability to ferroptosis. ABSTRACT Microglia are the resident immune cells of the CNS.
Aida Oryza Lopez‐Ortiz, Madison Doceti, JaQuinta Thomas, Abigayle Duffy, Morgan Coburn, Akhabue K. Okojie, Audrey Lee, Elizabeth Aidita Sou, Alban Gaultier, Ukpong B. Eyo   +9 more
wiley   +1 more source

Insights into the Mechanism of Ribosomal Incorporation of Mammalian L13a Protein during Ribosome Biogenesis [PDF]

, 2013
Priyanka Das, Abhijit Basu, Aditi Biswas, Darshana Poddar, Joel Andrews, Sailen Barik, Anton A. Komar, Barsanjit Mazumder   +7 more
openalex   +1 more source

Primary‐Stage Colon Cancer Impairs Muscle Energy Metabolism by Suppressing Mitochondrial Complex I Activity

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Colon cancer (CC), the third most common cancer worldwide, is accompanied by cachexia in 30% of patients. Its associated muscle loss directly impairs therapeutic response and survival. Early intervention is crucial, yet the underlying mechanisms of early‐stage muscle dysfunction remain unclear.
Xiaolin Li, Miranda van der Ende, Hanneke Moonen, Rogier Plas, Susanne Lotstra, Mieke Poland, Jaap Keijer, Renger F. Witkamp, Tjarda van Heek, Sander Grefte, Klaske van Norren, the COMUNEX group, Flip M. Kruyt, Colin Sietses, Gabie M. de Jong, Roland M. H. G. Mollen, Joé L. P. Kolkert, Dik Snijdelaar, Marlieke Visser, Jaap Dronkers   +19 more
wiley   +1 more source

Regulation of SirT1-Nucleomethylin Binding by rRNA Coordinates Ribosome Biogenesis with Nutrient Availability [PDF]

, 2013
Leixiang Yang, Tanjing Song, Lihong Chen, Neha Kabra, Hong Zheng, John M. Koomen, Edward Seto, Jiandong Chen   +7 more
openalex   +1 more source

Small‐Molecule Targeting MuRF1 Protects Against Denervation‐Induced Diaphragmatic Dysfunction: Underlying Molecular Mechanisms

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Mechanical inactivity rapidly induces diaphragm muscle fibres' contractile dysfunction and atrophy. Diaphragm weakness can impair respiratory function, quality of life and increase risks of morbidity and mortality. Muscle RING‐finger protein‐1 (MuRF1) expression is upregulated during denervation and muscle inactivity and is known to
Fernando Ribeiro, Paulo R. Jannig, Siegfried Labeit, Anselmo S. Moriscot   +3 more
wiley   +1 more source

Single-cell multi-omics of ribosome biogenesis-related genes reveals immune microenvironment in psoriasis and constructs a diagnostic model. [PDF]

Clin Exp Med
Xu Y, Liu S.
europepmc   +1 more source

Supplementary Figure 10 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Prahalathan Pichavaram, Carolyn M. Jablonowski, Jie Fang, Andrew M. Fleming, Hyea Jin Gil, Andrew S. Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Christopher L. Morton, Gerard P. Zambetti, Andrew M. Davidoff, Jun Yang, Andrew J. Murphy   +13 more
openalex   +1 more source

Target of rapamycin signaling in pea embryos is dependent on glutamine but detached from seed storage protein biosynthesis

New Phytologist, Volume 248, Issue 6, Page 2833-2849, December 2025.
Summary Target of rapamycin (TOR) kinase is the hub of a eukaryotic master signaling network that integrates nutritional and hormonal signals into cellular activities. Most studies on TOR in plants have focused on seedlings, where TOR is most responsive to light and sucrose.
Brendan M. O'Leary, Suvi Honkanen, Vinti Kumari, Christoph Rampitsch, Eiji Nambara, A. Harvey Millar   +5 more
wiley   +1 more source