Results 21 to 30 of about 173,360 (283)
p53 at the crossroad of DNA replication and ribosome biogenesis stress pathways
Cell Death and Differentiation, 2022 Despite several decades of intense research focused on understanding function(s) and disease-associated malfunction of p53, there is no sign of any “mid-life crisis” in this rapidly advancing area of biomedicine. Firmly established as the hub of cellular
M. Lindström +2 more
semanticscholar +1 more source
bioRxiv, 2022 5-Methylcytosine (m5C) is a base modification broadly found on various RNAs in the human transcriptome. In eukaryotes, m5C is catalyzed by enzymes of the NSUN family composed of seven human members (NSUN1-7).
Han Liao +7 more
semanticscholar +1 more source
Biomedicines, 2022 Ribosome biogenesis is a cellular process critical for protein homeostasis during cell growth and multiplication. Our previous study confirmed up-regulation of ribosome biogenesis during endometriosis progression and malignant transition, thus anti ...
Cherry Yin-Yi Chang +13 more
doaj +1 more source
Targeting Ribosome Biogenesis in Cancer: Lessons Learned and Way Forward
Cancers, 2022 Simple Summary Cells need to produce ribosomes to sustain continuous proliferation and expand in numbers, a feature that is even more prominent in uncontrollably proliferating cancer cells.
A. Zisi, J. Bartek, M. Lindström
semanticscholar +1 more source
Research Progress of Ribosome Biogenesis and Cancer
Zhongliu Fangzhi Yanjiu, 2020 As an important biological process, ribosome biogenesis determines the rate of protein synthesis in cells. However, ribosome biogenesis is abnormally regulated in tumors under strong growth pressure.
QIAN Lili, ZHANG Honghe
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Ribosome Biogenesis and Cancer: Overview on Ribosomal Proteins
International Journal of Molecular Sciences, 2021 Cytosolic ribosomes (cytoribosomes) are macromolecular ribonucleoprotein complexes that are assembled from ribosomal RNA and ribosomal proteins, which are essential for protein biosynthesis.
Annalisa Pecoraro +3 more
semanticscholar +1 more source
RNA folding and functions of RNA helicases in ribosome biogenesis
RNA Biology, 2022 Eukaryotic ribosome biogenesis involves the synthesis of ribosomal RNA (rRNA) and its stepwise folding into the unique structure present in mature ribosomes.
Valentin Mitterer, Brigitte Pertschy
semanticscholar +1 more source
Maize Shrek1 encodes a WD40 protein that regulates pre-rRNA processing in ribosome biogenesis.
The Plant Cell, 2022 Ribosome biogenesis is a fundamental and highly orchestrated process that involves hundreds of ribosome biogenesis factors. Despite advances that have been made in yeast, the molecular mechanism of ribosome biogenesis remains largely unknown in plants ...
Hui Liu +6 more
semanticscholar +1 more source
Cell Reports, 2023 Summary: Increased nucleolar size and activity correlate with aberrant ribosome biogenesis and enhanced translation in cancer cells. One of the first and rate-limiting steps in translation is the interaction of the 40S small ribosome subunit with mRNAs ...
M. Carmen Lafita-Navarro +20 more
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Targeting Ribosome Biogenesis to Combat Tamoxifen Resistance in ER+ve Breast Cancer
Cancers, 2022 Simple Summary Resistance to tamoxifen treatment is an obstacle for ER+ve breast cancer therapy. The overexpression of c-MYC is a known driver of cancer progression and is associated with tamoxifen resistance.
H. Tsoi +4 more
semanticscholar +1 more source