Results 21 to 30 of about 88,539 (283)
Biomedicines, 2022 Ribosome biogenesis is a cellular process critical for protein homeostasis during cell growth and multiplication. Our previous study confirmed up-regulation of ribosome biogenesis during endometriosis progression and malignant transition, thus anti ...
Cherry Yin-Yi Chang +13 more
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Research Progress of Ribosome Biogenesis and Cancer
Zhongliu Fangzhi Yanjiu, 2020 As an important biological process, ribosome biogenesis determines the rate of protein synthesis in cells. However, ribosome biogenesis is abnormally regulated in tumors under strong growth pressure.
QIAN Lili, ZHANG Honghe
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Ribosome biogenesis in disease: new players and therapeutic targets
Signal Transduction and Targeted Therapy, 2023 The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome biogenesis is the process that generates ribosomes and plays an essential role in cell proliferation, differentiation, apoptosis, development, and transformation. The mTORC1,
Lijuan Jiao +7 more
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Cell Reports, 2023 Summary: Increased nucleolar size and activity correlate with aberrant ribosome biogenesis and enhanced translation in cancer cells. One of the first and rate-limiting steps in translation is the interaction of the 40S small ribosome subunit with mRNAs ...
M. Carmen Lafita-Navarro +20 more
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Ribosome Biogenesis Alterations in Colorectal Cancer
Cells, 2020 Many studies have focused on understanding the regulation and functions of aberrant protein synthesis in colorectal cancer (CRC), leaving the ribosome, its main effector, relatively underappreciated in CRC.
Sophie Nait Slimane +7 more
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Frontiers in Microbiology, 2021 Ribosome assembly is an essential and carefully choreographed cellular process. In eukaryotes, several 100 proteins, distributed across the nucleolus, nucleus, and cytoplasm, co-ordinate the step-wise assembly of four ribosomal RNAs (rRNAs) and ...
Mehmet Birikmen +8 more
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Peptides Targeting the Interaction Between Erb1 and Ytm1 Ribosome Assembly Factors
Frontiers in Molecular Biosciences, 2021 Ribosome biogenesis is an emerging therapeutic target. It has been proposed that cancer cells are addicted to ribosome production which is therefore considered a druggable pathway in cancer therapy.
Lidia Orea-Ordóñez +2 more
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Expression Profiling of Ribosome Biogenesis Factors Reveals Nucleolin as a Novel Potential Marker to Predict Outcome in AML Patients. [PDF]
PLoS ONE, 2017 Acute myeloid leukemia (AML) is a heterogeneous disease. Prognosis is mainly influenced by patient age at diagnosis and cytogenetic alterations, two of the main factors currently used in AML patient risk stratification.
Virginie Marcel +11 more
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Frontiers in Microbiology, 2021 BPI-inducible protein A (BipA), a highly conserved paralog of the well-known translational GTPases LepA and EF-G, has been implicated in bacterial motility, cold shock, stress response, biofilm formation, and virulence.
Kwok Jian Goh +7 more
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The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation [PDF]
, 2017 Ribosome assembly requires the concerted expression of hundreds of genes, which are transcribed by all three nuclear RNA polymerases. Transcription elongation involves dynamic interactions between RNA polymerases and chromatin.
Begley, Victoria Sarah +11 more
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