Results 41 to 50 of about 173,360 (283)
Nature Communications, 2021 Ribosomes comprise a large (LSU) and a small subunit (SSU) which are synthesized independently in the nucleolus before being exported into the cytoplasm, where they assemble into functional ribosomes.
Philipp S. Erdmann +7 more
semanticscholar +1 more source
Transcriptional control of ribosome biogenesis in yeast: links to growth and stress signals
Biochemical Society Transactions, 2021 Ribosome biogenesis requires prodigious transcriptional output in rapidly growing yeast cells and is highly regulated in response to both growth and stress signals.
D. Shore, S. Zencir, B. Albert
semanticscholar +1 more source
Open Biology, 2022 Translation machinery is responsible for the production of cellular proteins; thus, cells devote the majority of their resources to ribosome biogenesis and protein synthesis. Single-copy loss of function in the translation machinery components results in
Agustian Surya, Elif Sarinay-Cenik
doaj +1 more source
Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling
Nature Communications, 2021 Ribosome biogenesis requires auxiliary factors to promote folding and assembly of ribosomal proteins and RNA. Particularly, maturation of the peptidyl transferase center (PTC) is mediated by conserved GTPases, but the molecular basis is poorly understood.
H. S. Hillen +7 more
semanticscholar +1 more source
Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation
Nucleic Acids Research, 2021 The m7G cap is ubiquitous on RNAPII-transcribed RNA and has fundamental roles in eukaryotic gene expression, however its in vivo role in mammals has remained unknown.
Alison Galloway +12 more
semanticscholar +1 more source
Cell Reports, 2015 Ribosome biogenesis is a highly complex process requiring many assisting factors. Studies in yeast have yielded comprehensive knowledge of the cellular machinery involved in this process.
Lukas Badertscher +12 more
doaj +1 more source
The deubiquitinase USP36 promotes snoRNP group SUMOylation and is essential for ribosome biogenesis
EMBO Reports, 2021 SUMOylation plays a crucial role in regulating diverse cellular processes including ribosome biogenesis. Proteomic analyses and experimental evidence showed that a number of nucleolar proteins involved in ribosome biogenesis are modified by SUMO. However,
Hyunju Ryu +12 more
semanticscholar +1 more source
Inhibiting eukaryotic ribosome biogenesis
BMC Biology, 2019 Background Ribosome biogenesis is a central process in every growing cell. In eukaryotes, it requires more than 250 non-ribosomal assembly factors, most of which are essential.
Dominik Awad +9 more
doaj +1 more source
snoRNPs: Functions in Ribosome Biogenesis
Biomolecules, 2020 Ribosomes are perhaps the most critical macromolecular machine as they are tasked with carrying out protein synthesis in cells. They are incredibly complex structures composed of protein components and heavily chemically modified RNAs.
Sandeep Ojha +2 more
semanticscholar +1 more source
mBio, 2023 Viruses are known to co-opt host machinery for translation initiation, but less is known about which host factors are required for the formation of ribosomes used to synthesize viral proteins.
Maikke B. Ohlson +8 more
doaj +1 more source