Results 51 to 60 of about 173,360 (283)

The nucleolar protein NOL12 is required for processing of large ribosomal subunit rRNA precursors in Arabidopsis

BMC Plant Biology, 2023
Background NOL12 5′-3′ exoribonucleases, conserved among eukaryotes, play important roles in pre-rRNA processing, ribosome assembly and export. The most well-described yeast counterpart, Rrp17, is required for maturation of 5.8 and 25S rRNAs, whereas ...
Monika Zakrzewska-Placzek, Anna Golisz-Mocydlarz, Michal Krzyszton, Justyna Piotrowska, Malgorzata Lichocka, Joanna Kufel   +5 more
doaj   +1 more source

Suppression of Ribosome Biogenesis by Targeting WD Repeat Domain 12 (WDR12) Inhibits Glioma Stem-Like Cell Growth

Frontiers in Oncology, 2021
Glioma stem-like cells (GSCs) are a subset of tumor cells that initiate malignant growth and promote the therapeutic resistance of glioblastoma, the most lethal primary brain tumor.
Lanjuan Mi, Qinghui Qi, Haowen Ran, Lishu Chen, Da Li, Dake Xiao, Jiaqi Wu, Yan Cai, Songyang Zhang, Yuanyuan Li, Bohan Li, Jiong Xie, Haohao Huang, Tao Li, Tao Zhou, Ailing Li, Ji Qi, Fangye Li, Jianghong Man   +18 more
doaj   +1 more source

Genomic hallmarks and therapeutic targets of ribosome biogenesis in cancer

Briefings Bioinform.
Hyperactive ribosome biogenesis (RiboSis) fuels unrestricted cell proliferation, whereas genomic hallmarks and therapeutic targets of RiboSis in cancers remain elusive, and efficient approaches to quantify RiboSis activity are still limited.
Yue Zang, Xia Ran, Jie Yuan, Hao Wu, Youya Wang, He Li, Huajing Teng, Zhongsheng Sun   +7 more
semanticscholar   +1 more source

The impact of ribosome biogenesis in cancer: from proliferation to metastasis

NAR Cancer
The dysregulation of ribosome biogenesis is a hallmark of cancer, facilitating the adaptation to altered translational demands essential for various aspects of tumor progression.
Sseu-Pei Hwang, C. Denicourt
semanticscholar   +1 more source

Oxidative damage-induced hyperactive ribosome biogenesis participates in tumorigenesis of offspring by cross-interacting with the Wnt and TGF-β1 pathways in IVF embryos

Experimental and Molecular Medicine, 2021
In vitro fertilization (IVF) increases the risk of tumorigenesis in offspring. The increased oxidative damage during IVF may be involved in tumor formation. However, the molecular mechanisms underlying this phenomenon remain largely unclear. Using a well-
Yue Huang, Zhiling Li, En Lin, Pei He, Gaizhen Ru   +4 more
semanticscholar   +1 more source

RNase III, Ribosome Biogenesis and Beyond

Microorganisms, 2021
The ribosome is the universal catalyst for protein synthesis. Despite extensive studies, the diversity of structures and functions of this ribonucleoprotein is yet to be fully understood.
Maxence Lejars, Asaki Kobayashi, Eliane Hajnsdorf   +2 more
doaj   +1 more source

p53 activation during ribosome biogenesis regulates normal erythroid differentiation.

Blood, 2020
The role of ribosome biogenesis in erythroid development is supported by the recognition of erythroid defects in ribosomopathies in both Diamond-Blackfan anemia and 5q- syndrome.
S. Le Goff, Ismael Boussaid, Célia Floquet, Anna Raimbault, I. Hatin, C. Andrieu-Soler, Mohammad Salma, M. Leduc, Emilie-Fleur Gautier, B. Guyot, Diane D'allard, Nathalie Montel-Lehry, S. Ducamp, Amandine Houvert, F. Guillonneau, S. Giraudier, E. Cramer-Bordé, F. Morlé, Jean-Jacques Diaz, O. Hermine, N. Taylor, S. Kinet, F. Verdier, R. Padua, N. Mohandas, P. Gleizes, Eric Soler, P. Mayeux, M. Fontenay   +28 more
semanticscholar   +1 more source

Inhibiting eukaryotic ribosome biogenesis: Mining new tools for basic research and medical applications

Microbial Cell, 2019
The formation of new ribosomes is a fundamental cellular process for each living cell and is tightly interwoven with cell cycle control and proliferation.
Lisa Kofler, Michael Prattes, Helmut Bergler   +2 more
doaj   +1 more source

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

FEBS Letters, EarlyView.
The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mariko Sasaki   +3 more
wiley   +1 more source

Myc as a Regulator of Ribosome Biogenesis and Cell Competition: A Link to Cancer

International Journal of Molecular Sciences, 2020
The biogenesis of ribosomes is a finely regulated multistep process linked to cell proliferation and growth—processes which require a high rate of protein synthesis.
F. Destefanis, Valeria Manara, P. Bellosta   +2 more
semanticscholar   +1 more source