Results 81 to 90 of about 26,910 (280)

Synergistic Tuning of Conformational Dynamics, Electron Tunneling, and Substrate Positioning Enhances Electron Transfer in a P450 Chimera for Calcifediol Biosynthesis

Advanced Science, EarlyView.
A synergistic electron transfer (ET) optimization strategy modulating conformational dynamics, ET pathway, and substrate orientation is proposed for self‐sufficient cytochrome P450s. Guided by this strategy, a P450 variant with improved ET and catalytic efficiency was identified, and the underlying molecular basis was revealed by computational analysis.
Ziqi Liang, Xitong Song, Shuming Cheng, Yiwen Shen, Jie Zhang, Yaru Wang, Huiying Luo, Bin Yao, Binju Wang, Tao Tu   +9 more
wiley   +1 more source

Ribosome-Inactivating Proteins from Plants: A Historical Overview [PDF]

Molecules, 2016
This review provides a historical overview of the research on plant ribosome-inactivating proteins (RIPs), starting from the first studies at the end of eighteenth century involving the purification of abrin and ricin, as well as the immunological experiments of Paul Erlich. Interest in these plant toxins was revived in 1970 by the observation of their
BOLOGNESI, ANDREA, BORTOLOTTI, MASSIMO, MAIELLO, STEFANIA, BATTELLI, MARIA GIULIA, POLITO, LETIZIA   +4 more
openaire   +3 more sources

Burkholderia Lethal Factor 1, a Novel Anti-Cancer Toxin, Demonstrates Selective Cytotoxicity in MYCN-Amplified Neuroblastoma Cells

Toxins, 2018
Immunotoxins are being investigated as anti-cancer therapies and consist of a cytotoxic enzyme fused to a cancer targeting antibody. All currently used toxins function via the inhibition of protein synthesis, making them highly potent in both healthy and
Aleksander Rust, Sajid Shah, Guillaume M. Hautbergue, Bazbek Davletov   +3 more
doaj   +1 more source

Characterization of a new toxin from the entomopathogenic fungus Metarhizium anisopliae: the ribotoxin anisoplin [PDF]

, 2016
Metarhizium anisopliae is an entomopathogenic fungus relevant in biotechnology with applications like malaria vector control. Studies of its virulence factors are therefore of great interest.
Budia, Flor, García Ortega, Lucía, Gavilanes, José, Martínez del Pozo, Álvaro, Medina, Pilar, Olombrada, Miriam   +5 more
core   +2 more sources

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

Cascade Therapy of Periodontitis via Sequential Release of Ribosome‐Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF‐Based System

Advanced Science, EarlyView.
This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen, Zheng Xu, Yunmo Xue, Shanshan Liu, Xiang Zhang, Jingyao Guo, Minhui Yao, Yue Liu, Xiaolin Lu, Jieshu Qian, Qian Ma   +10 more
wiley   +1 more source

Production of Recombinant Gelonin Using an Automated Liquid Chromatography System

Toxins, 2020
Advances in recombinant DNA technology have opened up new possibilities of exploiting toxic proteins for therapeutic purposes. Bringing forth these protein toxins from the bench to the bedside strongly depends on the availability of production methods ...
Maria E. B. Berstad, Lawrence H. Cheung, Anette Weyergang   +2 more
doaj   +1 more source

Genetic and Phenotypic Features of the Five Known Polyaminopathies: A Critical Narrative Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Polyaminopathies are a recently described family of rare genetic neurodevelopmental disorders. Polyaminopathies disrupt the biosynthesis of the primary polyamines: putrescine, spermidine, and spermine. Snyder–Robinson syndrome results from hemizygous loss‐of‐function variants in the spermine synthase (SMS) gene, resulting in decreased or ...
Elizabeth A. VanSickle, Sara M. Sarasua, Tracy Lowe, Christopher L. Farrell, Luigi Boccuto, Charles Schwartz, Anthony E. Pegg, Angela Peron, Victor Faundes, Mythily Ganapathi, Wendy K. Chung, Alban Ziegler, Floris Hofstede, Clément Prouteau, Katharina Steindl, Colleen Olson, Orrin Devinsky, Teresa L. Mastracci, Robert A. Casero Jr., Tracy Murray Stewart, Susan Gilmour, Teri Koerner, Mary Jo Kutler, Surender Rajasekaran, Julianne Michael, André S. Bachmann, Caleb P. Bupp   +26 more
wiley   +1 more source

Hyperuricaemia, Xanthine Oxidoreductase and Ribosome‐Inactivating Proteins from Plants: The Contributions of Fiorenzo Stirpe to Frontline Research

Molecules, 2017
The enzymes called ribosome‐inactivating proteins (RIPs) that are able to depurinate  nucleic acids and arrest vital cellular functions, including protein synthesis, are still a frontline  research field, mostly because of their promising medical ...
Andrea Bolognesi, Massimo Bortolotti, Maria Giulia Battelli, Letizia Polito   +3 more
doaj   +1 more source

Charged and hydrophobic surfaces on the a chain of shiga-like toxin 1 recognize the C-terminal domain of ribosomal stalk proteins. [PDF]

PLoS ONE, 2012
Shiga-like toxins are ribosome-inactivating proteins (RIP) produced by pathogenic E. coli strains that are responsible for hemorrhagic colitis and hemolytic uremic syndrome.
Andrew J McCluskey, Eleonora Bolewska-Pedyczak, Nick Jarvik, Gang Chen, Sachdev S Sidhu, Jean Gariépy   +5 more
doaj   +1 more source