Results 101 to 110 of about 30,415 (253)

Hepatitis C virus RNA replication depends on specific cis- and trans-acting activities of viral nonstructural proteins [PDF]

, 2015
Many positive-strand RNA viruses encode genes that can function in trans, whereas other genes are required in cis for genome replication. The mechanisms underlying trans- and cis-preferences are not fully understood.
Diamond, Michael S, Kazakov, Teymur, Kohlway, Andrew, Lindenbach, Brett D, Ramanathan, Harish N, Yang, Feng   +5 more
core   +4 more sources

Dynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics

The FEBS Journal, EarlyView.
We describe the CD9 interactome in epithelial cells for the first time. The interactome is diverse and dynamic and changes dependent on infection with specific bacteria. We validate these data by showing functional interaction between CD9 with CD44 or CD147. We therefore demonstrate that CD9 is a universal organiser of bacterial adhesion platforms able
Paige A. Wolverson, Isabel Fernandes Parreira, Ruth H. Thompson, Mark O. Collins, Jonathan G. Shaw, Luke R. Green   +5 more
wiley   +1 more source

Identification of a VapBC toxin–antitoxin system in a thermophilic bacterium Thermus thermophilus HB27 [PDF]

, 2017
There are 12 putative toxin–antitoxin (TA) loci in the Thermus thermophilus HB27 genome, including four VapBC and three HicBA families. Expression of these seven putative toxin genes in Escherichia coli demonstrated that one putative VapC toxin TTC0125 ...
Fan Yuqi, Hoshino Takayuki, Nakamura Akira, 中村 顕, 星野 貴行   +4 more
core   +2 more sources

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Expression of the alpha-thionin gene from barley in tobacco confers enhanced resistance to bacterial pathogens [PDF]

, 1993
Thionins are cysteine-rich, 5 kDa polypeptides which are toxic to plant pathogens in vitro. Expression of the gene encoding alpha-thionin from barley endosperm, under the 35S promoter from cauliflower mosaic virus, conferred to transgenic tobacco ...
Carmona Quiles, Maria Jose, Fernandez, Jose A., García Olmedo, Francisco, Lopez Fando, J.J., Molina Fernández, Antonio   +4 more
core   +2 more sources

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Alteraciones histológicas causadas por la administración intraperitoneal de ebulina en ratones [PDF]

, 2017
La ebulina es una proteína inhibidora de ribosomas tipo 2 con actividad lectina (RIL) aislada del saúco enano. Los frutos del saúco se han consumido desde la antigüedad por sus atribuidos efectos medicinales.
Vicente Pardo, Andrea
core  

Comparative study of lectin domains in model species : new insights into evolutionary dynamics [PDF]

, 2017
Lectins are present throughout the plant kingdom and are reported to be involved in diverse biological processes. In this study, we provide a comparative analysis of the lectin families from model species in a phylogenetic framework. The analysis focuses
Dang, Liuyi, De Schutter, Kristof, Eggermont, Lore, Tsaneva, Mariya Tsankova, Van Damme, Els, Van Holle, Sofie   +5 more
core   +3 more sources

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

TaRIP2 Positively Regulates Wheat Pollen Wall Formation Through MYB80‐Controlled Lipid Metabolism

Plant Biotechnology Journal, EarlyView.
ABSTRACT Male‐sterile genes and mutants are critical for hybrid seed production in monocotyledonous crops. Lipids are essential structural components of male reproductive organs, such as the anther and pollen. Here, we show that the pollen‐preferential gene TaRIP2 is essential for wheat anther development and pollen formation. RT‐qPCR analysis revealed
Ran Han, Aifeng Liu, Guang Qi, Chunhao Fang, XiaoLu Wang, Wenjing Xu, Kai Wang, Jihu Li, Qingqi Fan, Dungong Cheng, Faji Li, Haosheng Li, Jianjun Liu, Genying Li, Cheng Liu   +14 more
wiley   +1 more source