Results 21 to 30 of about 47,955 (276)
riboviz: analysis and visualization of ribosome profiling datasets [PDF]
BMC Bioinformatics, 2017 Background Using high-throughput sequencing to monitor translation in vivo, ribosome profiling can provide critical insights into the dynamics and regulation of protein synthesis in a cell.
Oana Carja +4 more
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Identification and analysis of ribosome-associated lncRNAs using ribosome profiling data [PDF]
BMC Genomics, 2018 Background Although the number of discovered long non-coding RNAs (lncRNAs) has increased dramatically, their biological roles have not been established.
Chao Zeng +2 more
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Advances in ribosome profiling technologies. [PDF]
Biochem Soc TransRibosome profiling (or Ribo-seq) has emerged as a powerful approach for revealing the regulatory mechanisms of protein synthesis, on the basis of deep sequencing of ribosome footprints. Recent innovations in Ribo-seq technologies have significantly enhanced their sensitivity, specificity, and resolution.
Tomuro K, Iwasaki S.
europepmc +3 more sources
Ribosome Profiling of Plants. [PDF]
Methods Mol Biol, 2023 Translation is a key step in control of gene expression, yet most analyses of global responses to a stimulus focus on transcription and the transcriptome. For RNA viruses in particular, which have no DNA-templated transcriptional control, control of viral and host translation is crucial.
Sonia J, Kanodia P, Lozier Z, Miller WA.
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Profiling of Mycoplasma gallisepticum Ribosomes [PDF]
Acta Naturae, 2015 The development of high-throughput technologies is increasingly resulting in identification of numerous cases of low correlation between mRNA and the protein level in cells. These controversial observations were made on various bacteria, such as E. coli, Desulfovibrio vulgaris, and Lactococcus lactis.
FISUNOV G.Y. +4 more
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F1000Research, 2020 Ribosome profiling provides the opportunity to evaluate translation kinetics at codon level resolution. Here, we describe ribosome profiling data, generated from two HEK293T cell lines.
Aikaterini Alexaki +11 more
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The awesome power of ribosome profiling [PDF]
RNA, 2015 Ribosome profiling has proved to be a fantastic innovation which has revealed so much about mRNA translation that had previously gone unrecognized. The RNA community owes Jonathan Weissman and Nick Ingolia a deep sense of gratitude for conceiving the approach in the first place, and for their detailed optimization of the methodology. The origins of the
Jackson, Richard, Standart, Nancy
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PLoS Computational Biology, 2020 Ribosome profiling, an application of nucleic acid sequencing for monitoring ribosome activity, has revolutionized our understanding of protein translation dynamics.
Jordan A Berg +7 more
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Ribonuclease selection for ribosome profiling [PDF]
Nucleic Acids Research, 2016 Ribosome profiling has emerged as a powerful method to assess global gene translation, but methodological and analytical challenges often lead to inconsistencies across labs and model organisms. A critical issue in ribosome profiling is nuclease treatment of ribosome-mRNA complexes, as it is important to ensure both stability of ribosomal particles and
Gerashchenko, Maxim, Gladyshev, Vadim
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Development of a tissue-specific ribosome profiling approach in Drosophila enables genome-wide evaluation of translational adaptations. [PDF]
PLoS Genetics, 2017 Recent advances in next-generation sequencing approaches have revolutionized our understanding of transcriptional expression in diverse systems. However, measurements of transcription do not necessarily reflect gene translation, the process of ultimate ...
Xun Chen, Dion Dickman
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