Results 21 to 30 of about 411,205 (272)
A rapid protocol for ribosome profiling of low input samples. [PDF]
Nucleic Acids Res, 2023 Ribosome profiling provides quantitative, comprehensive, and high-resolution snapshots of cellular translation by the high-throughput sequencing of short mRNA fragments that are protected by ribosomes from nucleolytic digestion.
Meindl A +12 more
europepmc +6 more sources
Ribosome profiling reveals downregulation of UMP biosynthesis as the major early response to phage infection [PDF]
Microbiology SpectrumBacteria have evolved diverse defense mechanisms to counter bacteriophage attacks. Genetic programs activated upon infection characterize phage–host molecular interactions and ultimately determine the outcome of the infection.
Patrick B. F. O’Connor +5 more
doaj +2 more sources
Identification and analysis of ribosome-associated lncRNAs using ribosome profiling data [PDF]
BMC Genomics, 2018 Background Although the number of discovered long non-coding RNAs (lncRNAs) has increased dramatically, their biological roles have not been established.
Chao Zeng +2 more
doaj +3 more sources
riboviz: analysis and visualization of ribosome profiling datasets [PDF]
BMC Bioinformatics, 2017 Background Using high-throughput sequencing to monitor translation in vivo, ribosome profiling can provide critical insights into the dynamics and regulation of protein synthesis in a cell.
Oana Carja +4 more
doaj +3 more sources
Advances in ribosome profiling technologies. [PDF]
Biochem Soc TransRibosome profiling (or Ribo-seq) has emerged as a powerful approach for revealing the regulatory mechanisms of protein synthesis, on the basis of deep sequencing of ribosome footprints. Recent innovations in Ribo-seq technologies have significantly enhanced their sensitivity, specificity, and resolution.
Tomuro K, Iwasaki S.
europepmc +3 more sources
A tool for analyzing and visualizing ribo-seq data at the isoform level
BMC Bioinformatics, 2021 Background Translational regulation is one important aspect of gene expression regulation. Dysregulation of translation results in abnormal cell physiology and leads to diseases.
Wei-Sheng Wu +5 more
doaj +1 more source
Ribosome Profiling of Plants. [PDF]
Methods Mol Biol, 2023 Translation is a key step in control of gene expression, yet most analyses of global responses to a stimulus focus on transcription and the transcriptome. For RNA viruses in particular, which have no DNA-templated transcriptional control, control of viral and host translation is crucial.
Sonia J, Kanodia P, Lozier Z, Miller WA.
europepmc +3 more sources
Profiling of Mycoplasma gallisepticum Ribosomes [PDF]
Acta Naturae, 2015 The development of high-throughput technologies is increasingly resulting in identification of numerous cases of low correlation between mRNA and the protein level in cells. These controversial observations were made on various bacteria, such as E. coli, Desulfovibrio vulgaris, and Lactococcus lactis.
FISUNOV G.Y. +4 more
openaire +3 more sources
Genome-wide Survey of Ribosome Collision
Cell Reports, 2020 Summary: Ribosome movement is not always smooth and is rather often impeded. For ribosome pauses, fundamental issues remain to be addressed, including where ribosomes pause on mRNAs, what kind of RNA/amino acid sequence causes this pause, and the ...
Peixun Han +10 more
doaj +1 more source
A snapshot of translation in Mycobacterium tuberculosis during exponential growth and nutrient starvation revealed by ribosome profiling [PDF]
, 2021 Mycobacterium tuberculosis, which causes tuberculosis, can undergo prolonged periods of non-replicating persistence in the host. The mechanisms underlying this are not fully understood, but translational regulation is thought to play a role.
Clark, T.G. +3 more
core +1 more source