Results 41 to 50 of about 78,844 (296)
A novel class of microRNA-recognition elements that function only within open reading frames. [PDF]
, 2018 MicroRNAs (miRNAs) are well known to target 3' untranslated regions (3' UTRs) in mRNAs, thereby silencing gene expression at the post-transcriptional level.
A Aizer +85 more
core +2 more sources
eLife, 2020 Ribosomal profiling has shed new light on how ribosomes can ignore stop codons in messenger RNA.
Kim M Keeling, David M Bedwell
doaj +1 more source
New technologies accelerate the exploration of non-coding RNAs in horticultural plants. [PDF]
, 2017 Non-coding RNAs (ncRNAs), that is, RNAs not translated into proteins, are crucial regulators of a variety of biological processes in plants. While protein-encoding genes have been relatively well-annotated in sequenced genomes, accounting for a small ...
Hu, Rongbin +4 more
core +3 more sources
HRPDviewer: human ribosome profiling data viewer [PDF]
Database, 2018 Translational regulation plays an important role in protein synthesis. Dysregulation of translation causes abnormal cell physiology and leads to diseases such as inflammatory disorders and cancers. An emerging technique, called ribosome profiling (ribo-seq), was developed to capture a snapshot of translation.
Wei-Sheng Wu +8 more
openaire +2 more sources
N-terminal proteomics assisted profiling of the unexplored translation initiation landscape in Arabidopsis thaliana [PDF]
, 2017 Proteogenomics is an emerging research field yet lacking a uniform method of analysis. Proteogenomic studies in which N-terminal proteomics and ribosome profiling are combined, suggest that a high number of protein start sites are currently missing in ...
Gevaert, Kris +8 more
core +1 more source
The awesome power of ribosome profiling [PDF]
RNA, 2015 Ribosome profiling has proved to be a fantastic innovation which has revealed so much about mRNA translation that had previously gone unrecognized. The RNA community owes Jonathan Weissman and Nick Ingolia a deep sense of gratitude for conceiving the approach in the first place, and for their detailed optimization of the methodology. The origins of the
Jackson, Richard, Standart, Nancy
openaire +2 more sources
Dissecting apoptosis the omics way [PDF]
, 2013 A combined analysis of transcription, translation and protein degradation reveals the global effects of an anticancer drug on tumour ...
Agard +8 more
core +2 more sources
eLife, 2022 Protein methylation occurs predominantly on lysine and arginine residues, but histidine also serves as a methylation substrate. However, a limited number of enzymes responsible for this modification have been reported.
Eriko Matsuura-Suzuki +12 more
doaj +1 more source
eIF1 modulates the recognition of suboptimal translation initiation sites and steers gene expression via uORFs [PDF]
, 2017 Alternative translation initiation mechanisms such as leaky scanning and reinitiation potentiate the polycistronic nature of human transcripts. By allowing for reprogrammed translation, these mechanisms can mediate biological responses to stimuli.
Fijalkowska, Daria +5 more
core +1 more source
sORFs.org : a repository of small ORFs identified by ribosome profiling [PDF]
, 2015 With the advent of ribosome profiling, a next generation sequencing technique providing a ‘snap-shot’ of translated mRNA in a cell, many short open reading frames (sORFs) with were identified.
Crappé, Jeroen +5 more
core +3 more sources