Stochastic theory of protein synthesis and polysome: ribosome profile on a single mRNA transcript [PDF]
Journal of Theoretical Biology, vol.289, 36-46 (2011), 2011 The process of polymerizing a protein by a ribosome, using a messenger RNA (mRNA) as the corresponding template, is called {\it translation}. Ribosome may be regarded as a molecular motor for which the mRNA template serves also as the track.
Agirrezabala +52 more
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Antibiotics and the ribosome [PDF]
Molecular Microbiology, 2006 SummaryThe ribosome is one of the main antibiotic targets in the cell. Recent years brought important insights into the mode of interaction of antibiotics with the ribosome and mechanisms of antibiotic action. Ribosome crystallography provided a detailed view of the interactions between antibiotics and rRNA.
Alexander S. Mankin, Tanel Tenson
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Nascent polypeptide chains exit the ribosome in the same relative position in both eucaryotes and procaryotes. [PDF]
, 1983 We located the polypeptide nascent chain as it leaves cytoplasmic ribosomes from the plant Lemna gibba by immune electron microscopy using antibodies against the small subunit of the enzyme ribulose-1,5-bisphosphate carboxylase.
Bernabeu, C +4 more
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The role of GTP in transient splitting of 70S ribosomes by RRF (ribosome recycling factor) and EF-G (elongation factor G). [PDF]
, 2008 Ribosome recycling factor (RRF), elongation factor G (EF-G) and GTP split 70S ribosomes into subunits. Here, we demonstrated that the splitting was transient and the exhaustion of GTP resulted in re-association of the split subunits into 70S ribosomes ...
Hirokawa, Go +3 more
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Evidence of novel type of ribosome in eukaryotic intermediate flatworm [PDF]
, 2008 In all organisms, messenger-directed protein synthesis is catalyzed by ribonucleoprotein particles called ribosomes. A ribosome is typically composed of one small and one large subunit which contain one short (18S) and one long (28S) rRNAs, respectively.
Haoran H. Wang +3 more
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Optimal localization patterns in bacterial protein synthesis
, 2018 In $\textit{Escherichia coli}$ bacterium, the molecular compounds involved in protein synthesis, messenger RNAs (mRNAs) and ribosomes, show marked intracellular localization patterns.
Castellana, Michele, Nguyen, Jacky
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Biotechnology Journal, 2012 AbstractSee accompanying article by Contreras‐Martin et al.
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Extensive evolution of cereal ribosome-inactivating proteins translates into unique structural features, activation mechanisms, and physiological roles [PDF]
, 2017 Ribosome-inactivating proteins (RIPs) are a class of cytotoxic enzymes that can depurinate rRNAs thereby inhibiting protein translation. Although these proteins have also been detected in bacteria, fungi, and even some insects, they are especially ...
De Zaeytijd, Jeroen, Van Damme, Els
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Models of protein production along the cell cycle: an investigation of possible sources of noise
, 2020 In this article, we quantitatively study, through stochastic models, the efects of several intracellular phenomena, such as cell volume growth, cell division, gene replication as well as fuctuations of available RNA polymerases and ribosomes.
Dessalles, Renaud +2 more
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Nature Reviews Molecular Cell Biology, 2015 A prophetic theoretical article, which hypothesized that ribosomes have regulatory roles in controlling gene expression, inspired Maria Barna to rethink the value of purely theoretical scientific publications.
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