Results 1 to 10 of about 178,340 (359)
Selective translation by alternative bacterial ribosomes [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Many organisms, including bacteria, code for multiple paralogues of some ribosomal protein subunits. The relative contribution of these alternative subunits to ribosome function and protein synthesis is unknown and controversial.
Yuxiang Chen +6 more
openalex +2 more sources
Neuronal ribosomes exhibit dynamic and context-dependent exchange of ribosomal proteins
Nature Communications, 2021 Owing to their morphological complexity and dense network connections, neurons modify their proteomes locally, using mRNAs and ribosomes present in the neuropil (tissue enriched for dendrites and axons).
Claudia M Fusco +2 more
exaly +2 more sources
Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes
Science, 2018 Structure of the largest, most complex ribosome Ribosomes are two-subunit ribonucleoprotein assemblies that catalyze the translation of messenger RNA into protein. Ribosomal RNAs (rRNAs) play key structural and functional roles. Ramrath et al. report the
David J F Ramrath +2 more
exaly +2 more sources
Breaking the genetic code – a new revolutionary stage in the development of molecular biology: 1968 Nobel Prize laureates M. W. Nirenberg, H. G. Khorana, R. W. Holley [PDF]
The Ukrainian Biochemical Journal, 2021 This review presents the life stories of M. Nirenberg, H. Khorana, and R. Holley, winners of the 1968 Nobel Prize in Physiology or Medicine, the history of the discoveries made by these scientists, and the methodological approaches used in their works ...
O. P. Matyshevska +2 more
doaj +1 more source
How Ribosomes Translate Cancer
Cancer Discovery, 2017 Kim De Keersmaecker, Jonathan D Dinman
exaly +2 more sources
Peptidyl tRNA Hydrolase Is Required for Robust Prolyl-tRNA Turnover in Mycobacterium tuberculosis
mBio, 2023 Enzymes involved in rescuing stalled ribosomes and recycling translation machinery are ubiquitous in bacteria and required for growth. Peptidyl tRNA drop-off is a type of abortive translation that results in the release of a truncated peptide that is ...
Francesca G. Tomasi +8 more
doaj +1 more source
Computational and Functional Analysis of Structural Features in the ZAKα Kinase
Cells, 2023 The kinase ZAKα acts as the proximal sensor of translational impairment and ribotoxic stress, which results in the activation of the MAP kinases p38 and JNK. Despite recent insights into the functions and binding partners of individual protein domains in
Valdemar Brimnes Ingemann Johansen +4 more
doaj +1 more source
Nature Communications, 2021 The polyglutamine expansion of huntingtin (mHTT) causes Huntington disease (HD) and neurodegeneration, but the mechanisms remain unclear. Here, we found that mHtt promotes ribosome stalling and suppresses protein synthesis in mouse HD striatal neuronal ...
M. Eshraghi +12 more
semanticscholar +1 more source
Antibiotics, 2023 Oxazolidinones are a broad-spectrum class of synthetic antibiotics that bind to the 50S ribosomal subunit of Gram-positive and Gram-negative bacteria.
McKenna E. Buckley +5 more
doaj +1 more source