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Macromolecular Structure Assembly as a Novel Antibiotic Target
Antibiotics, 2022 This review discusses the inhibition of macromolecular structure formation as a novel and under-investigated drug target. The disruption of cell wall structures by penicillin-binding protein interactions is one potential target.
Scott Champney
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Mass spectrometry of ribosomes and ribosomal subunits [PDF]
Proceedings of the National Academy of Sciences, 1998 Nanoflow electrospray ionization has been used to introduce intact Escherichia coli ribosomes into the ion source of a mass spectrometer. Mass spectra of remarkable quality result from a partial, but selective, dissociation of the particles within the mass spectrometer.
Benjamin, DR +4 more
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The Effects of Deregulated Ribosomal Biogenesis in Cancer
Biomolecules, 2023 Ribosomes are macromolecular ribonucleoprotein complexes assembled from RNA and proteins. Functional ribosomes arise from the nucleolus, require ribosomal RNA processing and the coordinated assembly of ribosomal proteins (RPs), and are frequently ...
Yiwei Lu, Shizhuo Wang, Yisheng Jiao
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Mediating Ribosomal Competition by Splitting Pools [PDF]
LCSS Vol 5 Issue 5 (Nov 2020), 2020 Synthetic biology constructs often rely upon the introduction of "circuit" genes into host cells, in order to express novel proteins and thus endow the host with a desired behavior. The expression of these new genes "consumes" existing resources in the cell, such as ATP, RNA polymerase, amino acids, and ribosomes. Ribosomal competition among strands of
arxiv +1 more source
Ribosomal Biogenesis and Heterogeneity in Development, Disease, and Aging
Epigenomes, 2023 Although reported in the literature, ribosome heterogeneity is a phenomenon whose extent and implications in cell and organismal biology is not fully appreciated.
Rowshan Ara Islam, Charalampos Rallis
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Nuclear 80S Ribosomes Present Across the Stages of Cell Cycle in Drosophila Melanogaster Cells
UMYU Journal of Microbiology Research, 2023 Nuclear translation has been a subject of controversy between scientists for over 5 decades. Despite the existence of evidence to the contrary, most biologists agree that translation exclusively takes place in the cytoplasm of eukaryotes.
Akilu Abdullahi, Saverio Brogna
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The ABCs of the ribosome [PDF]
Nature Structural & Molecular Biology, 2014 An ABC protein that binds the ribosomal exit site suggests a new mechanism for direct regulation of translation in response to changing ATP levels in the cell.
Fredrick, Kurt, Ibba, Michael
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Frontiers in Plant Science, 2013 Isolation of biologically active cell components from multicellular eukaryotic organisms often poses difficult challenges such as low yields and inability to retain the integrity and functionality of the purified compound. We previously identified a cap-
Vera Aleksey Stupina +1 more
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Ribosomal proteins: functions beyond the ribosome [PDF]
Journal of Molecular Cell Biology, 2015 Although ribosomal proteins are known for playing an essential role in ribosome assembly and protein translation, their ribosome-independent functions have also been greatly appreciated. Over the past decade, more than a dozen of ribosomal proteins have been found to activate the tumor suppressor p53 pathway in response to ribosomal stress. In addition,
Peng Liao +4 more
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The PDB and the ribosome [PDF]
Journal of Biological Chemistry, 2021 This essay, which was written to commemorate the 50th anniversary of the Protein Data Bank, opens with some comments about the intentions of the scientists who pressed for its establishment and the nature of services it provides. It includes a brief account of the events that resulted in the determination of the crystal structure of the large ribosomal
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