Results 1 to 10 of about 177,240 (312)
Neuronal ribosomes exhibit dynamic and context-dependent exchange of ribosomal proteins
Nature Communications, 2021 Owing to their morphological complexity and dense network connections, neurons modify their proteomes locally, using mRNAs and ribosomes present in the neuropil (tissue enriched for dendrites and axons).
Claudia M Fusco +2 more
exaly +2 more sources
Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes
Science, 2018 Structure of the largest, most complex ribosome Ribosomes are two-subunit ribonucleoprotein assemblies that catalyze the translation of messenger RNA into protein. Ribosomal RNAs (rRNAs) play key structural and functional roles. Ramrath et al. report the
David J F Ramrath +2 more
exaly +2 more sources
How Ribosomes Translate Cancer
Cancer Discovery, 2017 Kim De Keersmaecker, Jonathan D Dinman
exaly +2 more sources
Nature Communications, 2021 The polyglutamine expansion of huntingtin (mHTT) causes Huntington disease (HD) and neurodegeneration, but the mechanisms remain unclear. Here, we found that mHtt promotes ribosome stalling and suppresses protein synthesis in mouse HD striatal neuronal ...
M. Eshraghi +12 more
semanticscholar +1 more source
Specialized ribosomes: a new frontier in gene regulation and organismal biology
Nature Reviews Molecular Cell Biology, 2012 Shifeng Xue, Maria Barna
exaly +2 more sources
Ribosomes are optimized for autocatalytic production
Nature, 2017 Shlomi Reuveni +2 more
exaly +2 more sources
Structure of Gcn1 bound to stalled and colliding 80S ribosomes
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance There is growing evidence that collisions between ribosomes represent a cellular signal for activating multiple stress pathways, such as ribosome-associated quality control (RQC), the ribotoxic stress response, and the integrated stress ...
A. Pochopien +6 more
semanticscholar +1 more source
Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes
bioRxiv, 2020 Cells adjust to nutrient deprivation by reversible translational shut down. This is accompanied by maintaining inactive ribosomes in a hibernation state, where they are bound by proteins with inhibitory and protective functions.
J. N. Wells +9 more
semanticscholar +1 more source
Collided ribosomes form a unique structural interface to induce Hel2‐driven quality control pathways
EMBO Journal, 2019 Ribosome stalling triggers quality control pathways targeting the mRNA (NGD: no‐go decay) and the nascent polypeptide (RQC: ribosome‐associated quality control). RQC requires Hel2‐dependent uS10 ubiquitination and the RQT complex in yeast.
Ken Ikeuchi +9 more
semanticscholar +1 more source