Results 61 to 70 of about 239,527 (406)

Distribution of dwell times of a ribosome: effects of infidelity, kinetic proofreading and ribosome crowding [PDF]

Physical Biology, 8 (2011) 026005, 2010
Ribosome is a molecular machine that polymerizes a protein where the sequence of the amino acid residues, the monomers of the protein, is dictated by the sequence of codons (triplets of nucleotides) on a messenger RNA (mRNA) that serves as the template. The ribosome is a molecular motor that utilizes the template mRNA strand also as the track. Thus, in
arxiv   +1 more source

Growth-laws and invariants from ribosome biogenesis in lower Eukarya [PDF]

Phys. Rev. Research 3, 013020 (2021), 2020
Eukarya and Bacteria are the most evolutionarily distant domains of life, which is reflected by differences in their cellular structure and physiology. For example, Eukarya feature membrane-bound organelles such as nuclei and mitochondria, whereas Bacteria have none.
arxiv   +1 more source

Puromycin Sensitivity of Ribosomal Label after Incorporation of 14C-Labelled Amino Acids into Isolated Mitochondria from Neurospora crassa [PDF]

, 1969
Radioactive amino acids were incorporated into isolated mitochondria from Neurospora crassa. Then the mitochondrial ribosomes were isolated and submitted to density gradient centrifugation. A preferential labelling of polysomes was observed.
Dingman C. W., Dingman C. W., Kuntzel H., Kuntzel H., Luck D. J. L., Neupert W., Noll H., Peacock A. C., Rifkin M. R.   +8 more
core   +2 more sources

Modelling the effect of ribosome mobility on the rate of protein synthesis [PDF]

Eur. Phys. J. E 44, 19 (2021), 2020
Translation is one of the main steps in the synthesis of proteins. It consists of ribosomes that translate sequences of nucleotides encoded on mRNA into polypeptide sequences of amino acids. Ribosomes bound to mRNA move unidirectionally, while unbound ribosomes diffuse in the cytoplasm.
arxiv   +1 more source

Osmotic regulation of alpha-amylase synthesis and polyribosome formation in aleurone cells of barley. [PDF]

, 1973
Water stress inhibits the gibberellic acid (GA(3))-induced synthesis of alpha-amylase in aleurone layers of barley (Hordeum vulgare L.). Electron microscope evidence indicates that the effect of water stress induced by 0.6 M solutions of polyethylene ...
Armstrong, J, JONES, Russell L.
core   +2 more sources

Evidence for rRNA 2′-O-methylation plasticity: Control of intrinsic translational capabilities of human ribosomes

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance Translational control is a cornerstone of gene-expression regulation in physiological and pathological contexts. The contribution of nonribosomal factors, including messenger RNAs (mRNAs) and mRNA-bound factors, to translational control have
J. Erales, V. Marchand, Baptiste Panthu, Sandra Gillot, S. Belin, S. Ghayad, M. Garcia, Florian Lafôrets, V. Marcel, Agnès Baudin-Baillieu, P. Bertin, Y. Couté, A. Adrait, M. Meyer, Gabriel Thérizols, M. Yusupov, O. Namy, T. Ohlmann, Y. Motorin, Frédéric Catez, Jean-Jacques Diaz   +20 more
semanticscholar   +1 more source

The Stringent Response Inhibits 70S Ribosome Formation in Staphylococcus aureus by Impeding GTPase-Ribosome Interactions

mBio, 2021
During nutrient limitation, bacteria produce the alarmones (p)ppGpp as effectors of a stress signaling network termed the stringent response. RsgA, RbgA, Era, and HflX are four ribosome-associated GTPases (RA-GTPases) that bind to (p)ppGpp in ...
Daniel J. Bennison, Jose A. Nakamoto, Timothy D. Craggs, Pohl Milón, John B. Rafferty, Rebecca M. Corrigan   +5 more
doaj   +1 more source

Traffic of interacting ribosomes: effects of single-machine mechano-chemistry on protein synthesis [PDF]

Physical Review E 75, 021902 (2007), 2006
Many ribosomes simultaneously move on the same messenger RNA (mRNA), each separately synthesizing the protein coded by the mRNA. Earlier models of ribosome traffic represent each ribosome by a ``self-propelled particle'' and capture the dynamics by an extension of the totally asymmetric simple exclusion process (TASEP).
arxiv   +2 more sources

Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes

Science, 2018
Structure of the largest, most complex ribosome Ribosomes are two-subunit ribonucleoprotein assemblies that catalyze the translation of messenger RNA into protein. Ribosomal RNAs (rRNAs) play key structural and functional roles. Ramrath et al. report the
D.J.F. Ramrath, M. Niemann, M. Leibundgut, P. Bieri, C. Prange, E. Horn, A. Leitner, D. Boehringer, A. Schneider, N. Ban   +9 more
semanticscholar   +1 more source

Control of ribosome traffic by position-dependent choice of synonymous codons [PDF]

Phys. Biol. 10 (2013) 056011, 2013
Messenger RNA encodes a sequence of amino acids by using codons. For most amino acids there are multiple synonymous codons that can encode the amino acid. The translation speed can vary from one codon to another, thus there is room for changing the ribosome speed while keeping the amino acid sequence and hence the resulting protein.
arxiv   +1 more source