Results 21 to 30 of about 12,203 (191)
Identification and characterisation of thiamine pyrophosphate (TPP) riboswitch in Elaeis guineensis.
PLoS ONE, 2020 The oil palm (Elaeis guineensis) is an important crop in Malaysia but its productivity is hampered by various biotic and abiotic stresses. Recent studies suggest the importance of signalling molecules in plants in coping against stresses, which includes ...
Atiqah Subki +4 more
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Microbial Cell Factories, 2022 Background In vivo biosensors have a wide range of applications, ranging from the detection of metabolites to the regulation of metabolic networks, providing versatile tools for synthetic biology and metabolic engineering.
Kun-Qiang Hong +4 more
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A riboswitch-based inducible gene expression system for mycobacteria. [PDF]
PLoS ONE, 2012 Research on the human pathogen Mycobacterium tuberculosis (Mtb) would benefit from novel tools for regulated gene expression. Here we describe the characterization and application of a synthetic riboswitch-based system, which comprises a mycobacterial ...
Jessica C Seeliger +5 more
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Frontiers in Molecular Biosciences, 2022 Riboswitch RNAs regulate gene expression by conformational changes induced by environmental conditions and specific ligand binding. The guanidine-II riboswitch is proposed to bind the small molecule guanidinium and to subsequently form a kissing loop ...
Christin Fuks +4 more
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Cell, 2006 Riboswitches are common cis-acting regulatory elements in bacteria. They are made of nascent RNA that changes its conformation in response to direct binding of cognate metabolites. The publication of five high-resolution crystal structures provides a comprehensive view of how riboswitches sense their ligands and points to new challenges in this ...
openaire +2 more sources
Riboswitch finder--a tool for identification of riboswitch RNAs [PDF]
Nucleic Acids Research, 2004 We describe a dedicated RNA motif search program and web server to identify RNA riboswitches. The Riboswitch finder analyses a given sequence using the web interface, checks specific sequence elements and secondary structure, calculates and displays the energy folding of the RNA structure and runs a number of tests including this information to ...
Bengert, P., Dandekar, T.
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Translational gene expression control in Chlamydia trachomatis.
PLoS ONE, 2022 The human pathogen Chlamydia trachomatis proceeds through a multi phenotypic developmental cycle with each cell form specialized for different roles in pathogenesis.
Nicole A Grieshaber +5 more
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A transient conformation facilitates ligand binding to the adenine riboswitch
iScience, 2021 Summary: RNAs adopt various conformations to perform different functions in cells. Incapable of acquiring intermediates, the key initiations of ligand recognition in the adenine riboswitch have not been characterized.
Lin Wu, Dian Chen, Jienyu Ding, Yu Liu
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Magnesium ions mediate ligand binding and conformational transition of the SAM/SAH riboswitch
Communications Biology, 2023 The SAM/SAH riboswitch binds S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) with similar affinities. Mg2+ is generally known to stabilize RNA structures by neutralizing phosphates, but how it contributes to ligand binding and conformational ...
Guodong Hu, Huan-Xiang Zhou
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iScience, 2023 Summary: Metabolic homeostasis is regulated by enzyme activities, but the importance of regulating their corresponding coenzyme levels is unexplored. The organic coenzyme thiamine diphosphate (TDP) is suggested to be supplied as needed and controlled by ...
Zeenat Noordally +6 more
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