Results 31 to 40 of about 12,203 (191)
Architectures and complex functions of tandem riboswitches
RNA Biology, 2022 Riboswitch architectures that involve the binding of a single ligand to a single RNA aptamer domain result in ordinary dose-response curves that require approximately a 100-fold change in ligand concentration to cover nearly the full dynamic range for ...
Madeline E. Sherlock +14 more
doaj +1 more source
Classification of Riboswitch Families Using Block Location-Based Feature Extraction (BLBFE) Method [PDF]
Advanced Pharmaceutical Bulletin, 2020 Purpose: Riboswitches are special non-coding sequences usually located in mRNAs’ un-translated regions and regulate gene expression and consequently cellular function. Furthermore, their interaction with antibiotics has been recently implicated.
Faegheh Golabi +4 more
doaj +1 more source
Toward eradication of B-vitamin deficiencies : considerations for crop biofortification [PDF]
, 2018 'Hidden hunger' involves insufficient intake of micronutrients and is estimated to affect over two billion people on a global scale. Malnutrition of vitamins and minerals is known to cause an alarming number of casualties, even in the developed world ...
Strobbe, Simon +1 more
core +3 more sources
PLoS ONE, 2020 Riboswitches, generally located in the 5'-leader of bacterial mRNAs, direct expression via a small molecule-dependent structural switch that informs the transcriptional or translational machinery.
Lea K Drogalis, Robert T Batey
doaj +1 more source
Microbiology Spectrum, 2022 The trace metal manganese in excess affects iron-sulfur cluster and heme-protein biogenesis, eliciting cellular toxicity. The manganese efflux protein MntP is crucial to evading manganese toxicity in bacteria.
Arunima Kalita +4 more
doaj +1 more source
BMC Research Notes, 2018 Objective The purpose of this project was to use an in vivo method to discover riboswitches that are activated by new ligands. We employed phage-assisted continuous evolution (PACE) to evolve new riboswitches in vivo.
Zachary M. Shaver +30 more
doaj +1 more source
Comparative study between transcriptionally- and translationally-acting adenine riboswitches reveals key differences in riboswitch regulatory mechanisms. [PDF]
PLoS Genetics, 2011 Many bacterial mRNAs are regulated at the transcriptional or translational level by ligand-binding elements called riboswitches. Although they both bind adenine, the adenine riboswitches of Bacillus subtilis and Vibrio vulnificus differ by controlling ...
Jean-François Lemay +7 more
doaj +1 more source
The Distinctive Regulation of Cyanobacterial Glutamine Synthetase [PDF]
, 2018 Glutamine synthetase (GS) features prominently in bacterial nitrogen assimilation as it catalyzes the entry of bioavailable nitrogen in form of ammonium into cellular metabolism. The classic example, the comprehensively characterized GS of enterobacteria,
Bolay, Paul +3 more
core +1 more source
The Conserved Dcw Gene Cluster of R. sphaeroides Is Preceded by an Uncommonly Extended 5 Leader Featuring the sRNA UpsM [PDF]
, 2016 Cell division and cell wall synthesis mechanisms are similarly conserved among bacteria. Consequently some bacterial species have comparable sets of genes organized in the dcw (division and cell wall) gene cluster.
Klug, Gabriele +5 more
core +3 more sources
Engineering ligand-responsive RNA controllers in yeast through the assembly of RNase III tuning modules [PDF]
, 2011 The programming of cellular networks to achieve new biological functions depends on the development of genetic tools that link the presence of a molecular signal to gene-regulatory activity.
An +37 more
core +3 more sources