Results 71 to 80 of about 12,203 (191)
Riboswitch diversity and distribution [PDF]
RNA, 2017 Riboswitches are commonly used by bacteria to detect a variety of metabolites and ions to regulate gene expression. To date, nearly 40 different classes of riboswitches have been discovered, experimentally validated, and modeled at atomic resolution in complex with their cognate ligands.
Phillip J. McCown +4 more
openaire +2 more sources
Plant Biotechnology Journal, EarlyView.ABSTRACT Vitamin B1 (VB1) plays a crucial role in sustaining plant health and enabling adaptive responses to environmental stress. The complex maize genome implies a sophisticated VB1 synthesis pathway, with the mechanisms by which VB1 benefits plants remaining elusive.
Tengfei Zhang +8 more
wiley +1 more source
RNA folding kinetics control riboswitch sensitivity in vivo
Nature CommunicationsRiboswitches are ligand-responsive gene-regulatory RNA elements that perform key roles in maintaining cellular homeostasis. Understanding how riboswitch sensitivity to ligand (EC50) is controlled is critical to explain how highly conserved aptamer ...
David Z. Bushhouse +2 more
doaj +1 more source
Using a Riboswitch Sensor to Detect Co2+/Ni2+ Transport in E. coli
Frontiers in Chemistry, 2021 Intracellular concentrations of essential mental ions must be tightly maintained to avoid metal deprivation and toxicity. However, their levels in cells are still difficult to monitor. In this report, the combination of a Co2+Ni2+-specific riboswitch and
Xiaoying Wang +3 more
doaj +1 more source
PATTERNA: transcriptome-wide search for functional RNA elements via structural data signatures. [PDF]
, 2018 Establishing a link between RNA structure and function remains a great challenge in RNA biology. The emergence of high-throughput structure profiling experiments is revolutionizing our ability to decipher structure, yet principled approaches for ...
Aviran, Sharon, Ledda, Mirko
core
Evaluating riboswitch optimality
, 2019 Riboswitches are RNA elements that recognize diverse chemical and biomolecular inputs, and transduce this recognition process to genetic, fluorescent, and other engineered outputs using RNA conformational changes. These systems are pervasive in cellular biology and are a promising biotechnology with applications in genetic regulation and biosensing ...
Hannah, Wayment-Steele +3 more
openaire +3 more sources
Singlet glycine riboswitches bind ligand as well as tandem riboswitches [PDF]
RNA, 2016 The glycine riboswitch often occurs in a tandem architecture, with two ligand-binding domains (aptamers) followed by a single expression platform. Based on previous observations, we hypothesized that “singlet” versions of the glycine riboswitch, which contain only one aptamer domain, are able to bind glycine if appropriate structural contacts are ...
Ruff, Karen M. +4 more
openaire +2 more sources
Plastid Engineering for Photosynthesis‐Driven Synthesis of Hyaluronic Acid in Tobacco
Plant Biotechnology Journal, EarlyView.ABSTRACT Hyaluronic acid (HA) is a glycosaminoglycan composed of alternating units of N‐acetylglucosamine and glucuronic acid. High moisture retention, viscoelasticity and biocompatibility are unique features that make HA polymers attractive compounds for medical applications and aesthetic purposes.
Amanda Lopes +10 more
wiley +1 more source
Nature Communications, 2023 Cell-free genetically encoded biosensors have been developed to detect small molecules and nucleic acids, but they have yet to be reliably engineered to detect proteins.
Grace E. Vezeau +2 more
doaj +1 more source
Thiamine Acquisition Strategies Impact Metabolism and Competition in the Gut Microbe Bacteroides thetaiotaomicron. [PDF]
, 2017 Thiamine (vitamin B1) is an essential cofactor for all organisms. Humans primarily acquire thiamine through their diet, and thiamine deficiencies have adverse neurological effects.
Costliow, Zachary A, Degnan, Patrick H
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