Results 81 to 90 of about 12,203 (191)
Selecting RNA aptamers for synthetic biology: investigating magnesium dependence and predicting binding affinity. [PDF]
, 2010 The ability to generate RNA aptamers for synthetic biology using in vitro selection depends on the informational complexity (IC) needed to specify functional structures that bind target ligands with desired affinities in physiological concentrations of ...
Carothers, James M +4 more
core +2 more sources
A Decade of Riboswitches [PDF]
Cell, 2013 Riboswitches were discovered in 2002 in bacteria as RNA-based intracellular sensors of vitamin derivatives. During the last decade, naturally occurring RNA sensor elements have been found to bind a range of small metabolites and ions and to exert regulatory control of transcription, translation, splicing, and RNA stability.
Serganov, Alexander, Nudler, Evgeny
openaire +2 more sources
Statistical modeling of RNA structure profiling experiments enables parsimonious reconstruction of structure landscapes. [PDF]
, 2018 RNA plays key regulatory roles in diverse cellular processes, where its functionality often derives from folding into and converting between structures.
Aviran, Sharon, Li, Hua
core +2 more sources
Human gut Bacteroides capture vitamin B12 via cell surface-exposed lipoproteins. [PDF]
, 2018 Human gut Bacteroides use surface-exposed lipoproteins to bind and metabolize complex polysaccharides. Although vitamins and other nutrients are also essential for commensal fitness, much less is known about how commensal bacteria compete with each other
Barry, Natasha A +5 more
core
, 2014 RNA molecules are essential cellular machines performing a wide variety of functions for which a specific three-dimensional structure is required. Over the last several years, experimental determination of RNA structures through X-ray crystallography and
Cragnolini, Tristan +2 more
core +1 more source
Subinhibitory concentrations of trimethoprim and sulfamethoxazole prevent biofilm formation by Acinetobacter baumannii through inhibition of Csu pilus expression [PDF]
, 2017 Acinetobacter baumannii is emerging as a multidrug-resistant nosocomial pathogen of increasing threat to human health worldwide. Pili are important bacterial virulence factors, playing a role in attachment to host cells and biofilm formation.
Feldman, Mario F +2 more
core +2 more sources
Reversing Antibiotic Resistance: Strategies From Adjuvants to Innovative Therapeutics
MicrobiologyOpen, Volume 15, Issue 1, February 2026.Molecular reversal strategies against antibiotic resistance act through three mechanisms: inhibiting resistance gene function, blocking horizontal gene transfer, and modulating host defense. Emerging technologies, such as CRISPR‐Cas gene editing, photodynamic therapy, nanotechnology, and ecological competition, further strengthen these approaches ...
Tianjiao Li +4 more
wiley +1 more source
Synthesis of O6-alkylated preQ1 derivatives
Beilstein Journal of Organic Chemistry, 2021 A naturally occurring riboswitch can utilize 7-aminomethyl-O6-methyl-7-deazaguanine (m6preQ1) as cofactor for methyl group transfer resulting in cytosine methylation.
Laurin Flemmich +2 more
doaj +1 more source
A Synthetic Riboswitch to Regulate Haloarchaeal Gene Expression
Frontiers in Microbiology, 2021 In recent years, synthetic riboswitches have become increasingly important to construct genetic circuits in all three domains of life. In bacteria, synthetic translational riboswitches are often employed that modulate gene expression by masking the Shine-
Johannes Born +4 more
doaj +1 more source
Postepy biochemii, 2005 Riboswitches are RNA structures able to bind small molecules and regulate gene expression at both, transcriptional and translational level. They are present in a wide variety of bacterial species. In Bacillus subtilis more than 2% of the genome is regulated by riboswitches. Metabolite binding is highly specific and can be provided in cooperative manner.
Katarzyna, Bugała +4 more
openaire +1 more source