Results 101 to 110 of about 28,198 (287)
A Ribozyme for the Aldol Reaction [PDF]
Chemistry & Biology, 2005 Directed in vitro evolution can create RNA catalysts for a variety of organic reactions, supporting the "RNA world" hypothesis, which proposes that metabolic transformations in early life were catalyzed by RNA molecules rather than proteins. Among the most fundamental carbon-carbon bond-forming reactions in nature is the aldol reaction, mainly ...
Alexander Eisenführ +4 more
openaire +3 more sources
Ribozyme-Spherical Nucleic Acids.
Journal of the American Chemical Society, 2015 Ribozymes are highly structured RNA sequences that can be tailored to recognize and cleave specific stretches of mRNA. Their current therapeutic efficacy remains low due to their large size and structural instability compared to shorter therapeutically ...
J. Rouge +6 more
semanticscholar +1 more source
RNAi technology development for weed control: all smoke and no fire?
Pest Management Science, EarlyView.Despite the potential of Spray‐Induced Gene Silencing in weed management several critical points such as molecular target, weed species of interest as well as delivery techniques need to be addressed. Abstract RNA interference (RNAi) technology, specifically Spray‐Induced Gene Silencing (SIGS), holds potential as an innovative approach for selective ...
Silvia Panozzo +4 more
wiley +1 more source
Nucleic Acid‐Modified Nanoparticles for Cancer Therapeutic Applications
Small, EarlyView.Nucleic acid‐modified nanoparticles act as functional hybrids for chemodynamic, photodynamic, photothermal, and gene therapy of cancer cells. These are exemplified with aptamer‐modified catalytic nanoparticles, photosensitizer‐oligonucleotide functionalized nanoparticles, drug‐loaded stimuli‐responsive nucleic acid‐caged nanoparticle carriers, and ...
Yunlong Qin +2 more
wiley +1 more source
Iterative Annealing Mechanism Explains the Functions of the GroEL and RNA Chaperones [PDF]
arXiv, 2019 Molecular chaperones are ATP-consuming biological machines, which facilitate the folding of proteins and RNA molecules that are kinetically trapped in misfolded states for long times. Unassisted folding occurs by the kinetic partitioning mechanism according to which folding to the native state, with low probability as well as misfolding to one of the ...
arxiv
Rapid Amplification and Detection of Single‐Stranded Nucleic Acids for Point‐of‐Care Diagnosis
Small Methods, EarlyView.A rapid, point‐of‐care nucleic acid test can greatly benefit healthcare system by providing timely diagnosis for effective treatment and patient management, as well as supporting diseases surveillance for emerging pandemic diseases. Recent advancements in nucleic acids technology have led to rapid assays for single‐stranded nucleic acids that can be ...
Jinglin Fu +6 more
wiley +1 more source
Pathways and kinetic barriers in mechanical unfolding and refolding of RNA and proteins [PDF]
Structure (2006) vol 14. 1633-1645, 2006 Using self-organized polymer models, we predict mechanical unfolding and refolding pathways of ribo-zymes, and the green fluorescent protein. In agreement with experiments, there are between six and eight unfolding transitions in the Tetrahymena ribozyme.
arxiv
Cryo-EM structures of full-length Tetrahymena ribozyme at 3.1 Å resolution
Nature, 2021 Z. Su +10 more
semanticscholar +1 more source
Molecular Microbiology, Volume 123, Issue 4, Page 330-343, April 2025.In silico workflow for selection of genes targeted in this study. We have identified a number of proteins involved in host cell modification by malaria parasites. Furthermore, we highlight a number of genes that appear to be essential for blood‐stage survival of these parasites.
Nina Küster +4 more
wiley +1 more source
Thermodynamics of the Hairpin Ribozyme from All-Atom Simulations [PDF]
arXiv, 2006 The structure of the self-cleaving hairpin ribozyme is well characterized, and its folding has been examined in bulk and by single-molecule fluorescence, establishing the importance of cations, especially magnesium in the stability of the native fold. Here we describe the first all-atom folding simulations of the hairpin ribozyme, using a version of a ...
arxiv