Ribozyme - Open Access .click

Results 131 to 140 of about 12,837 (178)

Some of the next articles are maybe not open access.

Biopolymers, 1999
The hammerhead ribozyme is an intriguing RNA molecule with the ability to serve as a catalyst to cleave sequence-specifically RNA molecules in an intermolecular reaction. Preferentially Mg(2+) is required for optimal activity by inducing the catalytically competent conformation and by possibly acting as an acid-base catalyst.
F, Eckstein, B, Bramlage
openaire +2 more sources

Ribozymes in Wonderland

Science, 1997
Robertson, Michael P. Bull, Jim On p. [614][1] of this issue, Wright and Joyce report the successful evolution of a catalytic ribozyme selected for its ability to perform ligation. In their Perspective, Ellington et al . comment on the advances in this study over previous efforts and what this work tells us about evolution.
A D, Ellington, M P, Robertson, J, Bull
openaire +2 more sources

Cytotoxic Hammerhead Ribozymes

Antisense and Nucleic Acid Drug Development, 1999
Small catalytic RNA molecules of the hammerhead ribozyme type were found to have cytotoxic effects unrelated to their intended activity. An expression library of ribozyme sequence variants was constructed in a recA-deficient strain of Escherichia coli such that individual library members differed in regions designed to form base pairs with human ...
R, Levitz +9 more
openaire +2 more sources

Ribozymes