Results 91 to 100 of about 25,371 (268)
Advanced Science, Volume 13, Issue 3, 14 January 2026.A cell‐mimetic hydrogel compartment is proposed to enhance the efficiency of enzymatic reactions. The naturally porous structure of a crowded hydrogel can simulate the intracellular microenvironment, promoting the aggregation of biomolecules and activity of DNA polymerase through excluded volume effects and compartmentalization.
Fangbin Xiao +3 more
wiley +1 more source
, 2009 Ribozimi su katalitičke molekule koje moraju biti savijene u visoko uređene tercijarne strukture, kao što to proteini rade da bi obavljali svoje funkcije. Glavni cilj je dovesti nukleofil i izrezujući fosfat u blizinu i aktivirati ih.
Zoko, Nikolina
core +2 more sources
Molecular Therapy: Nucleic Acids, 2013 Target substrate-specific hammerhead ribozyme cleaves the specific mRNA efficiently and results in the inhibition of gene expression. In humans, overproduction of apolipoprotein B (apoB) is positively associated with premature coronary artery diseases ...
Hersharan Nischal +6 more
doaj +1 more source
High‐Efficiency Genome Editing of Chlorella sp. by CRISPR/Cas9
Plant Biotechnology Journal, EarlyView.
Xinyu Cui +5 more
wiley +1 more source
ChemMedChem, Volume 21, Issue 1, January 2026.Investigation of the structure‐activity relationship on W482 (1) with a pyrimidine‐2,4‐diamine scaffold culminated in analog 51 with enhanced anti‐plasmodial activity. Forward genetics and phenotypic examination revealed the ABCI3 transporter protein as a putative resistance mechanism.
Mahta Mansouri +14 more
wiley +1 more source
Large Phenotypic Enhancement of Structured Random RNA Pools. [PDF]
, 2020 Laboratory evolution of functional RNAs has applications in many areas of chemical and synthetic biology. In vitro selections critically depend on the presence of functional molecules, such as aptamers and ribozymes, in the starting sequence pools.
Chizzolini, Fabio +5 more
core
Facile synthesis of a 3-deazaadenosine phosphoramidite for RNA solid-phase synthesis
Beilstein Journal of Organic Chemistry, 2016 Access to 3-deazaadenosine (c3A) building blocks for RNA solid-phase synthesis represents a severe bottleneck in modern RNA research, in particular for atomic mutagenesis experiments to explore mechanistic aspects of ribozyme catalysis.
Elisabeth Mairhofer +2 more
doaj +1 more source
Discovery of Viroids and Viroid‐Like RNAs in Plants
Plant Biotechnology Journal, EarlyView.
Zhiyou Xuan +15 more
wiley +1 more source
Updates to the CASP Infrastructure in 2024
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 1, Page 15-24, January 2026.ABSTRACT CASP (critical assessment of structure prediction) conducts community experiments to determine the state of the art in calculating macromolecular structures. The CASP data management system is continually evolving to address the changing needs of the experiments.
Andriy Kryshtafovych +6 more
wiley +1 more source