Biology, 2016 Group I self-splicing intron constitutes an important class of functional RNA molecules that can promote chemical transformation. Although the fundamental mechanism of the auto-excision from its precursor RNA has been established, convenient assay ...
Airi Furukawa +4 more
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Controlled evolution of an RNA enzyme [PDF]
It is generally thought that prior to the origin of protein synthesis, life on earth was based on self-replicating RNA molecules. This idea has become especially popular recently due to the discovery of catalytic RNA (ribozymes).
Joyce, G. F.
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Can hammerhead ribozymes be efficient tools to inactivate gene function? [PDF]
, 1994 Édouard Bertrand +2 more
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Viroids and Retrozymes: Plant Circular RNAs Capable of Autonomous Replication
PlantsAmong the long non-coding RNAs that are currently recognized as important regulatory molecules influencing a plethora of processes in eukaryotic cells, circular RNAs (circRNAs) represent a distinct class of RNAs that are predominantly produced by back ...
Alexander A. Lezzhov +5 more
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Aptamers in oncology: a diagnostic perspective [PDF]
, 2008 Nucleic acid sequences can produce a wide variety of three-dimensional conformations. Some of these structural forms are able to interact with proteins and small molecules with high affinity and specificity.
Khan, Huma, Missailidis, Sotiris
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Synthesis of circular RNA in bacteria and yeast using RNA cyclase ribozymes derived from a group I intron of phage T4. [PDF]
, 1994 E. Ford, Manuel Ares
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T. thermophila group I introns that cleave amide bonds [PDF]
, 1997 The present invention relates to nucleic acid enzymes or enzymatic RNA molecules that are capable of cleaving a variety of bonds, including phosphodiester bonds and amide bonds, in a variety of substrates.
Joyce, Gerald F.
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Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion. [PDF]
, 1994 Shimon Efrat +9 more
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Facile synthesis of a 3-deazaadenosine phosphoramidite for RNA solid-phase synthesis
Beilstein Journal of Organic Chemistry, 2016 Access to 3-deazaadenosine (c3A) building blocks for RNA solid-phase synthesis represents a severe bottleneck in modern RNA research, in particular for atomic mutagenesis experiments to explore mechanistic aspects of ribozyme catalysis.
Elisabeth Mairhofer +2 more
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Influence of a fluorobenzene nucleobase analogue on the conformational flexibility of RNA studied by molecular dynamics simulations [PDF]
, 2006 Chemically modified bases are frequently used to stabilize nucleic acids, to study the driving forces for nucleic acid structure formation and to tune DNA and RNA hybridization conditions.
Engels, Joachim W. (Prof. Dr.) +1 more
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