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An Engineered RNase P Ribozyme Effectively Reduces Human Coronavirus 229E Gene Expression and Growth in Human Cells

open access: yesZoonotic Diseases
The human coronavirus 229E (HCoV-229E) is a member of the human coronavirus family that includes SARS-CoV-2, the causative agent of COVID-19. Developing antiviral strategies and compounds is crucial to treat and prevent HCoV-229E infections and the ...
Yujun Liu   +3 more
doaj   +1 more source

Ribozymes, recognition and evolution

open access: yesChemistry & Biology, 1995
Precision in the recognition and orientation of substrate is important in the selectivity of catalysis by natural enzymes. Several new ribozyme species have been evolved using in vitro selection/mutagenesis which make use of precise substrate recognition to catalyze a variety of reactions.
openaire   +3 more sources

Self-cleavage activity of the genomic HDV ribozyme in the presence of various divalent metal ions [PDF]

open access: green, 1993
Young‐Ah Suh   +3 more
openalex   +1 more source

Ribozymes [PDF]

open access: yesCurrent Biology, 1998
openaire   +1 more source

Mutagenesis of the hairpin ribozyme [PDF]

open access: green, 1994
Pamela J. Anderson   +5 more
openalex   +1 more source

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