Results 11 to 20 of about 25,371 (268)

RNase P Ribozymes Inhibit the Replication of Human Cytomegalovirus by Targeting Essential Viral Capsid Proteins [PDF]

, 2015
An engineered RNase P-based ribozyme variant, which was generated using the in vitro selection procedure, was used to target the overlapping mRNA region of two proteins essential for human cytomegalovirus (HCMV) replication: capsid assembly protein (AP ...
Zhu Yang, Michael A. Reeves, Jun Ye, Phong Trang, Li Zhu, Jingxue Sheng, Yu Wang, Ke Zen, Jianguo Wu, Fenyong Liu   +9 more
openalex   +6 more sources

Evolution of the division of labor between genes and enzymes in the RNA world. [PDF]

PLoS Computational Biology, 2014
The RNA world is a very likely interim stage of the evolution after the first replicators and before the advent of the genetic code and translated proteins.
Gergely Boza, András Szilágyi, Ádám Kun, Mauro Santos, Eörs Szathmáry   +4 more
doaj   +6 more sources

Identification of HDV-like theta ribozymes involved in tRNA-based recoding of gut bacteriophages [PDF]

Nature Communications
Trillions of microorganisms, collectively known as the microbiome, inhabit our bodies with the gut microbiome being of particular interest in biomedical research. Bacteriophages, the dominant virome constituents, can utilize suppressor tRNAs to switch to
Kasimir Kienbeck, Lukas Malfertheiner, Susann Zelger-Paulus, Silke Johannsen, Christian von Mering, Roland K. O. Sigel   +5 more
doaj   +2 more sources

RNA ligase ribozymes with a small catalytic core

Scientific Reports, 2023
Catalytic RNAs, or ribozymes, catalyze diverse chemical reactions that could have sustained primordial life in the hypothetical RNA world. Many natural ribozymes and laboratory evolved ribozymes exhibit efficient catalysis mediated by elaborate catalytic
Yoko Nomura, Yohei Yokobayashi
doaj   +1 more source

Aptamers, Riboswitches, and Ribozymes in S. cerevisiae Synthetic Biology

Life, 2021
Among noncoding RNA sequences, riboswitches and ribozymes have attracted the attention of the synthetic biology community as circuit components for translation regulation.
Huanhuan Ge, Mario Andrea Marchisio
doaj   +1 more source

A hammerhead ribozyme selects mechanically stable conformations for catalysis against viral RNA. [PDF]

Commun Biol
Lu M, Cao Z, Xiong L, Deng H, Ma K, Liu N, Qin Y, Chen SB, Chen JH, Li Y, Liu Y, Yu Z.   +11 more
europepmc   +2 more sources

Oligonucleotide-Based Approaches to Inhibit Dengue Virus Replication

Molecules, 2021
Dengue fever is one of the most common viral infections affecting humans. It is an expanding public health problem, particularly in tropical and subtropical regions.
Kingshuk Panda, Kalichamy Alagarasu, Deepti Parashar   +2 more
doaj   +1 more source

Ribozymes [PDF]

Current Opinion in Structural Biology, 2007
The structural molecular biology of ribozymes took another great leap forward during the past two years. Before ribozymes were discovered in the early 1980s, all enzymes were thought to be proteins. No detailed structural information on ribozymes became available until 1994.
openaire   +3 more sources

Ribozyme Therapeutics [PDF]

Journal of Investigative Dermatology Symposium Proceedings, 2002
Since their initial discovery, ribozymes have shown great promise not just as a tool in the manipulation of gene expression, but also as a novel therapeutic agent. This review discusses the promises and pitfalls of ribozyme technology, with a special emphasis on cancer-related applications, though relevance to skin disease will also be discussed.
openaire   +2 more sources

Biochemical prevention and treatment of viral infections – A new paradigm in medicine for infectious diseases [PDF]

, 2004
For two centuries, vaccination has been the dominating approach to develop prophylaxis against viral infections through immunological prevention. However, vaccines are not always possible to make, are ineffective for many viral infections, and also carry
Fang, Fang, Le Calvez, Hervé, Yu, Mang
core   +3 more sources