Results 251 to 260 of about 34,904 (304)
Ribozymes, riboswitches and beyond: regulation of gene expression without proteins
Nature Reviews Genetics, 2007 Alexander Serganov
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Ribozyme-Catalyzed Transcription of an Active Ribozyme
Science, 2011A functional RNA has been synthesized by an RNA enzyme from mononucleotide building blocks.
James Attwater +3 more
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Science, 1997
Robertson, Michael P. Bull, Jim On p. [614][1] of this issue, Wright and Joyce report the successful evolution of a catalytic ribozyme selected for its ability to perform ligation. In their Perspective, Ellington et al . comment on the advances in this study over previous efforts and what this work tells us about evolution.
Andrew D. Ellington +2 more
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Robertson, Michael P. Bull, Jim On p. [614][1] of this issue, Wright and Joyce report the successful evolution of a catalytic ribozyme selected for its ability to perform ligation. In their Perspective, Ellington et al . comment on the advances in this study over previous efforts and what this work tells us about evolution.
Andrew D. Ellington +2 more
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The chemical repertoire of natural ribozymes
Nature, 2002Jennifer A Doudna, Thomas R Cech
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Biochemical Society Transactions, 2002
The hammerhead ribozyme is a small RNA motif consisting of three helices that intersect at a conserved core. When correctly folded, the hammerhead ribozyme stimulates nearly complete cleavage of the phosphodiester chain at a defined internal site to give 2′,3′-cyclic and 5′-hydroxy termini. The cleavage rate is approx.
Olke C. Uhlenbeck, Kenneth F. Blount
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The hammerhead ribozyme is a small RNA motif consisting of three helices that intersect at a conserved core. When correctly folded, the hammerhead ribozyme stimulates nearly complete cleavage of the phosphodiester chain at a defined internal site to give 2′,3′-cyclic and 5′-hydroxy termini. The cleavage rate is approx.
Olke C. Uhlenbeck, Kenneth F. Blount
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Ribozymes: the hairpin and Varkud ribozymes are related.
Rivista di biologia, 2003The hairpin ribozyme of plant virusoids and the Varkud ribozyme from a retroplasmid of fungal mitochondria show notable similarities in sequence and secondary structure. Some more distant inter-relationships appear to exist between this pair, the viroid/virusoid hammerhead and the hepatitis delta ribozyme.
David Elder, Ray J. Harris
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Current Opinion in Biotechnology, 1992
RNA enzymes or ribozymes are receiving considerable attention for their potential use as highly specific inhibitors of gene expression. From the basic science perspective, the mechanisms by which ribozymes catalyze site-specific cleavage (and in some cases ligation) reactions provide exciting and active areas of scientific investigation.
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RNA enzymes or ribozymes are receiving considerable attention for their potential use as highly specific inhibitors of gene expression. From the basic science perspective, the mechanisms by which ribozymes catalyze site-specific cleavage (and in some cases ligation) reactions provide exciting and active areas of scientific investigation.
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Conditional control of mammalian gene expression by tetracycline-dependent hammerhead ribozymes.
ACS Synthetic Biology, 2015Robust synthetic devices are requisite for the construction of synthetic genetic circuits and important scientific and technological tools to control cellular processes.
Kim Beilstein +3 more
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Molecular and Cellular Neuroscience, 1998
The selective inactivation of genes, in a tissue-specific or temporally controlled manner, is now an important requirement for the analysis of nervous system development and function. Hammerhead ribozymes--catalytic RNA enzymes that specifically bind to and then cleave target RNAs--may provide a way to meet this requirement, particularly for organisms ...
Jack Jiagang Zhao, Greg Lemke
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The selective inactivation of genes, in a tissue-specific or temporally controlled manner, is now an important requirement for the analysis of nervous system development and function. Hammerhead ribozymes--catalytic RNA enzymes that specifically bind to and then cleave target RNAs--may provide a way to meet this requirement, particularly for organisms ...
Jack Jiagang Zhao, Greg Lemke
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Biopolymers, 1998
In this review I will outline several chemogenetic approaches used to determine the chemical basis of large ribozyme function and structure. The term chemogenetics was first used to describe site-specific functional group modification experiments in the analysis of DNA-protein interactions.
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In this review I will outline several chemogenetic approaches used to determine the chemical basis of large ribozyme function and structure. The term chemogenetics was first used to describe site-specific functional group modification experiments in the analysis of DNA-protein interactions.
openaire +2 more sources