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The Ribosome Functions as a Ribozyme
ChemBioChem, 2001One of the most exciting developments in biological chemistry in the last two decades has been the discovery that RNA can catalyse chemical reactions. This is no longer the sole preserve of protein-based enzymes, and raises the intriguing possibility that in the early appearance of life on this planet it may have passed through a phase in which RNA ...
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2006
The self-cleaving RNA sequences, or ribozymes, in the genomic and antigenomic strands of hepatitis delta virus (HDV) RNA fold into structures that are similar to each other but distinct from those of small ribozymes associated with the RNA replicons that infect plants.
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The self-cleaving RNA sequences, or ribozymes, in the genomic and antigenomic strands of hepatitis delta virus (HDV) RNA fold into structures that are similar to each other but distinct from those of small ribozymes associated with the RNA replicons that infect plants.
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Intracellular ribozyme applications
Biochemical Society Transactions, 2002The exquisite target selectivity of trans-acting ribozymes has fostered their use as potential therapeutic agents and tools for down-regulating cellular transcripts. In living cells, free diffusion of RNAs is extremely limited, if it exists at all.
Castanotto, D +6 more
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Molecular Biosystems, 2011
Synthetic regulatory devices are key components for the development of complex biological systems and the reprogramming of cellular functions and networks. Here we describe the selection of tetracycline inducible hammerhead ribozymes.
Alexander Wittmann, B. Suess
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Synthetic regulatory devices are key components for the development of complex biological systems and the reprogramming of cellular functions and networks. Here we describe the selection of tetracycline inducible hammerhead ribozymes.
Alexander Wittmann, B. Suess
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Molecular Medicine Today, 1998
Abstract Ribozyme-mediated trans -splicing of a trinucleotide repeat Phylactou, L.A., Darrah, C. and Wood, M.J.A. (1998) Nat. Genet.
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Abstract Ribozyme-mediated trans -splicing of a trinucleotide repeat Phylactou, L.A., Darrah, C. and Wood, M.J.A. (1998) Nat. Genet.
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Ribozymes and Their Medical Implications
JAMA: The Journal of the American Medical Association, 1988Certain RNA molecules can mediate their own cleavage or splicing or act as enzymes to promote reactions on substrate RNA molecules. Thus, RNA is not restricted to being a passive carrier of genetic information but can have an active role in directing cellular biochemistry.
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Ribozymes and the mechanisms that underlie RNA catalysis
Frontiers of Chemical Science and Engineering, 2016T. J. Wilson, Yanjun Liu, D. Lilley
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