Results 31 to 40 of about 34,904 (304)
Novel ribozymes: discovery, catalytic mechanisms, and the quest to understand biological function
Nucleic Acids Research, 2019 Small endonucleolytic ribozymes promote the self-cleavage of their own phosphodiester backbone at a specific linkage. The structures of and the reactions catalysed by members of individual families have been studied in great detail in the past decades ...
Christin Weinberg +2 more
semanticscholar +1 more source
Induction of ribozyme activity by anti-ribozyme oligonucleotides [PDF]
Nucleic Acids Symposium Series, 1999 A new type of hammerhead ribozyme, with cleavage activity enhanced by oligonucleotides, was constructed. Stem II of the ribozyme was substituted with a non complementary loop (loop II). The modified ribozyme exhibited negligible cleavage of a target RNA; however, it was converted to an active molecule in the presence of oligonucleotides which were ...
Nobuhiro Kazama +3 more
openaire +3 more sources
The Origin of Life: Models and Data. [PDF]
, 2017 A general framework for conventional models of the origin of life (OOL) is the specification of a 'privileged function.' A privileged function is an extant biological function that is excised from its biological context, elevated in importance over other
Lanier, Kathryn A, Williams, Loren Dean
core +1 more source
Investigating a new generation of ribozymes in order to target HCV.
PLoS ONE, 2010 For a long time nucleic acid-based approaches directed towards controlling the propagation of Hepatitis C Virus (HCV) have been considered to possess high potential. Towards this end, ribozymes (i.e.
Michel V Lévesque +3 more
doaj +1 more source
Journal of Investigative Dermatology Symposium Proceedings, 2002 Since their initial discovery, ribozymes have shown great promise not just as a tool in the manipulation of gene expression, but also as a novel therapeutic agent. This review discusses the promises and pitfalls of ribozyme technology, with a special emphasis on cancer-related applications, though relevance to skin disease will also be discussed.
openaire +2 more sources
Comparison of the Structures and Mechanisms of the Pistol and Hammerhead Ribozymes
Journal of the American Chemical Society, 2019 Comparison of the secondary and three-dimensional structures of the hammerhead and pistol ribozymes reveals many close similarities, so in this work we have asked if they are mechanistically identical.
T. J. Wilson +5 more
semanticscholar +1 more source
The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA. [PDF]
, 2011 In the early 'RNA world' stage of life, RNA stored genetic information and catalyzed chemical reactions. However, the RNA world eventually gave rise to the DNA-RNA-protein world, and this transition included the 'genetic takeover' of information storage ...
Chen, Irene A +4 more
core +4 more sources
B2 and ALU retrotransposons are self-cleaving ribozymes whose activity is enhanced by EZH2
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Among the 15 known classes of ribozymes, only 3 occur in mammals, and 6 are self-cleaving. Their physiological functions are mostly unclear. Here, we link a ribozyme activity to the stress response in mammals.
Alfredo J. Hernandez +5 more
semanticscholar +1 more source
A new view of RNA: the 1989 discovery by Sidney Altman and Thomas Cech [PDF]
The Ukrainian Biochemical Journal, 2020 The 1989 Nobel Prize Laureates in Chemistry Sidney Altman and Thomas Robert Cech made one of the most important discoveries in molecular genetics. Independently of each other, they demonstrated new experimental evidence that RNA molecules can not only ...
M. V. Grigorieva +2 more
doaj +1 more source
mSphere, 2020 The term “prion” was originally coined to describe the proteinaceous infectious agents involved in mammalian neurological disorders. More recently, a prion has been defined as a nonchromosomal, protein-based genetic element that is capable of converting ...
Arcady R. Mushegian, Santiago F. Elena
doaj +3 more sources