Results 41 to 50 of about 25,371 (268)
Life, 2018 One of the most intriguing questions in biological science is how life originated on Earth. A large number of hypotheses have been proposed to explain it, each putting an emphasis on different events leading to functional translation and self-sustained ...
Dimiter Kunnev, Anastas Gospodinov
doaj +1 more source
Ribozyme Activity of RNA Nonenzymatically Polymerized from 3′,5′-Cyclic GMP
Entropy, 2013 3′,5′-Cyclic GMP spontaneously nonenzymatically polymerizes in a base-catalyzed reaction affording G oligonucleotides. When reacted with fully or partially sequence-complementary RNA (oligo C), the abiotically generated oligo G RNA displays a typical ...
Samanta Pino +5 more
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A new view of RNA: the 1989 discovery by Sidney Altman and Thomas Cech [PDF]
The Ukrainian Biochemical Journal, 2020 The 1989 Nobel Prize Laureates in Chemistry Sidney Altman and Thomas Robert Cech made one of the most important discoveries in molecular genetics. Independently of each other, they demonstrated new experimental evidence that RNA molecules can not only ...
M. V. Grigorieva +2 more
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Advanced Functional Materials, EarlyView.We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj +21 more
wiley +1 more source
Processing of insect retrotransposons by self-cleaving ribozymes [PDF]
, 2010 We show that several classes of insect non-LTR retrotransposons harbor self-cleaving ribozymes of the HDV family at their 5′ termini. In Drosophila the R2 ribozymes exhibit highly differential in vivo expression and robust in vitro activity ...
Andrej Luptak +3 more
core +1 more source
Advanced Science, EarlyView.To precisely modulate natural and synthetic regulatory parts, SUPER is introduced as a sophisticated and tunable controller of genetic devices without requiring sequence modification on the target. SUPER enhances dynamic range of RNA‐, chemical‐, temperature‐, and protein‐responsive biosensors up to 1011%, and converts biosensors to cover an expanded ...
Taeyang Heo +3 more
wiley +1 more source
Meeting review : ESF workshop on "Impact of nucleic acid chemistry on gene function analysis: antisense, aptamers, ribozymes and RNAi" [PDF]
, 2008 The shortage of functional information compared to the abundance of sequence information characterizes today’s situation in functional genomics. For many years the knock-down of a gene’s product has been the most powerful way of analysing its function ...
Engels, Joachim W. (Prof. Dr.) +3 more
core
Hammerhead Ribozymes: True Metal or Nucleobase Catalysis? Where Is the Catalytic Power from?
Molecules, 2010 The hammerhead ribozyme was first considered as a metalloenzyme despite persistent inconsistencies between structural and functional data. In the last decade, metal ions were confirmed as catalysts in self-splicing ribozymes but displaced by nucleobases ...
Fabrice Leclerc
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IET Nanobiotechnology, 2022 After the outbreak of coronavirus disease 2019 (COVID‐19) in December 2019 and the increasing number of SARS‐CoV‐2 infections all over the world, researchers are struggling to investigate effective therapeutic strategies for the treatment of this ...
Seyedeh Hoda Alavizadeh +6 more
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Translation‐Promoting Effects of RNA Template Overhangs in the Absence of Ribosomes
Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.Ribosome‐free translation of an RNA sequence into a peptide sequence can be controlled by the folding of the template strand. Overhang sequences forming a triplex structure with the templating region and the peptidoyl RNA in pH‐dependent manner increase yields up to 40‐fold through entropic effects and mixed anhydride formation, allowing for controlled,
Nikolaos Giannakopoulos +2 more
wiley +2 more sources