The association of shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effect [PDF]
, 2006 Receptor-mediated internalization to the endoplasmic reticulum (ER) and subsequent retro-translocation to the cytosol are essential sequential processes required for the productive intoxication of susceptible mammalian cells by Shiga-like toxin-1 (SLTx).
Falguières, Thomas +7 more
core +3 more sources
Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis. [PDF]
, 2013 Oligodendrocytes associate with axons to establish myelin and provide metabolic support to neurons. In the spinal cord of amyotrophic lateral sclerosis (ALS) mice, oligodendrocytes downregulate transporters that transfer glycolytic substrates to neurons ...
Bergles, Dwight E +7 more
core +2 more sources
Membrane fusion mediated by ricin and viscumin [PDF]
, 1998 The ribosome inactivating plant proteins (RIPs) ricin and viscumin but not Ricinus communis agglutinin are able induce vesicle–vesicle fusion. A model is suggested in which the toxicity of the RIPs is partially determined by their fusogenicity.
Peter Pohl +39 more
core +1 more source
Toxic plants and companion animals. [PDF]
, 2009 Poisoning by substances of plant origin is unusual in both dogs and cats, yet it is possible; as many veterinarians do not know which plants can contain toxic active principles, the possibility of intoxication by ornamental plants commonly used to ...
SEVERINO, LORELLA
core +1 more source
Inhibitors of the Cellular Trafficking of Ricin
Toxins, 2012 Throughout the last decade, efforts to identify and develop effective inhibitors of the ricin toxin have focused on targeting its N-glycosidase activity.
Daniel Gillet +3 more
doaj +1 more source
Isolation and Characterization of Lectins from Ricinus communis [PDF]
, 2012 Lectins are proteins which are well distributed in nature. They are found in both plants and animals but plants are the richest source. On the surface of the cell lectins are attached with their sugar binding site. Lectins are found to be toxic, as it is
Bhoi, Archana
core
Bioaffinity detection of pathogens on surfaces [PDF]
, 2010 The demand for improved technologies capable of rapidly detecting pathogens with high sensitivity and selectivity in complex environments continues to be a significant challenge that helps drive the development of new analytical techniques. Surface-based
Faisal, S. N. +4 more
core +1 more source
Role of the Mannose Receptor (CD206) in Innate Immunity to Ricin Toxin
Toxins, 2011 The entry of ricin toxin into macrophages and certain other cell types in the spleen and liver results in toxin-induced inflammation, tissue damage and organ failure.
Emily Gage +4 more
doaj +1 more source
Selective destruction of nerve growth factor receptor-bearing cells in vitro using a hybrid toxin composed of ricin A chain and a monoclonal antibody against the nerve growth factor receptor. [PDF]
, 1985 Peter S. DiStefano +3 more
openalex +1 more source
Antibody-Mediated Inhibition of Ricin Toxin Retrograde Transport
mBio, 2014 Ricin is a member of the ubiquitous family of plant and bacterial AB toxins that gain entry into the cytosol of host cells through receptor-mediated endocytosis and retrograde traffic through the trans-Golgi network (TGN) and endoplasmic reticulum (ER ...
Anastasiya Yermakova +4 more
doaj +1 more source