Results 41 to 50 of about 7,683 (166)

A drug interaction study investigating the effect of Rifabutin on the pharmacokinetics of Maraviroc in healthy subjects - Fig 4

, 2019
Steady-state geometric mean (log-scale) Rifabutin (A) and 25-O-desacetyl Rifabutin (B) concentration-time profile for participants receiving Maraviroc and Rifabutin.
E. Sabri (7542692), C. la Porte (7542683), G. Zhang (808141), M. Ghannad (7542677), R. Mallick (5874875), M. Dennehy (7542680), S. Kanji (3407216), D. W. Cameron (7542695), I. Seguin (7542686), D. Tardiff (7542689)   +9 more
core   +1 more source

The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain [PDF]

, 2014
BCL6 is a transcriptional repressor that is over-expressed due to chromosomal translocations, or other abnormalities, in ~40% of diffuse large B-cell lymphoma.
Simon D. Wagner (530388), Jamieson, Andrew G, Louise Fairall, Simon D Wagner, Wagner, Simon D, Jamieson Andrew G., Schwabe John W. R., Ko Ferrigno Paul, John W. R. Schwabe (7604093), Paul Ko Ferrigno (41085), Goult, Benjamin T., Benjamin T Goult, Ford, Robert, Sian E Evans, Andrew G Jamieson, Fairall, Louise, Andrew G. Jamieson (530386), Wagner, Simon D., Benjamin T. Goult (173495), Sian E. Evans (7622282), Ko Ferrigno, Paul, Evans, Sian E, Robert Ford (89276), Ford Robert, Schwabe, John W R, Goult Benjamin T., P. Ko Ferrigno (7674905), Evans Sian E., Fairall Louise, Schwabe, John W.R., Simon D. Wagner (7633943), John W R Schwabe, Evans, Sian E., Goult, Benjamin T, Robert Ford, Jamieson, Andrew G., Louise Fairall (530385), John W. R. Schwabe (530387), Wagner Simon D., Sian E. Evans (530384), Paul Ko Ferrigno, R. Ford (7674908), Ferrigno, Paul Ko, Schwabe, John WR   +43 more
core   +1 more source

Expert Recommendations for Use of Combined Oral Contraceptives in Preadolescent and Young Adolescent Patients With Acne Vulgaris

Pediatric Dermatology, EarlyView.
ABSTRACT Acne vulgaris commonly presents in early adolescence with the onset of adrenarche. Treatments for acne in this age group typically mirror those in older adolescents. However, while combined oral contraceptives are an effective hormonal treatment for acne vulgaris in young women, the safety of using a systemic hormonal therapy in younger ...
Andrea L. Zaenglein, Natalie Allen, Sasigarn Bowden, Hannah R. Chang, Kristina Derrick, Alison Edelman, Dawn Eichenfield, Lawrence Eichenfield, Sarah Gold, Emmy Graber, Julie Harper, Sarah Horvath, Patricia Huguelet, Karin J. Kartawira, Leah Lalor, Irene Lara‐Corrales, Megha M. Tollefson, Tierney E. Wallace, Jonette Keri   +18 more
wiley   +1 more source

Rifabutin-induced cystoid macular oedema [PDF]

, 2017
Rifabutin is a semi-synthetic antimycobacterial agent mainly used in the treatment of Mycobacterium avium-complex (MAC) in AIDS patients. Rifabutin-induced anterior uveitis has been reported previously.
Vaudaux, J. D., Guex-Crosier, Y.
core  

Global access of rifabutin for the treatment of tuberculosis - why should we prioritize this? [PDF]

, 2019
Introduction: Rifabutin, a rifamycin of equivalent potency to rifampicin, has several advantages in its pharmacokinetic and toxicity profile, particularly in HIV co-infected patients on combined antiretroviral therapy (cART).
Hill, Andrew M, Barber, Melissa, Andrew M Hill, Neesha Rockwood, Melissa Barber, Pozniak, Anton L, Cerrone, Maddalena, Anton L Pozniak, Rockwood, Neesha, Maddalena Cerrone   +9 more
core   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

In Vitro Activity of Rifabutin and Rifampin against Antibiotic-Resistant Acinetobacter baumannii, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae

mSphere, 2021
We recently reported that the antimicrobial activity of rifabutin against Acinetobacter baumannii is best modeled by the use of RPMI for in vitro susceptibility testing.
Bosul Lee, Jun Yan, Amber Ulhaq, Sarah Miller, Wonjae Seo, Peggy Lu, Rosemary She, Brad Spellberg, Brian Luna   +8 more
doaj   +1 more source

Crystal structure of tyrosine‐tRNA synthetase from Helicobacter pylori G27

Acta Crystallographica Section F, Volume 82, Issue 11, Page 369-375, November 2026.
The production, crystallization and 2.2 Å resolution structure of H. pylori tyrosine‐tRNA synthetase are reported.Helicobacter pylori, a major cause of gastric ulcers and cancers, infects nearly half of the world's population. The crystal structure of a potential H.
David Igbalajobi, Jason E. Taylor, Raymond Gao, Jesuferanmi Ayanlade, Rachael Zigweid, Sandhya Subramanian, Hannah Udell, Thomas E. Edwards, Jan Abendroth, Donald Lorimer, Peter J. Myler, Bart Staker, Edmund Moses Ndip, Oluwatoyin A. Asojo   +13 more
wiley   +1 more source

Pharmacokinetic Evaluation of Rifabutin in Combination with Lopinavir-Ritonavir in Patients with HIV Infection and Active Tuberculosis

, 2020
Background. Human immunodeficiency virus (HIV)-associated tuberculosis is difficult to treat, given the propensity for drug interactions between the rifamycins and the antiretroviral drugs.
• Rifabutin With Lopinavir-Ritonavir, Cid   +1 more
core  

Pharmacokinetic Interaction Study of Ritonavir-Boosted Saquinavir in Combination with Rifabutin in Healthy Subjects

, 2011
The effect of multiple doses of rifabutin (150 mg) on the pharmacokinetics of saquinavir-ritonavir (1,000 mg of saquinavir and 100 mg of ritonavir [1,000/100 mg]) twice daily (BID) was assessed in 25 healthy subjects. Rifabutin reduced the area under the
Miklos Salgo, Scott Fettner, Xiaoping Zhang, Elke Zwanziger, Lucy Rowell   +4 more
core   +1 more source