Results 51 to 60 of about 5,853 (155)

Quality by Design‐Based Development of a Robust LC Method for Simultaneous Estimation of Process‐ and Degradation‐Related Impurities in Rifapentine Drug Product for the Treatment of Active and Latent Tuberculosis

Biomedical Chromatography, Volume 40, Issue 5, May 2026.
ABSTRACT A precise, robust, and stability‐indicating liquid chromatographic (LC) method coupled with a photodiode array (PDA) detector was developed and validated for the quantitative estimation of rifapentine, an essential therapeutic agent for both active and latent tuberculosis (TB).
Siva Prasad Korikana, Sreenivasa Rao Battula, Naresh Konduru, Aravind Kurnool, Divya Kumar Vemuri, Venkata Lakshamana Sagar Dantinapalli   +5 more
wiley   +1 more source

Rifabutin-Induced SIADH and Leucopenia in a Renal Transplant Recipient with Genitourinary Tract Tuberculosis: A Case Report and Review of the Literature

Case Reports in Nephrology and Dialysis, 2022
Tuberculosis (TB) infection of the genitourinary tract (GU TB) is rare in renal transplant recipients, with only a few published case series. GU TB is difficult to diagnose with or without immunosuppression but must always be suspected in any patient ...
Maha Mohamed, Muhammad Waseem Athar, Yaasir Mamoojee, Alison Brown, Frances Dowen, Jim Macfarlane   +5 more
doaj   +1 more source

Experimental study of the pharmacokinetics of rifabutin in liposomal form

Фармакокинетика и Фармакодинамика, 2013
On mongrel male rats studied pharmacokinetics of rifabutin in liposomal form, the relative bioavailability and tissue distribution after intratracheal administration, evaluated pharmacokinetic linearity.
M. V. Carlin, V. M. Cosman, O. N. Pozharitskaya, A. N. Shikov, M. N. Makarova, V. G. Makarov, V. Y. Balabanyan   +6 more
doaj  

Segmental retinal arteritis in a case of presumed bilateral rifabutin-associated hypopyon uveitis

American Journal of Ophthalmology Case Reports
Purpose: To describe the presentation and clinical course of bilateral hypopyon uveitis and subsequently diagnosed segmental retinal arteritis in an immunocompromised patient treated with intravitreal and systemic antibiotics while on rifabutin therapy ...
Shefali Sood, Jeanette Du, Allison Chen, Andy Medina, Brian K. Do   +4 more
doaj   +1 more source

High Eradication Rate of a Potassium‐Competitive Acid Blocker‐Based Minocycline, Furazolidone, and Bismuth Regimen for Refractory Helicobacter pylori Infection: A Real‐World Study

Helicobacter, Volume 31, Issue 3, May/June 2026.
ABSTRACT Background Management of refractory Helicobacter pylori (H. pylori) infection remains challenging due to increasing antibiotic resistance and limited effective rescue options. Minocycline and furazolidone retain low resistance rates, while potassium‐competitive acid blockers (P‐CABs) provide potent and sustained acid suppression.
Ji‐Yan Li, Ying‐Ying Han, Dong‐Yan Li, Jing‐Mei Liu, Zhen‐Zhen Zhou, Ya‐Ni Zhou, Lin Tuo, Xiao‐Jiao Yao, Mei Liu, Ge Wang, Pei‐Yuan Li   +10 more
wiley   +1 more source

Population Pharmacokinetic Modeling Practice of Time‐Varying Clearance: Insights from a First‐in‐Human Study Case

The Journal of Clinical Pharmacology, Volume 66, Issue 3, March 2026.
Abstract Accurate characterization of time‐varying clearance (CL) is critical during early drug development, as it informs clinical study design and dosing strategies for future trials. However, detecting and modeling time‐varying clearance is challenging due to limited data availability in early clinical development.
Yongjun Hu, Lan Gao, Ronald Kong
wiley   +1 more source

Rifabutin Resistance Associated with Double Mutations in rpoB Gene in Mycobacterium tuberculosis Isolates

Frontiers in Microbiology, 2017
The objective of this study was to investigate the cross-resistance between rifampin (RIF) and rifabutin (RFB) among clinical Mycobacterium tuberculosis (MTB) isolates, and the correlations between specific rpoB mutations and the minimum inhibitory ...
Wei Jing, Yu Pang, Zhaojing Zong, Jing Wang, Ru Guo, Fengmin Huo, Guanglu Jiang, Yifeng Ma, Hairong Huang, Naihui Chu   +9 more
doaj   +1 more source

Review Article: Classic Bismuth Quadruple Therapy for Helicobacter pylori Infection—Questions Focused on Clinical Practice

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 5, Page 616-636, March 2026.
BQT remains the most effective, safe, and practical regimen for H. pylori eradication, ensuring high cure rates across diverse resistance patterns and clinical settings. ABSTRACT Background Classic bismuth quadruple therapy (BQT)—the combination of a proton pump inhibitor, bismuth, tetracycline, and metronidazole—is a standard regimen for treating ...
Javier P. Gisbert, Pablo Parra, Olga P. Nyssen   +2 more
wiley   +1 more source

Сlinical and molecular aspects of helicobacter pylori resistance to antimicrobial drugs

Медицинский совет, 2013
The literature review tells about current views on the clinical and molecular aspects of antibiotic resistance of Helicobacter pylori (H. pylori). Today, the growing number of H.
Y. A. Kucheryaviy, D. M. Andreyev, E. V. Barkalova   +2 more
doaj   +1 more source

Helicobacter pylori Eradication Primary Care First‐Line Prescriptions: Data From 200,000 Patients in a Real‐World Cohort

Helicobacter, Volume 31, Issue 2, March/April 2026.
ABSTRACT Background Helicobacter pylori is a common infection primarily managed in primary care. Assessing real‐world practices and guideline adherence is crucial for treatment optimisation. The study aims to assess current H. pylori management strategies using data from BIFAP, a Spanish primary care database.
Encarnación Fernández‐Antón, Olga P. Nyssen, Gabriela Alonso‐Martínez, Pablo Parra, Miguel Gil, Javier P. Gisbert, Francisco J. de Abajo   +6 more
wiley   +1 more source