Results 51 to 60 of about 7,683 (166)

Low-Dose Rifabutin Increases Cytotoxicity in Antimitotic-Drug-Treated Resistant Cancer Cells by Exhibiting Strong P-gp-Inhibitory Activity

, 2022
The cytotoxicity of various antibiotics at low doses in drug-resistant cancer cells was evaluated. Low doses of rifabutin were found to markedly increase the cytotoxicity of various antimitotic drugs, such as vincristine (VIC), to P-glycoprotein (P-gp ...
Yoon, Sungpil, Kim, Hyung Sik, Oh, Yunmoon, Sungpil Yoon, Yunmoon Oh, Hyung Sik Kim, Lee, Ji Sun, Ji Sun Lee   +7 more
core   +1 more source

Synthesis, Characterization, and In Vitro Evaluation of New Amino‐Alcohol Quinolines as Promising Antimycobacterial Agents

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Nontuberculous mycobacteria (NTM) mainly Mycobacterium avium complex (MAC), are emerging pathogens responsible for pulmonary infections. The efficacy of the standard treatment is therefore compromised by the emergence of intrinsic and acquired resistance in MAC.
Elise Si Ahmed Charrier, François Peltier, Jean‐François Raimbert, Marie Perret, Claire Andréjak, Alexandra Dassonville‐Klimpt, Pascal Sonnet   +6 more
wiley   +1 more source

Superior Efficacy of Bismuth-Containing Rifabutin Quadruple Therapy over Rifabutin Triple Therapy as Salvage Treatment

Gut and Liver
Background/Aims : Helicobacter pylori is a pathogen that causes chronic gastritis and peptic ulcer diseases and is a carcinogen responsible for the development of malignancies, including gastric cancer. In the current era of high antimicrobial resistance,
Hannah Lee, Jun-Won Chung, Kyoung Oh Kim, Kwang An Kwon, Jung Ho Kim   +4 more
doaj   +1 more source

The potential use of rifabutin for treatment of patients diagnosed with rifampicin-resistant tuberculosis.

, 2018
<p><b>Background: </b>Use of the Xpert MTB/RIF assay has increased the number of people diagnosed with rifampicin-resistant tuberculosis (RR-TB), especially in South Africa where Xpert is now the initial diagnostic for individuals with ...
Michael G Whitfield, G. Groenen, Wendy Stevens, Elise De Vos, Annelies Van Rie, Scott, Lesley, W. Stevens, Van Rie, Annelies, L. Scott, Streicher, Elizabeth M., Robin M Warren, Elizabeth M Streicher, Guido Groenen, Warren, Robin M., Lesley Scott, Stevens, Wendy, De Vos, Elise, E.M. Streicher, Mathys, Vanessa, F.A. Sirgel, Groenen, Guido, Whitfield, Michael G., V. Mathys, E. De Vos, A. Van Rie, Sirgel, Frederick A., M.G. Whitfield, Vanessa Mathys, Frederick A Sirgel, R.M. Warren   +29 more
core   +1 more source

Multi‐omics–driven precision medicine

iMeta, Volume 5, Issue 5, October 2026.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

The Proportion of Rifabutin-susceptible Strains among Rifampicin-resistant Isolates and Its Specific rpoB Mutations [PDF]

, 2017
Background : Rifabutin (ansamycin) is a spiro-piperidyl rifamycin, which is highly active against Mycobacterium tuberculosis. It has been found that some clinical isolates of tubercle bacilli that are resistant to rifampicin are susceptible to rifabutin,
김성규
core  

Helicobacter pylori Resistance to Rifabutin in the Last 7 Years

, 2011
A low rate of resistance (0.24%) to rifabutin was noted in Helicobacter pylori strains isolated from 414 Japanese patients.
Juntaro Matsuzaki, Hiroe Muraoka, Hitoshi Tsugawa, Toshifumi Hibi, Toshihiro Nishizawa, Kenro Hirata, Hidekazu Suzuki   +6 more
core   +1 more source

Antimicrobial Resistance‐Stratified Efficacy of Vonoprazan, Clarithromycin, and Metronidazole Therapy for Helicobacter pylori Eradication in Penicillin‐Allergic Patients: A Single‐Arm Prospective Interventional Study

JGH Open, Volume 10, Issue 10, October 2026.
ABSTRACT Background Choosing an effective Helicobacter pylori eradication regimen for patients with penicillin allergy remains a clinical challenge. Although vonoprazan‐based regimens yield excellent outcomes in standard populations, we still lack sufficient evidence regarding penicillin‐allergic patients.
Soichiro Sue, Ryosuke Ikeda, Aya Ikeda, Hiroki Sato, Yoshihiro Goda, Hiroaki Kaneko, Kuniyasu Irie, Shin Maeda   +7 more
wiley   +1 more source

A rare case of pulmonary mycobacteriosis caused by rifabutin resistant Mycobacterium celatum and review of the literature

Respiratory Medicine Case Reports, 2019
The present case demonstrates an atypical pulmonary mycobacteriosis that mimicked classical symptoms and radiology findings for tuberculosis. While T-SPOT Test and PCR analyses proved negative for tuberculosis, microscopic sputum evaluation showed acid ...
Marcela Doktorova Demmin, Adrian Gillissen   +1 more
doaj   +1 more source

CRISPR Interference-Based Inhibition of MAB_0055c Expression Alters Drug Sensitivity in Mycobacterium abscessus

Microbiology Spectrum, 2023
There is an unmet medical need for effective treatments against Mycobacterium abscessus infections. Although advanced molecular genetic tools to validate drug targets and resistance of M. abscessus exist, the practical design and construction of plasmids
Thanh Quang Nguyen, Bo Eun Heo, Yujin Park, Seunghyeon Jeon, Arunima Choudhary, Cheol Moon, Jichan Jang   +6 more
doaj   +1 more source