Results 151 to 160 of about 113,465 (266)

Polyphenol oxidase depletion in Nicotiana benthamiana enhances recombinant protein purification and preserves native protein integrity

New Phytologist, Volume 251, Issue 3, Page 1283-1293, August 2026.
Polyphenol oxidases (PPOs) depletion preserves endogenous proteins at their predicted molecular weights and enhances detectable enzymatic activities. (a) Less RbcL crosslinking in ppo mutant of Nicotiana benthamiana. Leaf extracts were incubated for 1 h, separated on protein gels, stained with Coomassie or analyzed by Western blot with the anti‐RbcL ...
Kaijie Zheng, Farnusch Kaschani, Emma C. Watts, Markus Kaiser, Renier A. L. van der Hoorn   +4 more
wiley   +1 more source

Cross‐stage single‐cell and spatial metabolome analyses reveal periderm specialization and tanshinone biosynthesis in Salvia miltiorrhiza roots

New Phytologist, Volume 251, Issue 3, Page 1267-1282, August 2026.
Biosynthesis and accumulation of tanshinones in the periderm of Salvia miltiorrhiza during secondary root growth. Summary Perennial herbs develop long‐lived roots that undergo repeated cycles of secondary growth, during which the periderm functions as a protective barrier and a major site of specialized metabolite accumulation.
Licheng Liu, Lianchong Gao, Zhi‐Ying Wang, Yan Liu, Huifeng Ju, Huana Lin, Zheng Shi, Wen‐Juan Cai, Xue Li, Yan‐Bo Huang, Yu Kong, Jing‐Jing Xu, Hong‐Peng Chen, Xin Fang, Juan Guo, Yong‐Hong Hu, Ke Chen, Xiao‐Ya Chen, Jie Hao, Lei Yang   +19 more
wiley   +1 more source

Early penile prosthesis infections in the contemporary antimicrobial era: Incidence and predictive factors from a regional cohort

BJUI Compass, Volume 7, Issue 7, July 2026.
Abstract Objectives To evaluate the incidence and predictive factors of early penile prosthesis (PP) infection within a contemporary regional cohort in the North of England. Patients and methods A retrospective review of all PP implantations was conducted at a tertiary urology and andrology centre between 2018 and 2025, with variables including age ...
Imaad Amanulla, Mohamed Mubarak, John Hayes, Michael Rafeh, Ethan Clifford, Jon Barclay, Trevor Dorkin, Anthony Emmanuel   +7 more
wiley   +1 more source

Effect of carbamazepine on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader, in healthy adults

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2183-2192, July 2026.
Aim To evaluate the effects of carbamazepine, a strong cytochrome P450 (CYP)3A4 inducer, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader. Methods This was a phase 1, open‐label, fixed‐sequence, two‐period study in healthy adult participants.
Hechuan Wang, Jennifer A. Winton, Kyle T. Matschke, Alexandre Stouffs, Kimberly C. Lee, Yuanyuan Zhang, Wenlian Qiao, Weiwei Tan   +7 more
wiley   +1 more source

Is a Clinical Trial With a Non‐Bioequivalent Batch Necessary? The Critical Role of Intrasubject Variability in Olaparib Formulation Bridging by PBPK

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 203-213, July 2026.
Although physiologically based pharmacokinetic (PBPK) modeling is increasingly being used to support oral drug formulation bridging, the acceptance by regulatory agencies is low. One of the primary concerns is the absence of clinical pharmacokinetic (PK) data from a non‐bioequivalent (non‐BE) batch during model validation.
Jin Dong, Andrea Moir, Xavier Pepin, Elizabeth Lowe, Sandy Hopkins, Weifeng Tang, Diansong Zhou   +6 more
wiley   +1 more source

The relevancy of controlled nanocrystallization on rifampicin characteristics and cytotoxicity

, 2016
Salma M Mohyeldin, Mohammed M Mehanna, Nazik A Elgindy Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt Purpose: This article investigated the influence of novel rifampicin nanosuspension (RIF NS) for ...
Mohyeldin SM, Elgindy NA, Mehanna MM
core  

Interplay Between Infectious Diseases and the Endocrine System: An Overview and Clinical Insights

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 4, July 2026.
Infectious diseases can disrupt endocrine homeostasis through direct cytopathic injury, autoimmune dysregulation, or pathogen‐derived hormone‐like effects. Viruses and bacteria are the most frequent agents, whereas fungi and parasites contribute less commonly, even remaining clinically relevant, especially in the immunocompromised population.
Francesco Capoccia, Valentina D'Onghia, Valentina Semeraro, Esposito Susanna, Maria Elisabeth Street   +4 more
wiley   +1 more source

Complexed rifampicin with iron mitigates doxorubicin-induced nephrotoxicity. [PDF]

BMC Pharmacol Toxicol
Basal OA, Saad EA, El Sadda RR.
europepmc   +1 more source

Outcomes and safety of concomitant nevirapine and rifampicin treatment under programme conditions in Malawi.

, 2010
SETTING: Thyolo District Hospital, rural Malawi. OBJECTIVES: To report on 1) clinical, immunological and virological outcomes and 2) safety among human immunodeficiency virus (HIV) infected patients with tuberculosis (TB) who received concurrent ...
Zachariah, R, Misinde, D, Tayler-Smith, K, Manzi, M, Harries, AD, Foncha, C, Moses, M, Bauerfeind, A, Harries, A D, Mwagomba, B, Kwanjana, J   +10 more
core  

Survival of a potential bacterial biocontrol agent in the soil and its impact on microbial communities

Pest Management Science, Volume 82, Issue 7, Page 6984-6998, July 2026.
In soil microcosms, the candidate Bacillus persisted ≥6 months and caused modest community shifts whose transience and magnitude were soil dependent. Abstract BACKGROUND Sclerotinia sclerotiorum is a major crop pathogen commonly managed using fungicides.
Amélie Polrot, Jérémie Béguet, Marie‐Christine Breuil, Marion Devers‐Lamrani, Fabrice Martin‐Laurent, Nadine Rouard, Aymé Spor   +6 more
wiley   +1 more source