Results 11 to 20 of about 113,465 (266)

The bacterial phosphotransferase system-mediated rifampicin phosphorylation: ancestral links to rifampicin-inactivating enzyme [PDF]

Frontiers in Microbiology
IntroductionThe bacterial phosphotransferase system (PTS) transports and phosphorylates sugars. Some PTS proteins share structural motifs with rifampicin phosphotransferases (RPHs), which inactivate rifampicin by phosphorylation.
Šárka Bobková, Michaela Plechatá, Tomáš Kovaľ, Hana Šanderová, Simona Blažková, Rüveyda Akçin, Zdeněk Kameník, Jan Dohnálek, Libor Krásný, Jana Wiedermannová   +9 more
doaj   +2 more sources

High-dose rifampicin kills persisters, shortens treatment duration, and reduces relapse rate in vitro and in vivo

Frontiers in Microbiology, 2015
Although high-dose rifampicin holds promise for improving tuberculosis control by potentially shortening treatment duration, these effects attributed to eradication of persistent bacteria are unclear. The presence of persistent M.
Yanmin Hu, Anthony Coates, Hu Yanmin
exaly   +3 more sources

Incidence of Rifampicin Resistance in Periprosthetic Joint Infection: A Single-Centre Cohort Study on 238 Patients

Antibiotics, 2023
Background. Rifampicin is a pillar in the treatment of periprosthetic joint infection (PJI). However, rifampicin resistance is an increasing threat to PJI treatment.
Stergios Lazarinis, Nils P. Hailer, Josef D. Järhult, Anders Brüggemann   +3 more
doaj   +1 more source

Improved outcome with early rifampicin combination treatment in methicillin-sensitive Staphylococcus aureus bacteraemia with a deep infection focus - a retrospective cohort study. [PDF]

PLoS ONE, 2015
INTRODUCTION:Rifampicin has been used as adjunctive therapy in Staphylococcus aureus bacteraemia (SAB) with a deep infection focus. However, data for prognostic impact of rifampicin therapy is unestablished including the optimal initiation time point. We
Erik Forsblom, Eeva Ruotsalainen, Asko Järvinen   +2 more
doaj   +1 more source

Rifampicin-Induced Hepatic Lipid Accumulation: Association with Up-Regulation of Peroxisome Proliferator-Activated Receptor γ in Mouse Liver. [PDF]

PLoS ONE, 2016
Previous study found that rifampicin caused intrahepatic cholestasis. This study investigated the effects of rifampicin on hepatic lipid metabolism. Mice were orally administered with rifampicin (200 mg/kg) daily for different periods.
Jia-Hui Huang, Cheng Zhang, Da-Gang Zhang, Lu Li, Xi Chen, De-Xiang Xu   +5 more
doaj   +1 more source

Combining LAMP and Au-Nanoprobe to detect INH-RIF resistance accurately in tuberculosis: an evidence-based review

Journal of Infection in Developing Countries, 2021
Approximately 1.41 million people die annually due to tuberculosis. One of the main problems in Tuberculosis eradication is the development of resistance to various antibiotics.
Muhammad Habiburrahman, Haekal Ariq, Raden Rara Diah Handayani   +2 more
doaj   +1 more source

Relationship between rifampicin resistance and RpoB substitutions of Rhodococcus equi strains isolated in France

Journal of Global Antimicrobial Resistance, 2020
Objectives: Study of the rifampicin resistance of Rhodococcus equi strains isolated from French horses over a 20-year period. Methods: Rifampicin susceptibility was tested by disk diffusion (DD) and broth macrodilution methods, and rpoB gene sequencing ...
Sandrine Petry, Corinne Sévin, Sofia Kozak, Nathalie Foucher, Claire Laugier, Maud Linster, Marie-France Breuil, Marie-Capucine Dupuis, Aymeric Hans, Fabien Duquesne, Jackie Tapprest   +10 more
doaj   +1 more source

GENE MUTATION PATTERNS OF RIFAMPICIN IN MULTIDRUG RESISTANT MYCOBACTERIUM TUBERCULOSIS COMPLEX STRAINS

İstanbul Tıp Fakültesi Dergisi, 2022
Objective: The aim of this study was to evaluate the GenoType®MTBDRplus test for detection of rifampicin (RIF) resistance in MDR Mycobacterium tuberculosis complex strains.
Esra Yıldırım Servi, Meltem Uzun
doaj   +1 more source

Rifampicin-Induced Thrombocytopenia: A Case Report and Short Review of the Literature [PDF]

, 2021
Thrombocytopenia may be associated with a variety of conditions and risks depending on its severity, ranging from mild epistaxis to life-threating bleeding. Many drugs or herbal remedies can cause thrombocytopenia by either inhibiting platelet production
Eleftheria Hatzimichael, Anastasia Serpanou, Eleni Kapsali, Konstantina Papathanasiou, Ioannis Papakonstantinou, Epameinondas Koumpis, Iliana Tassi   +6 more
core   +1 more source

Evaluation of Effectiveness of a New Kit of Reagents for Detection of Mutations Associated with Drug Resistance of Tuberculous Mycobacteria to Rifampicin and Isoniazid, by PCR according to Evidences of Clinical Trials

Туберкулез и болезни лёгких, 2023
The objective: to evalute effectiveness in clinical trials of the new kit of reagents of AmpliTest® MBT-Resist-I based on real-time PCR (RT-PCR) versus similar kits of reagent registered in Russia, to identify genetic markers of M.
Yu. L. Mikulovich, Yu. A. Savochkina, A. I. Zaytseva, A. E. Panova, A. S. Vinokurov, G. A. Shipulin   +5 more
doaj   +1 more source