Results 11 to 20 of about 98,103 (155)

Biodegradable and Bioactive Carriers Based on Poly(betulin disuccinate-co-sebacic Acid) for Rifampicin Delivery

Pharmaceutics, 2022
This paper describes the preparation and characterization of polymer-drug systems based on polymeric microspheres obtained from poly(betulin disuccinate-co-sebacic acid).
Daria Niewolik, Barbara Bednarczyk-Cwynar, Piotr Ruszkowski, Alicja Kazek-Kęsik, Grzegorz Dzido, Katarzyna Jaszcz   +5 more
doaj   +1 more source

The RNA Polymerase Inhibitor Corallopyronin A Has a Lower Frequency of Resistance Than Rifampicin in Staphylococcus aureus

Antibiotics, 2022
Corallopyronin A (CorA) is active against Gram-positive bacteria and targets the switch region of RNA polymerase. Because of the high frequency of mutation (FoM) leading to rifampicin resistance, we determined the CorA FoM in S.
Jan Balansky, Kenneth Pfarr, Christiane Szekat, Stefan Kehraus, Tilman Aden, Miriam Grosse, Rolf Jansen, Thomas Hesterkamp, Andrea Schiefer, Gabriele M. König, Marc Stadler, Achim Hoerauf, Gabriele Bierbaum   +12 more
doaj   +1 more source

Cell membrane components of Brucella melitensis play important roles in the resistance of low-level rifampicin.

PLoS Neglected Tropical Diseases, 2020
Brucella spp. are facultative intracellular pathogens that can persistently colonize host cells and cause the zoonosis- brucellosis. The WHO recommended a treatment for brucellosis that involves a combination of doxycycline, rifampicin, or streptomycin ...
Xiaowen Yang, Tonglei Wu, Wenxiao Liu, Guozhong Tian, Hongyan Zhao, Dongri Piao, Hai Jiang, Qingmin Wu   +7 more
doaj   +1 more source

High dose rifampicin kills persisters, shortens treatment duration and reduces relapse rate in vitro and in vivo

Frontiers in Microbiology, 2015
Although high-dose rifampicin holds promise for improving tuberculosis control by potentially shortening treatment duration, these effects attributed to eradication of persistent bacteria are unclear. The presence of persistent M.
Yanmin eHu, Alexander eLiu, Fatima eOrtega-Muro, Laura eAlameda-Martin, Denis eMitchison, Anthony eCoates   +5 more
doaj   +1 more source

Efficacy of Treatments for Cholestatic Pruritus: A Systemic Review and Meta-analysis

Acta Dermato-Venereologica, 2022
Cholestatic itch is a disabling symptom that may be secondary to liver or biliary diseases. Management of cholestatic pruritus is complex. A systematic review and meta-analysis on the efficacy of treatments for cholestatic pruritus were performed. PubMed
Charles Dervout, Nicholas Boulais, Thomas Barnetche, Jean-Baptiste Nousbaum, Emilie Brenaut, Laurent Misery   +5 more
doaj   +1 more source

Determining the Prevalence of Rifampicin Resistant Tuberculosis in A Tertiary Care Centre of North India by using Rapid Culture Method and Gene Xpert

Journal of Pure and Applied Microbiology, 2021
The objective of the present study is to find the prevalence of Mycobacterium tuberculosis from respiratory samples like sputum, BAL and pleural fluid, compare conventional LJ culture with rapid culture method i.e Mycobacterium growth indicator tube ...
Bipin Chandra Pokhriyal, Dimple Raina, Iva Chandola, Nidhi Negi, Hitendra Singh, Vijay Kataria   +5 more
doaj   +1 more source

High dose oral and intravenous rifampicin for improved survival from adult tuberculous meningitis: a phase II open-label randomised controlled trial (the RifT study) [version 1; referees: 2 approved]

Wellcome Open Research, 2018
Background: Tuberculous meningitis (TBM) has 44% (95%CI 35-52%) in-hospital mortality with standard therapy in Uganda. Rifampicin, the cornerstone of TB therapy, has 70% oral bioavailability and ~10-20% cerebrospinal fluid (CSF) penetration.
Fiona V. Cresswell, Kenneth Ssebambulidde, Daniel Grint, Lindsey te Brake, Abdul Musabire, Rachel R. Atherton, Lillian Tugume, Conrad Muzoora, Robert Lukande, Mohammed Lamorde, Rob Aarnoutse, David Meya, David R. Boulware, Alison M. Elliott   +13 more
doaj   +1 more source

A rare case of tuberculosis spine on antitubercular drug succumbing to pseudomembranous enterocolitis

Journal of Dr. NTR University of Health Sciences, 2021
Anti-tubercular therapy (ATT) drugs are the mainstay of management of tuberculosis worldwide. These medicines are used extensively across the globe in treating tubercular infections of any organ.
Simarjit S Rehsi, Nilanjan Roy, Vipin V Nair, Ajay K Baranwal, Prashant Sengupta, Pawan Sharma, Aman Kumar   +6 more
doaj   +1 more source

High-dose rifampicin in tuberculosis: Experiences from a Dutch tuberculosis centre.

PLoS ONE, 2019
BackgroundRecent evidence suggests that higher rifampicin doses may improve tuberculosis (TB) treatment outcome.MethodsIn this observational cohort study we evaluated all TB patients who were treated with high-dose rifampicin (> 10 mg/kg daily) in our ...
Charlotte Seijger, Wouter Hoefsloot, Inge Bergsma-de Guchteneire, Lindsey Te Brake, Jakko van Ingen, Saskia Kuipers, Reinout van Crevel, Rob Aarnoutse, Martin Boeree, Cecile Magis-Escurra   +9 more
doaj   +1 more source

EFFECTIVENESS OF REAL-TIME PCR FOR EXPRESS FIRST LINE DRUG SUSCEPTIBILITY TESTING OF TUBERCULOUS MYCOBACTERIA USING SPUTUM SAMPLES AND SURGICAL SPECIMENS OF LUNG TISSUE

Туберкулез и болезни лёгких, 2019
The objective of the study: to investigate the effectiveness of real-time PCR for express drug susceptibility testing in drug resistant pulmonary tuberculosis patients using sputum samples and specimens of lung tissue collected during surgery.Subjects ...
Yu. S. Alyapkina, A. A. Elov, L. K. Shipina, M. A. Vladimirskiy   +3 more
doaj   +1 more source