Results 41 to 50 of about 49,037 (222)
Rifampin-Fluconazole Interaction in Critically ILL Patients [PDF]
, 1995 Objective: To report the influence of rifampin coadministration on the pharmacokinetics of fluconazole in 2 critically ill patients. Case Summaries: The pharmacokinetics of fluconazole are reported in 5 patients in the intensive care unit (ICU), 2 of ...
Helen M Crowe +3 more
core +1 more source
New Microbes and New Infections, 2021 Multidrug-resistant (MDR) Mycobacterium tuberculosis strains, defined as resistant to at least isoniazid and rifampin, have emerged as a major worldwide health threat. Spontaneous point mutations in various genes of M.
B. Motavaf +5 more
doaj +1 more source
Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity
Advanced Science, EarlyView.Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai +7 more
wiley +1 more source
Characterization ofthe Rifampin ADP-ribosyl transferase Enzyme [PDF]
, 2006 The ansamycin antibiotics are unique antibacterial agents that inhibit bacterial DNAdependent RNA polymerase II. Clinical use of this class of antibiotics has primarily been focused on the treatment oftuberculosis using the semi-synthetic rifamycin ...
Baysarowich, Jennifer
core
Radical Scavenging of Poly(Methyl Methacrylate) Bone Cement by Rifampin and Clinically Relevant Properties of the Rifampin-Loaded Cement [PDF]
, 2019 Objectives: The objective of this study was to characterize the effect of rifampin incorporation into poly(methyl methacrylate) (pMMA) bone cement. While incompatibilities between the two materials have been previously noted, we sought to identify and ...
Menuey, E. M. +5 more
core +2 more sources
Clinical Pharmacology &Therapeutics, EarlyView.Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu +6 more
wiley +1 more source
Rifabutin MIC distribution stratified among conventional rifampin-susceptible and rifampin-resistant isolates. [PDF]
, 2015 Conventional rifampin susceptible by APM (agar proportion method) critical concentration (MIC≤1.0 μg/ml) and resistance (MIC >1.0 μg/ml). Rifabutin critical concentration = 0.5 μg/ml; susceptible (2.0 μg/ml).
Jean Gratz (412093) +9 more
core +1 more source
Frontiers in Microbiology, 2018 Multidrug-resistant tuberculosis (TB), defined as TB resistant to the two first-line drugs, isoniazid and rifampin, is a serious challenge to global TB eradication efforts.
Zhihong Xu +9 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Orforglipron is an orally administered, small‐molecule glucagon‐like peptide‐1 receptor agonist in clinical development for the treatment of type 2 diabetes and obesity. Orforglipron is a substrate of CYP3A4, organic anion transporting polypeptides (OATPs) 1B/1B3, and P‐glycoprotein (P‐gp); however, precipitants commonly used to define these mechanisms
Bridget L. Morse +7 more
wiley +1 more source
Randomized controlled trial of chlorhexidine gluconate for washing, intranasal mupirocin, and rifampin and doxycycline versus no treatment for the eradication of methicillin-resistant staphylococcus aureus colonization [PDF]
, 2007 Background. Eradication of methicillin-resistant Staphylococcus aureus (MRSA) carriage may reduce the risk of MRSA infection and prevent transmission of the organism to other patients. Methods.
Simor, A.E. +6 more
core +1 more source